1.
Org Lett
; 24(47): 8609-8614, 2022 Dec 02.
Artículo
en Inglés
| MEDLINE
| ID: mdl-36403144
RESUMEN
A halotrimethylsilane (TMSX) accelerated cascade halophosphorylation and cycloisomerization of γ-hydroxyl ynones with diphenylphosphine oxides is presented. This methodology allows the one-step synthesis of practical polysubstituted halophosphorylated dihydrofuran derivatives. It is noteworthy that halotrimethylsilane functions as a halogenation reagent as well as a promoter to initiate this transformation. In addition, the reaction system can also be scaled up to gram quantities, and the produced halogenated compounds can undergo further derivatizations by Pd-catalyzed coupling reactions.