RESUMEN
Background and Aims: The acute tropical infectious disease known as yellow fever (YF) is caused by an arbovirus and is characterized by fever, jaundice, hemorrhage, headache, muscle pain, nausea, vomiting, and fatigue. Angola experienced a yellow fever virus (YFV) outbreak that was documented in December 2015. However, little is known about the outcome of this outbreak. We aimed to demonstrate epidemic features and lessons learned during the YF epidemic in Angola. Methods: A total of 4618 blood samples from suspected YF cases were sent to the Instituto Nacional de Investigação em Saúde (INIS), a national referral and public health laboratory, between December 5, 2015, and December 23, 2016. Sample analyses were conducted using enzyme-linked immunosorbent assay (ELISA) and reverse transcription polymerase chain reaction (RT-PCR) assays. Blood samples were sent from 16 out of the 18 provinces of Angola. Results: We detected 884 (19.1%) cases that were positive for ELISA, which were confirmed by RT-PCR assay. Considering the positive cases, the incidence among male patients was around three times higher (n = 223; 10.9%) than in female patients (n = 59; 2.6%) in the 20-29 age group, followed by the age group 10-19 with n = 211 (6.8%) in males versus n = 108 (3.3%) in females; and the age group 30-39 had n = 68 (4.8%) in males versus n = 28 (1.8%) in females. The other groups had an incidence below 3.0%. The case fatality ratio for YF was in young adults in the age group 20-29 with n = 39 cases, followed by the age group 10-19 with n = 16 cases, and finally the age group 0-9 with n = 13 cases. The other age groups had several deaths by YF below 10 cases. Conclusions: This study demonstrates features of the YF epidemic that occurred in Angola. Also, it demonstrates that YF causes deaths in young people but is preventable by high vaccine coverage. Thus, public health laboratory surveillance must be strengthened to reduce the possibility of emerging and re-emerging human infections.
RESUMEN
Por su alto riesgo reproductivo, se analizó la protección anticonceptiva en un grupo de 42 mujeres portadoras de distrofia muscular tipo Duchenne (DMD), así como en un grupo control. Del total de las mujeres estudiadas, 26(61.9 por ciento) tuvieron hijos distróficos. El grupo de portadoras tuvo el doble del número de hijos que el grupo control. La cobertura anticonceptiva fue de 67.0 por ciento en las mujeres portadoras y 82.3 por ciento en el grupo control. Los métodos anticonceptivos eficaces fueron poco utilizados por las portadoras (dispositivo intrauterino 14 por ciento y método quirúrgico 39 por ciento). Estos resultados señalan que se requiere extender el programa de detección de portadoras y establecer uno de vigilancia epidemiológica que incluya un enfoque de protección anticonceptiva del alto riesgo reproductivo expecífico (PARE), con el propósito de disminuir la incidencia de hijos afectados, los altos costos y evitar el enorme sufrimietno que ocasiona a las pacientes y a sus familiares la distrofia muscular tipo Duchenne