Asunto(s)
Terapia de Inmunosupresión/métodos , Síndrome de Susac/complicaciones , Síndrome de Susac/inmunología , Adulto , Ciclofosfamida/uso terapéutico , Femenino , Humanos , Inmunoglobulinas Intravenosas/uso terapéutico , Estudios Longitudinales , Imagen por Resonancia Magnética , Metilprednisolona/uso terapéutico , Síndrome de Susac/diagnóstico por imagenRESUMEN
Tissue polypeptide antigen (TPA) has been detected by immunocytochemical assay on urine cytological samples from 28 asymptomatic patients, who previously had a histological diagnosis of papillary transitional cell carcinoma (PTCT) of the urinary bladder (UB), in order to evaluate its role in follow-up controls. TPA staining intensity (SI) in urothelial cells was evaluated to improve the diagnostic accuracy of cytology. Differentiated tumor cells were strongly stained for TPA, heavier than normal urothelial cells. Undifferentiated neoplastic cells were less stained for TPA with a wide range of SI. TPA detection revealed positive cytology in 21 (75%) of the considered cases. The accuracy of our cytological findings compared with both routine examinations and subsequent histopathological diagnosis was of 95.2%. Follow-up urinary cytology limits could be reduced by TPA searching in differentiated tumor cells, deriving from low-grade neoplasms.
Asunto(s)
Antígenos de Neoplasias/análisis , Biomarcadores de Tumor/análisis , Péptidos/análisis , Neoplasias de la Vejiga Urinaria/diagnóstico , Anciano , Estudios de Seguimiento , Humanos , Inmunohistoquímica , Persona de Mediana Edad , Péptidos/inmunología , Antígeno Polipéptido de Tejido , Neoplasias de la Vejiga Urinaria/inmunologíaRESUMEN
Tissue polypeptide antigen (TPA) both in normal and neoplastic urinary bladders has been studied by immunocytochemistry. A comparison of TPA with epithelial membrane antigen (EMA), keratins and carcinoembryonic antigen (CEA) in various tumor grades and stages has been performed better to define TPA role in bladder carcinomas. Well-differentiated tumors were strongly stained for TPA with a uniform staining intensity. Undifferentiated tumors were weakly stained for TPA with an uneven staining intensity. There was no relation between TPA findings and stages of invasion. However, TPA seems to be a very helpful diagnostic tool for tumor grading and staging.
Asunto(s)
Antígenos de Neoplasias/análisis , Carcinoma de Células Transicionales/inmunología , Péptidos/análisis , Neoplasias de la Vejiga Urinaria/inmunología , Vejiga Urinaria/inmunología , Adulto , Anciano , Biopsia , Carcinoma de Células Transicionales/diagnóstico , Epitelio/análisis , Humanos , Queratinas/análisis , Persona de Mediana Edad , Estadificación de Neoplasias , Pronóstico , Coloración y Etiquetado , Antígeno Polipéptido de Tejido , Neoplasias de la Vejiga Urinaria/diagnóstico , Neoplasias de la Vejiga Urinaria/patologíaRESUMEN
Nephrogenic adenoma is a rare lesion of urothelial mucous membrane. At present, the cases described in literature are 85. In this work the Authors study the morphologic aspects and etiopathogenetic theories.
Asunto(s)
Adenoma/patología , Neoplasias Urológicas/patología , HumanosAsunto(s)
Hiperparatiroidismo Secundario/terapia , Glándulas Paratiroides/cirugía , Diálisis Renal/efectos adversos , Adulto , Anciano , Fosfatasa Alcalina/metabolismo , Calcio/uso terapéutico , Femenino , Humanos , Hipocalcemia/terapia , Fallo Renal Crónico/complicaciones , Masculino , Persona de Mediana Edad , Glándulas Paratiroides/trasplante , Hormona Paratiroidea/sangreRESUMEN
The urological complications after a renal transplantation still represent an event anything but rare, ranging, according to the different statistics, from 0.9% up to 23%, with a mortality between 0 and 25%. In this work done by the Verona Centre the experience on 274 transplantations is reported. The urological complications weighed with 6.2% and absence of mortality among the patients. The importance of the prevention and precocious diagnosis is confirmed.