Biomaterial based implants caused remote liver fatty deposition through activated blood-derived macrophages.

Understanding the biocompatibility of biomaterials is a prerequisite for the prediction of its clinical application, and the present assessments mainly rely on in vitro cell culture and in situ histopathology. However, remote organs responses after biomaterials implantation is unclear. Here, by leveraging body-wide-transcriptomics data, we performed in-depth systems analysis of biomaterials - remote organs crosstalk after abdominal implantation of polypropylene and silk fibroin using a rodent model, demonstrating local implantation caused remote organs responses dominated by acute-phase responses, immune system responses and lipid metabolism disorders. Of note, liver function was specially disturbed, defined as hepatic lipid deposition. Combining flow cytometry analyses and liver monocyte recruitment inhibition experiments, we proved that blood derived monocyte-derived macrophages in the liver underlying the mechanism of abnormal lipid deposition induced by local biomaterials implantation. Moreover, from the perspective of temporality, the remote organs responses and liver lipid deposition of silk fibroin group faded away with biomaterial degradation and restored to normal at end, which highlighted its superiority of degradability. These findings were further indirectly evidenced by human blood biochemical ALT and AST examination from 141 clinical cases of hernia repair using silk fibroin mesh and polypropylene mesh. In conclusion, this study provided new insights on the crosstalk between local biomaterial implants and remote organs, which is of help for future selecting and evaluating biomaterial implants with the consideration of whole-body response.

Science of perception, decision making and fatigue in the maritime industry.

In this paper, we investigate how perception, decision making and fatigue affect safety in the maritime industry. With maritime safety incidents often having disastrous effects on the lives of the seafarers, the natural environment, and the industry as a whole, a better understanding of the science behind the human errors is necessary to increase safety at sea. We conducted interviews and real time observations of seafarers, and we combine our findings with a review of relevant academic literature with the aim of using scientific knowledge to address a real-world problem. We conclude that the seafarers consistently work at the limits of their cognitive abilities and that better care for their wellbeing is crucial for safety at sea. It is hoped that this study will be beneficial to the practitioners in the field of the maritime industry as well as psychologists studying the effects of long term, high cognitive loads in the work environment.