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Sheng Wu Gong Cheng Xue Bao ; 40(5): 1293-1308, 2024 May 25.
Artículo en Chino | MEDLINE | ID: mdl-38783798

RESUMEN

The intestinal microbiota exhibits a strong correlation with the function of the central nervous system, exerting influence on the host brain through neural pathways, immune pathways, and microbial metabolites along the gut-brain axis. Disorders in the composition of the intestinal microbial are closely associated with the onset and progression of neurological disorders, such as depression, Alzheimer's disease, and Parkinson's disease. It has been proven that fecal microbiota transplantation can improve symptoms in animal models of neurological diseases and clinical patients. This paper provides a comprehensive review of the composition and function of the human intestinal microbiota, as well as the intricate the relationship between the human intestinal microbiota and nervous system diseases through the gut-brain axis. Additionally, it delves into the research advancements and underlying mechanism of fecal microbiota transplantation in the treatment of nervous system diseases. These findings offer novel insights and potential avenues for clinical interventions targeting nervous system diseases.


Asunto(s)
Trasplante de Microbiota Fecal , Microbioma Gastrointestinal , Enfermedades del Sistema Nervioso , Humanos , Animales , Enfermedades del Sistema Nervioso/terapia , Enfermedades del Sistema Nervioso/microbiología , Eje Cerebro-Intestino , Enfermedad de Parkinson/terapia , Enfermedad de Parkinson/microbiología , Enfermedad de Alzheimer/terapia , Enfermedad de Alzheimer/microbiología , Depresión/terapia , Depresión/microbiología
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