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2.
Nutrients ; 10(8)2018 Aug 04.
Artículo en Inglés | MEDLINE | ID: mdl-30081576

RESUMEN

A subset of patients with celiac disease (CD) on a gluten-free diet (GFD) reported the persistence of functional gastrointestinal disorders. Foods containing fermentable, oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) can trigger a broad range of gastrointestinal symptoms in sensitive individuals. We evaluated the effects of a low FODMAP diet (LFD) on gastrointestinal and psychological symptomatology in CD patients. A total of 50 celiac patients on GFDs and with persistence of gastrointestinal symptoms were included. The patients were randomly allocated to one of two dietary groups-one on a low FODMAP GFD (LF-GFD, n = 25) and the other on a regular GFD (R-GFD, n = 25)-for 21 days. Psychological symptomatology and quality of life were evaluated by the Symptom Checklist-90-R (SCL-90) and the Short Form (36) Health Survey (SF-36) questionnaires, respectively. Gastrointestinal symptomatology and general well-being were evaluated by visual analogue scale (VAS) scores. After 21 days, 21 and 23 patients completed the dietary treatment on LF-GFD and R-GFD, respectively. A reduced global SCL-90 index (p < 0.0003) was found in the LF-GFD group but not in the R-GFD one. However, the SF-36 scores did not differ between groups after treatment. The VAS for abdominal pain was much lower, and the VAS for fecal consistency enhanced after treatment in the LF-GFD group. General well-being increased in both groups but with a much higher improvement in the LF-GFD (p = 0.03). A short-term LFD regimen helps to improve the psychological health and gastrointestinal symptomatology with enhanced well-being of CD patients with persisting functional gastrointestinal symptomatology. The long-term clinical effects of LFD in particular subgroups of CD patients need further evaluation.


Asunto(s)
Enfermedad Celíaca/dietoterapia , Dieta Baja en Carbohidratos , Dieta Sin Gluten , Salud Mental , Adulto , Enfermedad Celíaca/diagnóstico , Enfermedad Celíaca/fisiopatología , Enfermedad Celíaca/psicología , Digestión , Método Doble Ciego , Femenino , Fermentación , Estado de Salud , Humanos , Italia , Masculino , Persona de Mediana Edad , Calidad de Vida , Inducción de Remisión , Factores de Tiempo , Resultado del Tratamiento
3.
Med Eng Phys ; 27(1): 13-8, 2005 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-15604000

RESUMEN

Intravascular stents are small tube-like structures expanded into stenotic arteries to restore blood flow perfusion to the downstream tissues. The stent expansion is an important factor to define the effectiveness of the surgical procedure: it depends on the stent geometry and includes large displacements and deformations, geometric and material non-linearity. Numerical analyses seem appropriate to study such a complex behaviour after a free stent expansion. In this study the finite element method (FEM) was applied to a new generation coronary stent. Results from computations were compared with those from a laboratory experiment in terms of radial expansion and elastic recoil. By means of a scanning electronic microscopy the area of plastic deformation were also detected and compared with those obtained in the numerical simulation. Matching between the different measurements was quite satisfactory even if some discrepancies were present due to the absence of the balloon in the numerical model.


Asunto(s)
Angioplastia Coronaria con Balón/instrumentación , Vasos Coronarios/fisiopatología , Vasos Coronarios/cirugía , Diagnóstico por Computador/métodos , Análisis de Falla de Equipo/métodos , Modelos Cardiovasculares , Stents , Angioplastia Coronaria con Balón/métodos , Prótesis Vascular , Simulación por Computador , Elasticidad , Análisis de Elementos Finitos , Humanos , Pronóstico , Estrés Mecánico , Resultado del Tratamiento
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