RESUMEN
OBJECTIVE: Hepatitis C virus (HCV) infection is a high morbidity disease in China. The aim of this study was to explore the latest distribution of HCV genotypes in China, mainly focusing on epidemiological characteristics and risk factors of HCV genotype 1 in Chinese Han population. PATIENTS AND METHODS: 793 HCV-positive patients were enrolled from 21 hospitals across China. The association of epidemiological data with HCV genotype 1 and the potential risk factors was analyzed using univariate and multivariate logistic regression analysis. RESULTS: The HCV genotype 1b was detected in 66.9% of 793 patients. The way of infection, disease course, HCV RNA level, history of blood transfusion and smoking were found to be significantly different between patients infected with HCV genotype 1 and non-genotype 1. The result of univariate logistic regression analysis showed that HCV genotype 1 infection has a close relationship with age, gender, smoking history, the way of infection, allergy, disease course, and HCV RNA level. Moreover, the HCV RNA level, disease course, and blood transfusion history were the related risk factors for infection of HCV genotype 1 as demonstrated by multivariate logistic regression analysis. CONCLUSIONS: The HCV genotype 1 was still the main genotype of HCV infection in China. We should intensify HCV screening for those people who aged over 50 years and had a history of blood transfusion in China. The treatment of genotype 1 should be paid more attention in antiviral of HCV.
Asunto(s)
Pueblo Asiatico/genética , Genotipo , Hepacivirus/genética , Hepatitis C/epidemiología , Hepatitis C/genética , Vigilancia de la Población , Adulto , China/epidemiología , Femenino , Hepatitis C/diagnóstico , Humanos , Masculino , Persona de Mediana Edad , Vigilancia de la Población/métodos , Prevalencia , Factores de Riesgo , Encuestas y CuestionariosRESUMEN
UNLABELLED: The treatment effect of 101 non-variceal bleeding(NVB) patients treated with pantoprazole was observed, and it was compared with 57 NVB patients treated with omeprazole. RESULTS: 87.1% of the patients in 48 h and 97% of the patients in 72 h with Pantoprazole bleeding-stopped. And the result was almost equal to omeprazole group. The side-effect of pantoprazole was few and slight. It is suggested that pantoprazole is effective and safe on treating NVB.
Asunto(s)
Antiulcerosos/uso terapéutico , Bencimidazoles/uso terapéutico , Úlcera Duodenal/complicaciones , Úlcera Péptica Hemorrágica/tratamiento farmacológico , Úlcera Gástrica/complicaciones , Sulfóxidos/uso terapéutico , 2-Piridinilmetilsulfinilbencimidazoles , Adulto , Femenino , Humanos , Masculino , Persona de Mediana Edad , Omeprazol/análogos & derivados , Pantoprazol , Úlcera Péptica Hemorrágica/etiologíaRESUMEN
A unique patient with type VIII Ehlers-Danlos syndrome and cutaneous vasculitis, resorptive osteolysis, and cardiac valvular disease is described. Collagen analyses identified morphologic and physical abnormalities of type I collagen. The patient's T lymphocytes could be propagated in vitro with type I collagen and produced a 60-kd lymphokine that bound this protein. Cellular autoimmunity to type I collagen may be responsible for this patient's intractable clinical condition.