RESUMEN
OBJECTIVES: This study aimed to assess posttransplant changes in insulin sensitivity and ß-cell function of pancreas transplant recipients according to the type of diabetes mellitus (DM) and the pretransplant insulin sensitivity measured by the Matsuda Index (MI). METHODS: We analyzed 60 patients who underwent pancreas transplantation and oral glucose tolerance test pretransplant and at 1 month posttransplant. RESULTS: At 1 month posttransplant, insulin sensitivity did not show significant improvement; particularly, the MI was significantly lower after transplant in recipients with type 1 DM (T1DM) and those with pretransplant MI of 5 or greater. ß-cell function was significantly improved after transplant in all recipients regardless of the type of DM and pretransplant MI values. Glucose control was significantly improved in recipients with T1DM and in all recipients regardless of the pretransplant MI values. Additional oral glucose tolerance test at 1 year posttransplant revealed that insulin sensitivity remained unimproved and ß-cell function was higher compared with pretransplant. Glucose control had partially reverted to pretransplant levels in recipients with T1DM and those with pretransplant MI of 5 or greater. CONCLUSIONS: Unlike ß-cell function and glucose control, insulin sensitivity did not significantly improve until posttransplant 1 year after pancreas transplantation regardless of the type of DM or the degree of pretransplant insulin sensitivity.
Asunto(s)
Inhibidores de la Calcineurina/metabolismo , Prueba de Tolerancia a la Glucosa/métodos , Resistencia a la Insulina , Células Secretoras de Insulina/metabolismo , Trasplante de Páncreas/métodos , Adulto , Glucemia/metabolismo , Inhibidores de la Calcineurina/farmacocinética , Inhibidores de la Calcineurina/uso terapéutico , Ciclosporina/metabolismo , Ciclosporina/farmacocinética , Ciclosporina/uso terapéutico , Diabetes Mellitus Tipo 1/sangre , Diabetes Mellitus Tipo 1/metabolismo , Diabetes Mellitus Tipo 2/sangre , Diabetes Mellitus Tipo 2/metabolismo , Femenino , Glucagón/sangre , Glucagón/metabolismo , Humanos , Insulina/sangre , Insulina/metabolismo , Células Secretoras de Insulina/efectos de los fármacos , Estimación de Kaplan-Meier , Masculino , Persona de Mediana Edad , Tacrolimus/metabolismo , Tacrolimus/farmacocinética , Tacrolimus/uso terapéuticoRESUMEN
Here, we report the complete genome sequence of a bovine viral diarrhea virus (BVDV) belonging to genotype 1d, strain 10JJ-SKR, which was isolated from cattle. The complete genome is 12,267 nucleotides (nt) in length, with a single large open reading frame. This is the first report of a BVDV belonging to genotype 1d and will enable further study of the molecular and epidemiological characteristics of this virus.