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1.
Sensors (Basel) ; 24(13)2024 Jul 05.
Artículo en Inglés | MEDLINE | ID: mdl-39001147

RESUMEN

With the development of data mining technology, the analysis of event-related potential (ERP) data has evolved from statistical analysis of time-domain features to data-driven techniques based on supervised and unsupervised learning. However, there are still many challenges in understanding the relationship between ERP components and the representation of familiar and unfamiliar faces. To address this, this paper proposes a model based on Dynamic Multi-Scale Convolution for group recognition of familiar and unfamiliar faces. This approach uses generated weight masks for cross-subject familiar/unfamiliar face recognition using a multi-scale model. The model employs a variable-length filter generator to dynamically determine the optimal filter length for time-series samples, thereby capturing features at different time scales. Comparative experiments are conducted to evaluate the model's performance against SOTA models. The results demonstrate that our model achieves impressive outcomes, with a balanced accuracy rate of 93.20% and an F1 score of 88.54%, outperforming the methods used for comparison. The ERP data extracted from different time regions in the model can also provide data-driven technical support for research based on the representation of different ERP components.


Asunto(s)
Potenciales Evocados , Reconocimiento Facial , Humanos , Potenciales Evocados/fisiología , Reconocimiento Facial/fisiología , Electroencefalografía/métodos , Algoritmos , Cara/fisiología
2.
Res Sq ; 2024 May 24.
Artículo en Inglés | MEDLINE | ID: mdl-38826273

RESUMEN

We use a microfluidic ecology which generates non-uniform phage concentration gradients and micro-ecological niches to reveal the importance of time, spatial population structure and collective population dynamics in the de novo evolution of T4r bacteriophage resistant motile E. coli. An insensitive bacterial population against T4r phage occurs within 20 hours in small interconnected population niches created by a gradient of phage virions, driven by evolution in transient biofilm patches. Sequencing of the resistant bacteria reveals mutations at the receptor site of bacteriophage T4r as expected but also in genes associated with biofilm formation and surface adhesion, supporting the hypothesis that evolution within transient biofilms drives de novo phage resistance.

3.
Int J Infect Dis ; 144: 107055, 2024 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-38723889

RESUMEN

OBJECTIVES: To investigate cases of five Campylobacter jejuni outbreaks and describe laboratory characteristics of these infections. METHODS: Whole-genome sequencing and conventional methods were combined to thoroughly investigate the outbreaks, and data of contemporaneous sporadic cases was included for comparison. RESULTS: Seven sequence types (STs) of C. jejuni caused 83 cases, including ST9079 which recurred across 2 years. Trace-back investigation could not identify any food items of infection but detected identical campylobacters from food contacts. Phylogenetic analysis unveiled genetic closeness between outbreak strains and some concurrent sporadic strains, indicating local campylobacteriosis may not be wholly sporadic but rather a series of linked cases. Virulence genes disclosed species/case-specific signatures to differentiate outbreaks from truly non-outbreak strains. Resistance to fluoroquinolones and/or macrolides was prevalent (90.8%, 108/119), with a noteworthy portion exhibiting multidrug resistance (31.1%, 37/119). Five types of plasmids were harbored among outbreak isolates, of which one plasmid harboring anti-stress and resistant genes was rarely found in C. jejuni. CONCLUSIONS: This is the first reported sequential outbreak of C. jejuni in China. Our observations help to define the genomic landscape and antimicrobial resistance patterns of Campylobacter, emphasizing the need for a broader 'One Health' perspective to combat the threats posed by campylobacteriosis.


Asunto(s)
Antibacterianos , Infecciones por Campylobacter , Campylobacter jejuni , Brotes de Enfermedades , Filogenia , Secuenciación Completa del Genoma , Campylobacter jejuni/genética , Campylobacter jejuni/efectos de los fármacos , Campylobacter jejuni/aislamiento & purificación , Campylobacter jejuni/clasificación , Humanos , China/epidemiología , Infecciones por Campylobacter/epidemiología , Infecciones por Campylobacter/microbiología , Adulto , Niño , Masculino , Femenino , Antibacterianos/farmacología , Adolescente , Persona de Mediana Edad , Farmacorresistencia Bacteriana Múltiple/genética , Adulto Joven , Preescolar , Pruebas de Sensibilidad Microbiana , Plásmidos/genética , Genoma Bacteriano
4.
Nat Food ; 5(5): 413-422, 2024 May.
Artículo en Inglés | MEDLINE | ID: mdl-38724686

RESUMEN

Salmonella enterica causes severe food-borne infections through contamination of the food supply chain. Its evolution has been associated with human activities, especially animal husbandry. Advances in intensive farming and global transportation have substantially reshaped the pig industry, but their impact on the evolution of associated zoonotic pathogens such as S. enterica remains unresolved. Here we investigated the population fluctuation, accumulation of antimicrobial resistance genes and international serovar Choleraesuis transmission of nine pig-enriched S. enterica populations comprising more than 9,000 genomes. Most changes were found to be attributable to the developments of the modern pig industry. All pig-enriched salmonellae experienced host transfers in pigs and/or population expansions over the past century, with pigs and pork having become the main sources of S. enterica transmissions to other hosts. Overall, our analysis revealed strong associations between the transmission of pig-enriched salmonellae and the global pork trade.


Asunto(s)
Salmonella enterica , Animales , Salmonella enterica/genética , Salmonella enterica/aislamiento & purificación , Porcinos , Europa (Continente)/epidemiología , Humanos , Salmonelosis Animal/epidemiología , Salmonelosis Animal/transmisión , Salmonelosis Animal/microbiología , Enfermedades de los Porcinos/microbiología , Enfermedades de los Porcinos/transmisión , Enfermedades de los Porcinos/epidemiología , Crianza de Animales Domésticos/métodos , Carne de Cerdo/microbiología , Américas/epidemiología , Microbiología de Alimentos
5.
Anal Chem ; 96(22): 9051-9059, 2024 06 04.
Artículo en Inglés | MEDLINE | ID: mdl-38776068

RESUMEN

Surface-enhanced Raman spectroscopy (SERS) tags have the advantages of unique fingerprint vibration spectrum, ultranarrow spectral line widths, and weak photobleaching effect, showing great potential for bioimaging. However, SERS imaging is still hindered for further application due to its weak spontaneous Raman scattering, biomolecular signal interference, and long acquisition times. Here, we develop a novel SERS tag of the core (Au)-shell (N-doped graphene) structure (Au@NGs) with ultrastrong and stable Raman signal (2180 cm-1) in the cellular Raman-silent region (1800-2800 cm-1) through base-promoted oxidative decarboxylation of amino acids. Exploring the factors (metal salts, amino acids, catalysts, temperature, etc.) to obtain Au@NGs with the strongest Raman signal commonly requires more than 100,000 separate experiments, while that using an orthogonal array testing strategy is reduced to 56. The existence of deep charge transfer between the Au surface and C≡N-graphene is proved by theoretical calculations, which means the ultrastrong signal of Au@NGs is the joint effect of electromagnetic and chemical enhancement. The Au@NGs have a detection sensitivity down to a single-nanoparticle level, and high-speed and high-resolution cellular imaging (4453 pixels) is obtained within 10 s by global Raman imaging. The combination of Au@NGs-based tags with ultrastrong intrinsic Raman imaging capability and global imaging technology holds great promise for high-speed Raman imaging.


Asunto(s)
Oro , Grafito , Espectrometría Raman , Espectrometría Raman/métodos , Oro/química , Grafito/química , Humanos , Nanopartículas del Metal/química , Propiedades de Superficie , Aminoácidos/análisis , Aminoácidos/química
6.
Chemphyschem ; 25(17): e202400416, 2024 Sep 02.
Artículo en Inglés | MEDLINE | ID: mdl-38752794

RESUMEN

Fossil fuels have clearly failed to meet people's growing energy needs due to their limited reserves, potential pollution of the environment, and high costs. The development of cleaner, renewable energy sources as well as secondary batteries for energy storage is imminent, in a modern society where energy demand is soaring. Sodium-ion batteries (SIBs) have become the focus of large-scale energy storage systems as a promising alternative to lithium-ion batteries. The development of SIBs relies on the construction of high performance electrode materials. The design of low cost and high performance anode materials is a key link in this regard. Copper-based anodes are characterized by high theoretical capacity, abundant reserves, low cost and environmental friendliness. A variety of copper-based anode materials, which include cobalt oxides, sulfides, selenides and phosphides, have been synthesized and evaluated in the scientific literature for sodium storage. In detail, the preparation methods, response mechanisms, strengths and weaknesses, the relationship between morphology structure and electrochemical performance are discussed, as well as highlighting strategies to improve the electrochemical performance of copper-based anode materials. Finally, we offer our perspective on the challenges and potential for the development of copper-based anodes as a means of developing practical and high performing SIBs.

7.
J Colloid Interface Sci ; 659: 422-431, 2024 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-38183808

RESUMEN

P2-type Na0.67Ni0.33Mn0.67O2 has attracted considerable attraction as a cathode material for sodium-ion batteries owing to its high operating voltage and theoretical specific capacity. However, when the charging voltage is higher than 4.2 V, the Na0.67Ni0.33Mn0.67O2 cathode undergoes a detrimental irreversible phase transition of P2-O2, leading to a drastic decrease in specific capacity. To address this challenge, we implemented a Cu-doping strategy (Na0.67Ni0.23Cu0.1Mn0.67O2) in this work to stabilize the structure of the transition metal layer. The stabilization strategy involved reinforcing the transition metal-oxygen (TMO) bonds, particularly the MnO bond and inhibiting interlayer slip during deep desodiation. As a result, the irreversible phase transition voltage is delayed, with the threshold voltage increasing from 4.2 to 4.4 V. Ex-situ X-ray diffraction measurements revealed that the Na0.67Ni0.23Cu0.1Mn0.67O2 cathode maintains the P2 phase within the voltage window of 2.5-4.3 V, whereas the P2-Na0.67Ni0.33Mn0.67O2 cathode transforms entirely into O2-type Na0.67Ni0.33Mn0.67O2 when the voltage exceeds 4.3 V. Furthermore, absolute P2-O2 phase transition of the Na0.67Ni0.23Cu0.1Mn0.67O2 cathode occurred at 4.6 V, indicating that Cu2+ doping enhances the stability of the layer structure and increases the threshold voltage. The resulting Na0.67Ni0.23Cu0.1Mn0.67O2 cathode exhibited superior electrochemical properties, demonstrating an initial reversible specific capacity of 89.1 mAh/g at a rate of 2C (360 mA g-1) and retaining more than 78 % of its capacity after 500 cycles.

9.
Sci Rep ; 13(1): 21589, 2023 Dec 07.
Artículo en Inglés | MEDLINE | ID: mdl-38062136

RESUMEN

Systems consisting of spheres rolling on elastic membranes have been used to introduce a core conceptual idea of General Relativity: how curvature guides the movement of matter. However, such schemes cannot accurately represent relativistic dynamics in the laboratory because of the dominance of dissipation and external gravitational fields. Here we demonstrate that an "active" object (a wheeled robot), which moves in a straight line on level ground and can alter its speed depending on the curvature of the deformable terrain it moves on, can exactly capture dynamics in curved relativistic spacetimes. Via the systematic study of the robot's dynamics in the radial and orbital directions, we develop a mapping of the emergent trajectories of a wheeled vehicle on a spandex membrane to the motion in a curved spacetime. Our mapping demonstrates how the driven robot's dynamics mix space and time in a metric, and shows how active particles do not necessarily follow geodesics in the real space but instead follow geodesics in a fiducial spacetime. The mapping further reveals how parameters such as the membrane elasticity and instantaneous speed allow the programming of a desired spacetime, such as the Schwarzschild metric near a non-rotating blackhole. Our mapping and framework facilitate creation of a robophysical analog to a general relativistic system in the laboratory at low cost that can provide insights into active matter in deformable environments and robot exploration in complex landscapes.

10.
Int J Biol Macromol ; 253(Pt 8): 127611, 2023 Dec 31.
Artículo en Inglés | MEDLINE | ID: mdl-37879573

RESUMEN

Extensive research has been conducted on soy protein films; however, limited information is available regarding the influence of the major components, ß-conglycinin (7S) and glycinin (11S), on the film-forming properties of soy protein. This study aimed to isolate the 7S and 11S fractions in order to prepare films and investigate the impact of varying 7S/11S ratios on the film-forming solutions (FFS) and film properties. The findings revealed that higher 11S ratios led to increased protein aggregation, consequently elevating the storage modulus (G') of the FFS. Notably, an optimal 7S/11S ratio of 7S1:11S2 (CF3) significantly enhanced the film's water resistance. Specifically, it enhanced the water contact angle by an impressive 17.44 % and reduced the water vapor transmission rate by 27.56 %. These improvements were attributed to intermolecular interactions, involving hydrogen bonds and salt bridges, between the amino acid residues of 7S and 11S. As a result, a more uniform and dense microstructure was achieved. Interestingly, the mechanical and optical properties of the film were maintained by the different protein fractions examined. In summary, this study contributes to the understanding of the film-forming properties of soy protein, particularly the role of 7S and 11S.


Asunto(s)
Globulinas , Proteínas de Soja , Proteínas de Soja/química , Glycine max/química , Globulinas/química , Antígenos de Plantas/química
11.
Mol Phylogenet Evol ; 188: 107903, 2023 11.
Artículo en Inglés | MEDLINE | ID: mdl-37574177

RESUMEN

Yersinia spp. vary significantly in their ability to cause diseases that threaten public health. Their pathogenicity is frequently associated with increasing antimicrobial resistance (AMR) and various virulence factors. The aim of the study was to investigate the AMR genes, virulence factors, and genetic diversity of Yersinia strains isolated from meats and fish in Wenzhou in 2020 by using whole-genome sequencing (WGS). A total of 50 isolates were collected. The phylogenetic relationships among the Yersinia species were also analyzed using multilocus sequence typing (MLST), core genome multi-locus sequence typing (cgMLST), and single nucleotide polymorphism (SNP) analysis. According to the results, all the strains could be classified into five species, with most isolated from beef, followed by poultry, pork, and fish. AMR genes were identified in 23 strains. And the qnrD1 genes were all located in the Col3M plasmid. Virulence genes, such as yaxA, ystB, pla, and yplA, were also found in the 15 Y. enterocolitica strains. And this study also found the presence of icm/dot type IVB-related genes in one Yersinia massiliensis isolate. MLST analysis identified 43 sequence types (STs), 19 of which were newly detected in Yersinia. Moreover, cgMLST analysis revealed that no dense genotype clusters were formed (cgMLST 5341, 5344, 5346-5350, 5353-5390). Instead, the strains appeared to be dispersed over large distances, except when multiple isolates shared the same ST. Isolates Y4 and Y26 were closely related to strains originating from South Korea and Denmark. This study showed considerable diversity in Yersinia spp. isolated from local areas (Wenzhou City). The data generated in our study may enrich the molecular traceability database of Yersinia and provide a basis for the development of more effective antipathogen control strategies.


Asunto(s)
Antibacterianos , Factores de Virulencia , Animales , Bovinos , Factores de Virulencia/genética , Tipificación de Secuencias Multilocus/métodos , Filogenia , Farmacorresistencia Bacteriana/genética , Yersinia/genética , Variación Genética , Genoma Bacteriano
12.
Front Microbiol ; 14: 1169476, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-37396356

RESUMEN

The present study investigated the water quality index, microbial composition and antimicrobial resistance genes in urban water habitats. Combined chemicals testing, metagenomic analyses and qualitative PCR (qPCR) were conducted on 20 locations, including rivers from hospital surrounds (n = 7), community surrounds (n = 7), and natural wetlands (n = 6). Results showed that the indexes of total nitrogen, phosphorus, and ammonia nitrogen of hospital waters were 2-3 folds high than that of water from wetlands. Bioinformatics analysis revealed a total of 1,594 bacterial species from 479 genera from the three groups of water samples. The hospital-related samples had the greatest number of unique genera, followed by those from wetlands and communities. The hospital-related samples contained a large number of bacteria associated with the gut microbiome, including Alistipes, Prevotella, Klebsiella, Escherichia, Bacteroides, and Faecalibacterium, which were all significantly enriched compared to samples from the wetlands. Nevertheless, the wetland waters enriched bacteria from Nanopelagicus, Mycolicibacterium and Gemmatimonas, which are typically associated with aquatic environments. The presence of antimicrobial resistance genes (ARGs) that were associated with different species origins in each water sample was observed. The majority of ARGs from hospital-related samples were carried by bacteria from Acinetobacter, Aeromonas and various genera from Enterobacteriaceae, which each was associated with multiple ARGs. In contrast, the ARGs that were exclusively in samples from communities and wetlands were carried by species that encoded only 1 to 2 ARGs each and were not normally associated with human infections. The qPCR showed that water samples of hospital surrounds had higher concentrations of intI1 and antimicrobial resistance genes such as tetA, ermA, ermB, qnrB, sul1, sul2 and other beta-lactam genes. Further genes of functional metabolism reported that the enrichment of genes associated with the degradation/utilization of nitrate and organic phosphodiester were detected in water samples around hospitals and communities compared to those from wetlands. Finally, correlations between the water quality indicators and the number of ARGs were evaluated. The presence of total nitrogen, phosphorus, and ammonia nitrogen were significantly correlated with the presence of ermA and sul1. Furthermore, intI1 exhibited a significant correlation with ermB, sul1, and blaSHV, indicating a prevalence of ARGs in urban water environments might be due to the integron intI1's diffusion-promoting effect. However, the high abundance of ARGs was limited to the waters around the hospital, and we did not observe the geographical transfer of ARGs along with the river flow. This may be related to water purifying capacity of natural riverine wetlands. Taken together, continued surveillance is required to assess the risk of bacterial horizontal transmission and its potential impact on public health in the current region.

13.
Adv Mater ; 35(39): e2304203, 2023 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-37354136

RESUMEN

The low-potential furfural oxidation reaction (FFOR) on a Cu-based electrocatalyst can produce H2 at the anode, thereby providing a bipolar H2 production system with an ultralow cell voltage. However, the intrinsic activity and stability of the Cu-based electrocatalyst for the FFOR remain unsatisfactory for practical applications. This study investigates the correlation between the valence state and the adsorption behavior of the Cu-based electrocatalyst in furfural oxidation. Cu0 is the adsorption site with low intrinsic activity. Cu+ , which exists in the form of Cu(OH)ads in alkaline electrolytes, has no adsorption ability but can improve the performance of Cu0 by promoting the adsorption of FF. Moreover, a mixed-valence Cu-based electrocatalyst (MV Cu) with high intrinsic activity and stability is prepared electrochemically. With the MV Cu catalyst, the assembled dual-side H2 production electrolyzer has a low electricity requirement of only 0.24 kWh mH2 -3 at an ultralow cell voltage of 0.3 V, and it exhibits sufficient stability. This study not only correlates the valence state with the adsorption behavior of the Cu-based electrocatalyst for the low-potential FFOR with anodic H2 production but also reveals the mechanism of deactivation to provide design principles for Cu-based electrocatalysts with satisfactory stability.

14.
J Phys Chem B ; 127(24): 5453-5461, 2023 06 22.
Artículo en Inglés | MEDLINE | ID: mdl-37290092

RESUMEN

Rh-based nanozymes show high catalytic efficiency, specific surface area, good stability, and unique physicochemical properties, while magnetic nanozymes facilitate the magnetic separation of detection samples under an external magnetic field for improved sensitivity. However, magnetic Rh nanozymes, especially those with excellent stability, have not been reported. Herein, we apply the chemical vapor deposition (CVD) method to prepare a CoRh graphitic nanozyme (termed as CoRh@G nanozyme), which structurally consists of CoRh nanoalloy encapsulated by a few layers of graphene for sensitive colorimetric sensing applications. The proposed CoRh@G nanozyme has superior peroxidase (POD)-like activity, and it shows higher affinity of the CoRh@G nanozyme than horseradish peroxidase (HRP) toward 3,3',5,5'-tetramethylbenzydine (TMB) oxidation. In addition, the CoRh@G nanozyme shows high durability and superior recyclability owing to its protective graphitic shell. The outstanding merits of the CoRh@G nanozyme allow its use for quantitative colorimetric detection of dopamine (DA) and ascorbic acid (AA), showing high sensitivity and good selectivity. Moreover, it shows satisfactory performance for AA detection in commercial beverages and energy drinks. The proposed CoRh@G nanozyme-based colorimetric sensing platform shows great promise in point-of-care (POC) visual monitoring.


Asunto(s)
Grafito , Colorimetría/métodos , Ácido Ascórbico , Peroxidasa de Rábano Silvestre , Oxidación-Reducción , Peróxido de Hidrógeno/química , Peroxidasa/química
15.
Adv Sci (Weinh) ; 10(21): e2300980, 2023 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-37144542

RESUMEN

Realizing dual charge transfer (CT) based on stable organic radicals in one system is a long-sought goal, however, remains challenging. In this work, a stable mixed-valence radical crystal is designed via a surfactant-assisted method, namely TTF-(TTF+• )2 -RC (where TTF = tetrathiafulvalene), containing dual CT interactions. The solubilization of surfactants enables successful co-crystallization of mixed-valence TTF molecules with different polarity in aqueous solutions. Short intermolecular distances between adjacent TTF moieties within TTF-(TTF+• )2 -RC facilitate both inter-valence CT (IVCT) between neutral TTF and TTF+• , and inter-radical CT (IRCT) between two TTF+• in radical π-dimer, which are confirmed by single-crystal X-ray diffraction, solid-state absorption, electron spin resonance measurements, and DFT calculations. Moreover, TTF-(TTF+• )2 -RC reveals an open-shell singlet diradical ground state with the antiferromagnetic coupling of 2J = -657 cm-1 and an unprecedented temperature-dependent magnetic property, manifesting the main monoradical characters of IVCT at 113-203 K while the spin-spin interactions in radical dimers of IRCT are predominant at 263-353 K. Notably, dual CT characters endow TTF-(TTF+• )2 -RC with strong light absorption over the full solar spectrum and outstanding stability. As a result, TTF-(TTF+• )2 -RC exhibits significantly enhanced photothermal property, an increase of 46.6 °C within 180 s upon one-sun illumination.

16.
Biosens Bioelectron ; 236: 115416, 2023 Sep 15.
Artículo en Inglés | MEDLINE | ID: mdl-37245461

RESUMEN

Nanozyme-based colorimetric assays have aroused extensive attention in biosensing due to quick response, low cost and simplicity. However, their practical applications are limited by the unsatisfactory stability and catalytic activity of nanozymes in complex detection environments. Herein, using the one-pot chemical vapor deposition method, we successfully prepare a highly efficient and stable carbon supported Co-Ir nanozyme (termed as Co-Ir/C nanozyme) for the determination of total antioxidant capacity (TAC) in food samples. The Co-Ir/C nanozyme shows excellent durability under extensive pH ranges, high temperature and high salt concentration due to the protection of carbon supporter. It can be recycled by simple magnetic separation, and its catalytic activity remains stable after long-term operation and storage. Taking full advantage of the superior peroxidase-like activity of Co-Ir/C nanozyme, it is used for colorimetric detection of ascorbic acid (or known as vitamin C), an important vitamin to adjust body's normal physiological function, with results showing higher sensitivity (detection limit of 0.27 µM) than most of the recently published works. Moreover, the determination of TAC in vitamin C tablets and fruits are further achieved, which are in good agreement with those of commercial colorimetric test kits. This study helps guide the rational preparation of versatile and highly stable nanozymes, and develops a robust TAC determination platform for future food quality monitoring.


Asunto(s)
Antioxidantes , Técnicas Biosensibles , Carbono , Técnicas Biosensibles/métodos , Ácido Ascórbico , Vitaminas , Colorimetría/métodos , Peróxido de Hidrógeno
17.
Technol Health Care ; 31(S1): 45-54, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-37038780

RESUMEN

BACKGROUND: Abdominal wall desmoid-type fibromatoses (AWDF) are occasionally encountered in clinical work, but related CT reports are rare, and most cases were misdiagnosed as malignant tumors. OBJECTIVE: We aimed to determine the diagnostic value of multislice computed tomography (MSCT) in relation to the clinical diagnosis of AWDF. METHODS: The medical records of 14 patients whose pathology results provided initial confirmation of AWDF were reviewed, and data describing their clinical characteristics, tumors' MSCT characteristics, and the condition of the surrounding tissues were analyzed and summarized retrospectively. Intraobserver and interobserver reproducibilities were evaluated. RESULTS: AWDF tended to occur in women of childbearing age (24-32 years). They occurred more frequently during the first year following pregnancy. The mean disease duration was 5.64 ± 3.78 months. All isolated tumors were growing along the musculoaponeurotic layer, and their maximum diameters were between 32 and 76 mm. Tumors' capsules were incomplete, and although the tumors infiltrated the surrounding muscles, the surrounding fat tissue and vessels were not infiltrated. None of the patients' tumors showed cystic degeneration, calcification, necrosis, or peritumoral edema. The tumors had slightly lower densities on the pre-contrast enhancement scans and mild-to-moderate enhancement after contrast enhancement. All tumors contained ribbon-like structures, and approximately 65% of the tumors encircled vascular structures. CONCLUSION: Dual-phase contrast-enhanced MSCT scans were associated with a high level of diagnostic efficacy for AWDF. The abdominal wall masses grew along the musculoaponeurotic layer, which, together with the ribbon-like structures within the tumors, should prompt clinicians to consider the presence of AWDF.


Asunto(s)
Pared Abdominal , Fibromatosis Agresiva , Embarazo , Humanos , Femenino , Adulto Joven , Adulto , Fibromatosis Agresiva/diagnóstico por imagen , Tomografía Computarizada Multidetector , Pared Abdominal/diagnóstico por imagen , Estudios Retrospectivos
18.
Proc Natl Acad Sci U S A ; 120(11): e2213698120, 2023 Mar 14.
Artículo en Inglés | MEDLINE | ID: mdl-36897978

RESUMEN

Locomotion is typically studied either in continuous media where bodies and legs experience forces generated by the flowing medium or on solid substrates dominated by friction. In the former, centralized whole-body coordination is believed to facilitate appropriate slipping through the medium for propulsion. In the latter, slip is often assumed minimal and thus avoided via decentralized control schemes. We find in laboratory experiments that terrestrial locomotion of a meter-scale multisegmented/legged robophysical model resembles undulatory fluid swimming. Experiments varying waves of leg stepping and body bending reveal how these parameters result in effective terrestrial locomotion despite seemingly ineffective isotropic frictional contacts. Dissipation dominates over inertial effects in this macroscopic-scaled regime, resulting in essentially geometric locomotion on land akin to microscopic-scale swimming in fluids. Theoretical analysis demonstrates that the high-dimensional multisegmented/legged dynamics can be simplified to a centralized low-dimensional model, which reveals an effective resistive force theory with an acquired viscous drag anisotropy. We extend our low-dimensional, geometric analysis to illustrate how body undulation can aid performance in non-flat obstacle-rich terrains and also use the scheme to quantitatively model how body undulation affects performance of biological centipede locomotion (the desert centipede Scolopendra polymorpha) moving at relatively high speeds (∼0.5 body lengths/sec). Our results could facilitate control of multilegged robots in complex terradynamic scenarios.

19.
Nanoscale ; 15(12): 5655-5664, 2023 Mar 23.
Artículo en Inglés | MEDLINE | ID: mdl-36880871

RESUMEN

Transition metal selenides are a research hotspot in sodium-ion batteries (SIBs). However, slow kinetics and rapid capacity decay due to volume changes during cycling limit their commercial applications. Heterostructures have the ability to accelerate charge transport and are widely used in energy storage devices due to their abundant active sites and lattice interfaces. A rational design of heterojunction electrode materials with excellent electrochemical performance is essential for SIBs. Herein, a novel anode material heterostructured FeSe2/MoSe2 (FMSe) nanoflower for SIBs was successfully prepared through a facile co-precipitation and hydrothermal route. The as-prepared FMSe heterojunction exhibits excellent electrochemical performance, including a high invertible capacity (493.7 mA h g-1 after 150 cycles at 0.2 A g-1), long-term cycling stability (352.2 mA h g-1 even after 4200 cycles at 5.0 A g-1) and competitive rate capability (361.2 mA h g-1 at 20 A g-1). By matching with a Na3V2(PO4)3 cathode, it can even exhibit ideal cycling stability (123.5 mA h g-1 at 0.5 A g-1 after 200 cycles). Furthermore, the sodium storage mechanism of the FMSe electrodes was systematically determined by ex situ electrochemical techniques. Theoretical calculation also reveals that the heterostructure on the FMSe interface enhances charge transport and promotes reaction kinetics.

20.
Sci Rep ; 13(1): 2910, 2023 02 19.
Artículo en Inglés | MEDLINE | ID: mdl-36801902

RESUMEN

To determine the prognostic CT features in patients with untreated thymic epithelial tumors (TETs). Clinical data and CT imaging features of 194 patients with pathologically confirmed TETs were retrospectively reviewed. The subjects included 113 male and 81 female patients between 15 and 78 years of age, with a mean age of 53.8 years. Clinical outcomes were categorized according to whether relapse, metastasis or death occurred within 3 years after the first diagnosis. Associations between clinical outcomes and CT imaging features were determined using univariate and multivariate logistic regression analyses, while the survival status was analyzed by Cox regression. In this study, we analyzed 110 thymic carcinomas, 52 high-risk thymomas and 32 low-risk thymomas. Percentages of poor outcome and patient death in thymic carcinomas were much higher than those in patients with high-risk and low-risk thymomas. In the thymic carcinomas groups, 46 patients (41.8%) experienced tumor progression, local relapse or metastasis and were categorized as having poor outcomes; vessel invasion and pericardial mass were confirmed to be independent predictors by logistic regression analysis (p < 0.01). In the high-risk thymoma group, 11 patients (21.2%) were categorized as having poor outcomes, and the CT feature pericardial mass was confirmed to be an independent predictor (p < 0.01). In survival analysis, Cox regression showed that CT features of lung invasion, great vessel invasion, lung metastasis and distant organ metastasis were independent predictors for worse survival in the thymic carcinoma group (p < 0.01), while lung invasion and pericardial mass were independent predictors for worse survival in high-risk thymoma group. No CT features were related to poor outcome and worse survival in the low-risk thymoma group. Patients with thymic carcinoma had poorer prognosis and worse survival than those with high-risk or low-risk thymoma. CT can serve as an important tool for predicting the prognosis and survival of patients with TETs. In this cohort, CT features of vessel invasion and pericardial mass were related to poorer outcomes in those with thymic carcinoma and pericardial mass in those with high-risk thymoma. Features including lung invasion, great vessel invasion, lung metastasis and distant organ metastasis indicate worse survival in thymic carcinoma, whereas lung invasion and pericardial mass indicate worse survival in high-risk thymoma.


Asunto(s)
Neoplasias Pulmonares , Neoplasias Glandulares y Epiteliales , Timoma , Neoplasias del Timo , Humanos , Masculino , Femenino , Persona de Mediana Edad , Timoma/diagnóstico , Pronóstico , Estudios Retrospectivos , Recurrencia Local de Neoplasia , Neoplasias del Timo/diagnóstico , Neoplasias Glandulares y Epiteliales/diagnóstico por imagen
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