IL-17 Control of Cutaneous Immune Homeostasis.

IL-17 is widely recognized for its roles in host defense and inflammatory disorders. However, it has become clear that IL-17 is also an essential regulator of barrier tissue physiology. Steady-state microbe sensing at the skin surface induces low-level IL-17 expression that enhances epithelial integrity and resists pathogens without causing overt inflammation. Recent reports describe novel protective roles for IL-17 in wound healing and counteracting physiologic stress; however, chronic amplification of these beneficial responses contributes to skin pathologies as diverse as fibrosis, cancer, and autoinflammation. In this paper, we discuss the context-specific roles of IL-17 in skin health and disease and therapeutic opportunities.

Maximizing tendency predicts university adjustment and academic performance.

Introduction: Decision-making characteristics that contribute to university adjustment and academic performance have been important topics in the research on success in higher education. This study proposes a new perspective that maximizing tendency, as a decision-making style, influences adaptive outcomes in college life. Materials and methods: Two studies were performed to investigate the positive effects of maximizing tendency on university adjustment and academic performance. In Study 1, we engaged in multistage data collection and surveyed 552 students in four universities. In over a span of 4 years, Study 2 was designed as a time-lagged survey with 309 students. Results: The results revealed that maximizers among students have better university adjustment after their first year at school and achieve higher GPAs when they finished their bachelor's degree. Furthermore, eudaimonic well-being mediated the relationship between maximizing tendency and university adjustment (Study 1), whereas university adjustment mediated the relationship between maximizing tendency and college student's academic performance (Study 2). Conclusion: These consistent results imply that maximizing tendency as a predictor of university adjustment and academic performance, showing its long-term positive impacts on adaptability and wellbeing.

Local IL-23 is required for proliferation and retention of skin-resident memory TH17 cells.

The cytokine interleukin-23 (IL-23) is critical for development and maintenance of autoimmune inflammation in nonlymphoid tissues; however, the mechanism through which IL-23 supports tissue-specific immunity remains unclear. In mice, we found that circulating memory T cells were dispensable for anamnestic protection from Candida albicans skin infection, and tissue-resident memory (TRM) cell-mediated protection from C. albicans reinfection required IL-23. Administration of anti-IL-23 receptor antibody to mice after resolution of primary C. albicans infection resulted in loss of CD69+ CD103+ tissue-resident memory T helper 17 (TRM17) cells from skin, and clinical anti-IL-23 therapy depleted TRM17 cells from skin of patients with psoriasis. IL-23 receptor blockade impaired TRM17 cell proliferation but did not affect apoptosis susceptibility or tissue egress. IL-23 produced by CD301b+ myeloid cells was required for TRM17 maintenance in skin after C. albicans infection, and CD301b+ cells were necessary for TRM17 expansion during the development of imiquimod dermatitis. This study demonstrates that locally produced IL-23 promotes in situ proliferation of cutaneous TRM17 cells to support their longevity and function and provides mechanistic insight into the durable efficacy of IL-23 blockade in the treatment of psoriasis.