RESUMEN
OBJECTIVE: To explore the effect of different drinking water on hepatic and renal function and zinc and iron concentrations of different organs in mice. METHODS: Zinc and iron concentrations were measured in pure water, tap water, mineral water and filtered tap-water, respectively. 80 ICR mice (half male and half female) were randomly divided into four groups and fed with pure water (control group), tap water, mineral water and filtered tap-water, respectively. After 90 days, blood samples were taken from the eyeballs of mice. The contents of serum ALT, TP, BUN, UA and Cr were analyzed. Then mice were killed and livers, kidneys, hearts, pancreas, brains were removed immediately to determinate zinc and iron concentrations. Simultaneously morphological changes of liver and kidney paraffin section were observed. RESULTS: Contents of serum Cr in filtered tapwater group (36. 00 ± 8. 83 µmol/L) were lower than those of pure water group(44. 83 ± 12. 64 µmol/L), tap water group (44. 56 ± 10. 52 µmo/L) and mineral water group (43. 79 ± 10. 53 µmol/L) (P < 0. 05). The zinc concentrations of livers and kidneys (33. 17 ± 6. 18 and 16. 69 ± 8. 12 µg/g) in pure water group was lower than that of filtered tap-water group 45. 31 ± 7. 32 and 22. 61± 6. 01µg/g) P < 0. 05). A significant negative correlation (r = - 0. 300) emerged between the serum Cr and the zinc concentration of kidney in mice P < 0. 05). CONCLUSIONN: Long-term drinking filtered tap-water is beneficial to the glomerular filtration barrier, and it may be related to the increase of zinc levels in kidney.