RESUMEN
The cases of three patients who developed diabetes mellitus (DM) within 2-3 weeks of acute hepatitis A virus (HAV) infection associated with diabetic ketoacidosis are reported. The ketoacidosis was considered an index of insulin dependent diabetes mellitus most likely precipitated by the acute virus infection.
Asunto(s)
Diabetes Mellitus Tipo 1/etiología , Cetoacidosis Diabética/etiología , Hepatitis A/complicaciones , Adulto , Glucemia/análisis , Niño , Diabetes Mellitus Tipo 1/sangre , Diabetes Mellitus Tipo 1/tratamiento farmacológico , Cetoacidosis Diabética/sangre , Cetoacidosis Diabética/tratamiento farmacológico , Femenino , Hepatitis A/sangre , Anticuerpos Antihepatitis/sangre , Humanos , Insulina/uso terapéuticoRESUMEN
Intestinal calcium absorption and plasma levels of 1,25-dihydroxycholecalciferol (1,25(OH)2D3) were measured in lactating and non-lacting rats and the effects of bromocriptine and exogenous prolactin treatment were evaluated. In lacting rats calcium absorption and plasma levels of parathyroid hormone, 1,25(OH)2D3 and alkaline phosphatase activity were significantly increased. Bromocriptine treatment significantly reduced the enhanced calcium absorption and levels of plasma 1,25(OH)2D3 and alkaline phosphatase but had no significant effect on plasma levels of parathyroid hormone. Prolactin administered with bromocriptine to lactating animals prevented all the changes observed with bromocriptine treatment alone. It was concluded that the increased plasma levels of prolacting during lactation lead to high plasma levels of 1,25(OH)2D3 which are responsible for the enhanced intestinal calcium absorption.
Asunto(s)
Calcitriol/metabolismo , Calcio/metabolismo , Lactancia , Prolactina/farmacología , Fosfatasa Alcalina/sangre , Animales , Bromocriptina/farmacología , Calcitriol/sangre , Femenino , Absorción Intestinal/efectos de los fármacos , Masculino , Embarazo , Ratas , Ratas EndogámicasRESUMEN
The results of a cross-sectional anthropometric survey of Sudanese children up to the age of thirteen years and six months is reported. Children in whom a quick clinical examination revealed pathology were excluded, as were children who did not have a true birth certificate. Height, weight and mid-arm circumference were measured in all children, head and chest circumference were measured in children up to the age of 5 years and 6 months. Skinfold thickness at biceps, triceps, subscapular and suprailiac sites were measured in children above the age of 30 months. The children were found to be shorter and lighter, and to have less subcutaneous fat than British children. The findings are also compared with those from other African populations. Comparison with a survey performed in the same village seven years earlier reveals that the heights and weights of the children have hardly changed despite a considerable improvement in economic status. The children have a lower weight for height than British and other African populations.