Asunto(s)
Procedimientos Quirúrgicos de Citorreducción/métodos , Leucemia Mielomonocítica Crónica/complicaciones , Leucocitosis/fisiopatología , Insuficiencia Multiorgánica/cirugía , Estudios de Seguimiento , Humanos , Insuficiencia Multiorgánica/etiología , Insuficiencia Multiorgánica/mortalidad , Insuficiencia Multiorgánica/patología , Pronóstico , Estudios Retrospectivos , Tasa de SupervivenciaRESUMEN
Renal cell carcinoma exome-derived, V(D)J recombination reads had an elevated presence and variability, for both TcR-α and -ß, when compared to marginal tissue, reflecting an opportunity to assess tumor immunogenicity by comparison with marginal tissue T cells. PD-1, PD-L2, CTLA4 and FOXP3, all of which are implicated in the evasion of an anti-tumor immune response, had a significantly higher expression for samples representing co-detection of productive TcR-α and -ß recombination reads. Samples representing tumors with productive TcR-α recombination reads but no detectable, productive TcR-ß recombination reads, reflected a 20% survival advantage, and RNASeq data indicated an intermediate level of immune checkpoint gene expression for those samples. These results raise the question of whether relatively high levels of detection of productive TcR-α recombination reads, in comparison with detection of reads representing the TcR-ß gene, identify a microenvironment that has not yet entered a T-cell exhaustion phase and may thereby represent conditions for immune enhancements that do not require anti-immune checkpoint therapies.
Asunto(s)
Biomarcadores de Tumor/genética , Carcinoma de Células Renales/genética , Exoma/genética , Neoplasias Renales/genética , Receptores de Antígenos de Linfocitos T alfa-beta/genética , Recombinación Genética/genética , Linfocitos T/inmunología , Algoritmos , Biomarcadores de Tumor/inmunología , Carcinoma de Células Renales/inmunología , Humanos , Neoplasias Renales/inmunología , ARN Mensajero/genética , Receptores de Antígenos de Linfocitos T alfa-beta/inmunología , Recombinación Genética/inmunología , Análisis de Secuencia de ARNRESUMEN
Märta Tikkanen's poetry collection Århundradets kärlekssaga (The love story of the century, 1978) is a confessional book on life in a family where the husband and father is an alcohol abuser. It is also a love story about a married couple who love one another despite the terrible challenges posed to the relationship by alcoholism. The poetry collection became one of the most influential books in contemporary Nordic fiction, its themes on gender roles and alcohol abuse setting the trend in the Nordic discussion of women's liberation. Märta Tikkanen's courage to tell her own private story inspired other women to confess their gender equality problems to the public. The alcohol abuse of Märta Tikkanen's husband Henrik Tikkanen was seen as an allegory for the more general problems in the relation between men and women. My essay introduces Märta Tikkanen's poetry collection and discusses how the poems develop the theme of gender and alcohol. I will also compare her description of their marriage with Henrik Tikkanen's self-portrait in his autobiographical novella Mariegatan 26, Kronohagen (1977). The analysis refers to contemporary research on gender and alcohol abuse and discusses how the poems contribute to a public recognition of the relationship between gender and alcohol abuse. The essay discusses the reception of Märta Tikkanen's influential poems and explores her treatment of alcohol and gender in relation to other Nordic confessional or fictional books on alcohol abuse.