RESUMEN
SUMMARY: The efficacy and safety of subcutaneous immunotherapy with modified, high-dose, major allergen house dust mite extract is widely supported by double-blind, placebo-controlled studies. However, little is known regarding patient-perceived efficacy and satisfaction. An observational, retrospective, multicentre study in patients treated with Acaroid® was conducted to assess the efficacy and degree of satisfaction of the patients after the first six months of treatment with it. All the clinical study procedures were performed according to the routine clinical practice. This study demonstrates that Acaroid® is effective and well tolerated. The patients' condition demonstrated a clear and marked improvement in the first 6 months after treatment initiation. Patients treated with Acaroid® were very satisfied, with a correlation to improvement in patient-perceived symptoms and the administration of treatment by a healthcare professional.
Asunto(s)
Satisfacción del Paciente , Pyroglyphidae/inmunología , Adolescente , Adulto , Anciano , Animales , Niño , Preescolar , Desensibilización Inmunológica/métodos , Humanos , Persona de Mediana Edad , Estudios Retrospectivos , Encuestas y CuestionariosAsunto(s)
Acetaminofén/efectos adversos , Analgésicos no Narcóticos/efectos adversos , Erupciones por Medicamentos/etiología , Hipersensibilidad a las Drogas/inmunología , Fenilefrina/efectos adversos , Simpatomiméticos/efectos adversos , Acetaminofén/administración & dosificación , Acetaminofén/química , Adulto , Analgésicos no Narcóticos/administración & dosificación , Pruebas de Provocación Bronquial , Resfriado Común/tratamiento farmacológico , Resfriado Común/inmunología , Resfriado Común/fisiopatología , Reacciones Cruzadas , Hipersensibilidad a las Drogas/fisiopatología , Femenino , Cefalea/prevención & control , Humanos , Pruebas del Parche , Fenilefrina/administración & dosificación , Fenilefrina/química , Simpatomiméticos/administración & dosificaciónRESUMEN
We reported on the case of a patient who developed a cutaneous eruption in a photoexposed area 1 week after a continous topical treatment with dexketoprofen (Enangel). Photopatch tests were positive for dexketoprofen, ketoprofen and piketoprofen and patch test was positive for piketoprofen. Control photopatch testing with dexketoprofen in 15 healthy volunteers was negative. Dexketoprofen, ketoprofen and piketoprofen are non-steroidal anti-inflamatory drugs (arylpropionic acid derivatives) often used as topical anti-inflammatory agents. It appears that the benzophenone moiety of their chemical structure is the cause of their photosensitivity and cross-photoreaction.
Asunto(s)
Dermatitis Alérgica por Contacto/etiología , Dermatitis Fotoalérgica/etiología , Cetoprofeno/análogos & derivados , Cetoprofeno/efectos adversos , Administración Tópica , Anciano , Dermatitis Alérgica por Contacto/fisiopatología , Dermatitis Fotoalérgica/diagnóstico , Femenino , Estudios de Seguimiento , Humanos , Cetoprofeno/uso terapéutico , Pruebas del Parche , Medición de Riesgo , Sensibilidad y EspecificidadRESUMEN
BACKGROUND: The aim of this study was to determine the use of specific immunotherapy (SIT) in public and private hospitals in Catalonia (Spain) in the management of respiratory allergic diseases and opinions about this treatment through a questionnaire. SIT dosage schedules and the creation of immunotherapy units were also investigated. METHODS AND RESULTS: A questionnaire containing eight items was sent by post and/or electronic mail to the heads of allergy units in 24 public and private hospitals in Catalonia.A total of 18 hospitals responded. The most commonly used route of administration was subcutaneous (89.4 %, SD 9.05) and the most widely used dosage schedule was the classical schedule (77.2 %, SD 24.9). Most of the hospitals (83.3 %) believed that immunotherapy units were an advantage but only 44 % of them believed that their creation was feasible. CONCLUSIONS: The results of this survey identify the application of SIT in Catalonia and reveal certain features of this treatment that remain to be established such as the optimal dosage schedule and the precautions that should be followed when administering SIT.
Asunto(s)
Desensibilización Inmunológica/estadística & datos numéricos , Citas y Horarios , Recolección de Datos , Unidades Hospitalarias/estadística & datos numéricos , Hospitales Privados/estadística & datos numéricos , Hospitales Públicos/estadística & datos numéricos , Humanos , Pautas de la Práctica en Medicina , España , Encuestas y CuestionariosRESUMEN
A patient suffered a myocardial injury as a manifestation of anaphylactic reaction to amoxicillin-clavulanic acid administration. A cardiologic study (ergometry and catheterization) showed no obstructive coronary disease and prick test to amoxicillin was positive. Anaphylaxis may cause myocardial injury and the mechanism is likely to be vasospasm induced by mast cells and basophil mediators.