[A case of favourable outcome of severe acute intoxication with an animal poison after a bite by the monocled cobra].

This paper reports a case of severe acute intoxication with an animal poison after a bite by the monocled cobra. Combined treatment including artificial lung ventilation, infusion-detoxication and desensitizing (hormonal) therapy, hemosorption, correction of metabolic disorders with cytoflavin, antibacterial therapy had positive effect on the patient's condition and ensured the favourable outcome ofpotentially lethal poisoning without the use ofa specific anti-snake venom serum.

[Effect of cytoflavin on some physiological values in patients with toxicohypoxic encephalopathy].

The effect of cytoflavin upon bolus intravenous administration on the state of hemodynamic values and liquid sectors of the organism was studied in patients with toxicohypoxic encephalopathy caused by heavy acute poisoning. It is established that the bolus administration of cytoflavin is less effective than dropwise intravenous injection.

[Correction of tissue hypoxia with reamberin in severe forms of acute intoxication with neurotropic poisons].

Examination and treatment of 66 patients severely intoxicated with neurotropic poisons showed that inclusion of reamberin in combined therapy decreased the degree of tissue hypoxia as apparent from increased oxygen consumption, oxygen utilization index, and arteriovenous oxygen difference. This in turn accelerated recovery of antioxidant protection and lowered activity of lipid peroxidation. The use of reamberin for the treatment of acute neurotropic intoxication improves clinical conditions of the patients by decreasing duration of the comatose state, requirement for intensive therapy, and lethality.

[Pharmacological correction of hypoxic and free-radical disorders in patients with acute myocardial infarction complicated by acute heart failure].

Results of the evaluation of clinical findings in a group of 36 patients with acute myocardial infarction (AMI) complicated by acute heart failure (AHF) of class II - IV [according to T. Killip and J. Kimball (1967)] show that the use of cytoflavin and perftoran favors a decrease in the patient critical situation length, duration of patient's stay in hospital, and lethality level. It is established that these drugs lead to a decrease in the depth of hypoxia and lipid peroxidation in tissues, improves oxygen utilization, and restores antioxidant system activity in AMI/AHF patients.

[The diagnosis and treatment of pulmonary hyperhydration in critically ill patients with acute poisoning by neurotropic agents].

Examination of 784 patients with acute intoxication with neurotropic agents yielded criteria for a risk of acute lung injury in this pathology and methods for diagnosing and treating this complication.

[Cerebral hypoxic lesions in the early phase of acute intoxications with neurotropic poisons: development, course, and ways of correction].

The paper presents the results of examination and treatment of 147 patients in the early phase of severe acute intoxications with neurotropic poisons. The use of the methods of assessing the bioelectrical activity of the brain has been found to objectively evaluate the degree of CNS suppression, to clarify the nature of the damaging action of a toxic agent, and to evaluate the efficiency of therapy. The use of cytoflavin in intensive care for cerebral hypoxic lesions has been shown to substantially decrease the degree of brain lesions.

[Method of pharmacological treatment of the consequences of hypoxia in critically ill patients with acute poisoning]. / Puti farmakologicheskoi korrektsii posledstvii gipoksii pri kriticheskikh sostoianiiakh u bol'nykh s ostrymi otravleniiami

The multi-factor effect of pharmacological preparations reamberine and citotoflavine, which contain succinate, in critical conditions is preconditioned by the impact they produce on a total energy deficit caused by a long-term hypoxia. The correction of energy deficit improves the therapy of patients in coma, which resulted from poisonings by neurotropic substances. The therapeutic effect manifested itself through a shorter state of coma from 25 to 12.5%. However, an analysis of died patients, who received the metabolic antihypoxants, showed that these drugs are not effective, when the time lapse from poisoning to medical aid exceeded 20 hours. When perftoran, a corrector of oxygen transport, and antihypoxant cytoflavin were added to the therapy scheme, it resulted in that 22 of 24 patients, who were also taken to clinic in the state of coma after 20 and more hours, survived, while all patients in the comparison group (20 patients) died despite an intensive therapy.

[Drug correction of hypoxia aftereffects in patients with toxic coma caused by acute neurotropic poisoning]. / Farmakologicheskaia korrektsiia podsledstvii gipoksii u bol'nykh v toksicheskoi kome vsledstvie ostrykh otravlenii iadami neirotropnogo deistviia.

Seventy-eight patients with acute neurotropic poisoning (soporifics, neuroleptics, antidepressants, ethanol and its surrogates, narcotics) were examined and treated. Study of the pathogenesis of hypoxic injuries in acute neurotropic poisoning demonstrated the efficiency of using Perfluorane, an infusion solution with oxygen transporting functions, and Cytoflavine, a substrate antihypoxant, for correction of the detected disorders.

[Role of abnormalities of the lung surfactant system in the development of respiratory failure in critical states caused by acute neurotoxic poisoning]. / Rol' patologii surfaktantnoi sistemy legkikh v razvitii dykhatel'noi nedostatochnosti pri kriticheskikh sostoianiiakh, obuslovlennykh ostrymi otravleniiami iadami neirotoksicheskogo deistviia.

Clinical data on the surfactant system of the lungs during poisoning with neurotoxic toxins are presented and approaches to drug correction of lung system disorders in severe intoxication with neurotoxic agents are offered.

[Correction of free radical processes by a succinic acid drug (reamberine) in intensive care of patients with acute neurotropic poisoning]. / Korrektsiia svobodnoradikal'nykh protsessov preparatom iantarnoi kisloty (reamberinom) v intensivnoi terapii ostrykh otravlenii neirotropnymi iadami.

Sixty-six patients with acute poisonings with neurotropic toxins (soporiphics, neuroleptics, antidepressants, ethanol and its surrogates) were examined and treated. Clinical data and correction of disorders in free-radical processes in acute poisonings with these toxins indicate the efficiency of adding reamberine to combined therapy of this patient population.