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Drug Dev Ind Pharm ; 50(5): 432-445, 2024 May.
Artículo en Inglés | MEDLINE | ID: mdl-38526993

RESUMEN

OBJECTIVE: The purpose of this research was to determine any connections between the characteristics of oleogels made of beeswax and the impact of mango butter. METHODS: Oleogel was prepared through inverted tube methods, and optimized through oil binding capacity. Other evaluations like bright field and polarized microscopy, Fourier-transform infrared (FTIR) spectroscopy, crystallization kinetics, mechanical study, and X-ray diffractometry (XRD). The drug release kinetic studies and in vitro antibacterial studies were performed. RESULTS: FTIR study reveals that the gelation process does not significantly alter the chemical composition of the individual components. Prepared gel exhibiting fluid-like behavior or composed of brittle networks is particularly vulnerable to disruptions in their network design. The incorporation of mango butter increases the drug permeation. In-vitro microbial efficacy study was found to be excellent. CONCLUSION: The studies revealed that mango butter can be used to modify the physico-chemical properties of the oleogels.


Asunto(s)
Mangifera , Compuestos Orgánicos , Aceites de Plantas , Ceras , Ceras/química , Mangifera/química , Compuestos Orgánicos/química , Aceites de Plantas/química , Aceites de Plantas/farmacología , Semillas/química , Antibacterianos/química , Antibacterianos/farmacología , Antibacterianos/administración & dosificación , Administración Tópica , Espectroscopía Infrarroja por Transformada de Fourier/métodos , Liberación de Fármacos
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