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INTRODUCTION AND IMPORTANCE: The predominant variant of skin cancer is Basal cell carcinoma (BCC), constituting about 80 % of all non-melanoma skin cancers on a global scale. Typically, it manifests on skin surfaces that are frequently exposed to sunlight, such as the neck, face, and ears. CASE PRESENTATION: A 65-year-old man presented to a specialized cancer hospital with a large pigmented lesion on the left cheek that had gradually increased in size for about a year. The tumor had become raised and ulcerated, which necessitated deep surgery on his face due to extensive invasion of BCC was done. CLINICAL DISCUSSION: Basal cell carcinoma is a slow-growing, locally invasive cancerous tumor of the basal cells of the skin, which line the deepest layer of the epidermis. BCC often occurs on areas of the body that are exposed to the sun. It develops in response to cumulative UV irradiation and sporadic UV irradiation, as occurs with sunburns. CONCLUSION: BCC is a common and potentially devastating skin cancer that primarily affects fair-skinned people over the age of 50. Lesions on the face can be particularly challenging. Early detection and treatment is critical to minimize the need for extensive excision and reconstruction.
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INTRODUCTION AND IMPORTANCE: Ewing's sarcoma, a highly malignant bone tumor, typically affects the pelvis and long bones of the lower extremities in children and young adults; primary involvement of the skull is rare. Primary Ewing's sarcoma arising from the skull is very rare. In most cases, this disease is fatal, although the prognosis of Ewing sarcoma improves with radiation and chemotherapy after surgery. CASE PRESENTATION: This case is about 25-year-old woman who was referred to Omid Hospital in Urmia because of frequent headaches, where a tumor mass was found according to the results of CT scan. Biopsy confirmed small round cell sarcoma as the diagnosis. Chemotherapy was ineffective and tumor growth was unstoppable, causing the patient to die after 3 months. CLINICAL DISCUSSION: Ewing's sarcoma can affect various parts of the human body, including bone and soft tissue, but rarely the skull. Ewing's sarcoma typically grows extradural and often reaches a very large size before invading the skull or being detected clinically. CONCLUSION: In most cases, Ewing's sarcoma is fatal, although the prognosis of this disease improves with radiation and chemotherapy after surgery.
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INTRODUCTION AND IMPORTANCE: Cutaneous squamous cell carcinoma (CSCC) is one of the most common malignant tumors of skin cancer. Most of these cancers occur on the head and neck. CSCC makes up the seventh most common type of cancer worldwide. The incidence of human papillomavirus (HPV)-associated head and neck squamous cell carcinoma became more prevalent, and HPV infection is mainly linked to head and neck squamous cell carcinoma (HNSCC). CASE PRESENTATION: A 57-year-old non-smoking man was admitted to Omid Hospital in Urmia, West Azerbaijan, Iran; there were extensive bleeding masses on his head and neck due to squamous cell carcinoma (SCC), and he has been diagnosed with HPV infection so accidentally. The operation room had prepared for excisional treatment and the masses had been removed as much as possible. Patient was referred to the wound care team to receive advanced treatment interventions. CLINICAL DISCUSSION: Incidence of HPV-associated HNSCC has been more noticeable recently, and HPV infection alone can be a distinct risk factor for metastatic HNSCC. Most patients with HPV positive have peripheral lymph node involvement. Radiation therapy and surgery can offer equally good long-term results in small initial head and neck tumors. Traditionally, advanced head and neck tumors managed surgically more advantageous. CONCLUSION: This case illustrates that history of HPV positive can be associated with a more severe and resistant type of HNSCC with poor treatment outcomes. Patients with HPV should be monitored regularly for HNSCC, and treatment should be started as soon as possible for a better result.