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1.
Nutrients ; 15(3)2023 Jan 18.
Artículo en Inglés | MEDLINE | ID: mdl-36771210

RESUMEN

L-fucose (Fuc), a monosaccharide with different biological functions in various organisms, exhibits potent anti-obesity effects in obese mice. However, the mechanisms underlying its anti-obesity effects remain largely unknown. In this study, we aimed to investigate the effects of Fuc on lipid metabolism and insulin signaling in 3T3-L1 adipocytes. We found that Fuc treatment suppressed lipid accumulation during adipocyte differentiation. Additionally, Fuc treatment enhanced the phosphorylation of AMP-activated kinase (AMPK) and its downstream pathways, responsible for the regulation of fatty acid oxidation and lipolysis. Furthermore, Fuc-induced activation of the AMPK pathway was diminished by the AMPK inhibitor Compound C, and Fuc treatment considerably promoted glucose uptake via Akt activation in an insulin-resistant state. These findings provide a basis for elucidating the mechanism underlying the anti-obesity effect of Fuc, which may, in the future, be considered as a therapeutic compound for treating obesity and related diseases.


Asunto(s)
Proteínas Quinasas Activadas por AMP , Fucosa , Ratones , Animales , Proteínas Quinasas Activadas por AMP/metabolismo , Fucosa/metabolismo , Células 3T3-L1 , Adipocitos , Insulina/metabolismo , Obesidad/tratamiento farmacológico , Obesidad/metabolismo , Lípidos/farmacología , Adipogénesis
2.
Nutrients ; 12(12)2020 Dec 11.
Artículo en Inglés | MEDLINE | ID: mdl-33322300

RESUMEN

Obesity is a global public health problem and a risk factor for several metabolic disorders as well as cancer. In this study, we investigated the effects of L-fucose on lipid metabolism through chronic and acute in vivo experiments in mice. In the chronic test, mice were fed a high-calorie diet (HCD) containing 0.0001%, 0.001%, 0.01%, and 0.1% L-fucose for one month. The L-fucose supplementation inhibited body weight and visceral fat mass gain in HCD-fed mice. The results of the acute test showed that L-fucose increased the ratio of serum high molecular weight adiponectin and enhanced glucose and lipid catabolism. Furthermore, L-fucose also decreased the expression of adipogenic genes (peroxisome proliferator-activated receptor γ and cluster of differentiation 36). In conclusion, this study provides a new approach to combat obesity and the related diseases.


Asunto(s)
Fármacos Antiobesidad/farmacología , Fucosa/farmacología , Monosacáridos/farmacología , Obesidad/tratamiento farmacológico , Phaeophyceae/química , Adipogénesis/efectos de los fármacos , Adiponectina/sangre , Animales , Glucemia/efectos de los fármacos , Dieta Alta en Grasa/efectos adversos , Metabolismo de los Lípidos/efectos de los fármacos , Masculino , Ratones , Ratones Endogámicos C57BL , Ratones Obesos , Obesidad/sangre , Obesidad/etiología , Aumento de Peso/efectos de los fármacos
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