Impacts of thyme and/or garlic oils on growth, immunity, antioxidant and net farm income in Damascus goats.

This study aimed to evaluate the impact of thyme and/or garlic oil administration on growth performance, immunity, antioxidant, biochemical parameters, and net farm income of Damascus goats. Forty weaned Damascus goats were allocated into four groups. The first group was the control without oral administration, while the 2nd (Th), 3rd (Gr), and 4th (ThGr) groups were orally administrated by (2 ml/goat/day) of thyme oil, garlic oil and their mixture (1:1), respectively during the whole experiment period. The final body weight of goats orally administered oil mixture was the heaviest group, it was 10, 4.5 and 3.5% than the control, Th. and Gr. groups, respectively with better feed conversion ratio and high net farm income. Goats of ThGr. group revealed the best immunity, antioxidant and general health condition than the control group with 50% reduction of MDA. Liver (AST, 33% and ALT, 38%) and kidney (creatinine, 88%) functions improved by oils mixtures orally administration compared with the control group. LDL, triglyceride and cholesterol were reduced by 47, 33 and 21% compared with the control group, respectively. Thus, mixture oil administration (thyme and garlic at the ratio of 1:1, 2 ml/goat/day) improved growth (10%), antioxidant status (MDA 50%), liver (AST, 33% and ALT, 38%), kidney function (creatinine, 88%), the FCR (17.4%) and net farm income (21%), of Damascus goats.

Exploring the Mental Health Challenges of Emergency Medicine and Critical Care Professionals: A Comprehensive Review and Meta-Analysis.

Burnout and depression are global problems affecting healthcare providers, especially those working in stressful departments such as emergency departments (EDs) and critical care units (CCUs). However, pooled data analysis comparing healthcare providers operating in the ED and CCU is yet to be conducted. Therefore, this meta-analysis was systematically conducted to investigate and compare the prevalence of burnout and depression among emergency medicine (EM) and critical care medicine (CCM) professionals. We systematically searched for articles related to our research topic using the database search method and manual search method, which involved reviewing the reference lists of articles from electronic databases for additional studies. After screening the literature from the databases using the eligibility criteria, a quality appraisal using the Newcastle-Ottawa scale was performed on the eligible studies. In addition, a meta-analysis using the Review Manager software was performed to investigate the prevalence rates of burnout and depression. A total of 10 studies with 1,353 EM and 1,250 CCM professionals were included for analysis in the present study. The pooled analysis did not establish any considerable differences between EM and CCM healthcare workers on the prevalence of high emotional exhaustion (EE) (odds ratio (OR) = 1.01; 95% confidence interval (CI) = 0.46-2.19; p = 0.98), high depersonalization (OR = 1.16; 95% CI = 0.61-2.21; p = 0.64), low personal accomplishment (PA) (OR = 0.87; 95% CI = 0.67 - 1.12; p = 0.28), and depression (OR = 1.20; 95% CI = 0.74-1.95; p = 0.45). Moreover, pooled data showed no considerable differences in EE scores (mean difference (MD) = -1.07; 95% CI = -4.24-2.09; p = 0.51) and depersonalization scores (MD = -0.31; 95% CI = -1.35-0.73; p = 0.56). However, EM healthcare workers seemed to have considerably lower PA scores than their CCM counterparts (MD = 0.12; 95% CI = 0.08-0.16; p < 0.00001). No considerable difference was recorded in the prevalence of burnout and depression between EM and CCM healthcare workers. However, our findings suggest that EM professionals have lower PA scores than CCM professionals; therefore, more attention should be paid to the mental health of EM professionals to improve their PA.

Silent Type-B Aortic Dissection Accidentally Discovered in a COVID-19-Positive Patient.

Aortic dissection is a critical medical condition that poses a significant threat to life, and if left untreated, it can lead to high mortality and morbidity rates. The risk of various cardiovascular complications, including aortic dissection, is increased in individuals with coronavirus disease 2019 (COVID-19). However, the significance of aortic dissection as a complication in COVID-19 patients is often underestimated. Traditionally, aortic dissection without pain was considered uncommon. However, recent information indicates that symptoms in patients with aortic dissection can be more diverse than previously believed. The classic symptoms of tearing chest, back, or abdominal pain may be absent, making diagnosis challenging. We present the incidental detection of an asymptomatic Stanford type-B aortic dissection during a computed tomography (CT) scan conducted to evaluate COVID-19. The patient was managed through conservative treatment.

Unlocking the Optimal Analgesic Potential: A Systematic Review and Meta-Analysis Comparing Intravenous, Oral, and Rectal Paracetamol in Equivalent Doses.

Paracetamol (acetaminophen) is an extensively used analgesic for acute and chronic pain management. Currently, paracetamol is manufactured for oral, rectal, and intravenous (IV) use. Research has shown varied results on the analgesic properties of IV paracetamol compared to oral and rectal paracetamol; however, research on the same doses of paracetamol is limited. Therefore, this review was constructed to explore the analgesic properties of IV paracetamol compared with oral and rectal paracetamol administered in equivalent doses. A broad and thorough literature search was performed on five electronic databases, including PubMed, ScienceDirect, Medline, Scopus, and Google Scholar. Statistical analysis of all outcomes in our review was then performed using the Review Manager software. Outcomes were categorized as primary (pain relief and time to request rescue analgesia) and secondary (adverse events after analgesia). An extensive quality appraisal was also done using the Review Manager software's Cochrane risk of bias tool. The literature survey yielded 2,945 articles, of which 12 were used for review and analysis. The pooled analysis for patients undergoing surgical procedures showed that IV paracetamol had statistically similar postoperative pain scores at two (mean difference (MD) = -0.14; 95% confidence interval (CI) -0.58-0.29; p = 0.51), 24 (MD = 0.09; 95% CI = -0.02-0.21; p = 0.12), and 48 (MD = 0.04; 95% CI = -0.08-0.16; p = 0.52) hours as oral paracetamol. Similarly, the data on time to rescue analgesia showed no considerable difference between the IV and oral paracetamol groups (MD = -1.58; 95% CI = -5.51-2.35; p = 0.43). On the other hand, the pooled analysis for patients presenting non-surgical acute pain showed no significant difference in the mean pain scores between patients treated with IV and oral paracetamol (MD = -0.35; 95% CI = -2.19-1.48; p = 0.71). Furthermore, a subgroup analysis of analgesia-related adverse events showed that the incidences of vomiting/nausea and pruritus did not differ between patients receiving IV and oral paracetamol (odds ratio (OR) = 0.71; 95% CI = 0.45-1.11; p = 0.13 and OR = 0.48; 95% CI = 0.18-1.29; p = 0.05, respectively). A review of information from two trials comparing equal doses of IV and rectal paracetamol suggested that the postoperative pain scores were statistically similar between the groups. IV paracetamol is not superior to oral or rectal paracetamol administered in equal doses. Therefore, we cannot recommend or refute IV paracetamol as the first-line analgesia for acute and postoperative pain.

Evaluating Rutting Resistance of Rejuvenated Recycled Hot-Mix Asphalt Mixtures Using Different Types of Recycling Agents.

Growing environmental pollution worldwide is mostly caused by the accumulation of different types of liquid and solid wastes. Therefore, policies in developed countries seek to support the concept of waste recycling due to its significant impact on the environmental footprint. Hot-mix asphalt mixtures (HMA) with reclaimed asphalt pavement (RAP) have shown great performance under rutting. However, incorporating a high percentage of RAP (>25%) is a challenging issue due to the increased stiffness of the resulting mixture. The stiffness problem is resolved by employing different types of commercial and noncommercial rejuvenators. In this study, three types of noncommercial rejuvenators (waste cooking oil (WCO), waste engine oil (WEO), and date seed oil (DSO)) were used, in addition to one type of commercial rejuvenator. Three percentages of RAP (20%, 40%, and 60%) were utilized. Mixing proportions for the noncommercial additives were set as 0−10% for mixtures with 20% RAP, 12.5−17.5% for mixtures with 40% RAP, and 17.5−20% for mixtures with 60% RAP. In addition, mixing proportions for the commercial additive were set as 0.5−1.0% for mixtures with 20% RAP, 1.0−1.5% for mixtures with 40% RAP, and 1.5−2.0% for mixtures with 60% RAP. The rutting performance of the generated mixtures was indicated first by using the rutting index (G*/sin δ) for the combined binders and then evaluated using the Hamburg wheel-track test. The results showed that the rejuvenated mixtures with the commercial additive at 20 and 60% RAP performed well compared to the control mixture, whereas the rejuvenated ones at 40% RAP performed well with noncommercial additives in comparison to the control mixture. Furthermore, the optimum percentages for each type of the used additives were obtained, depending on their respective performance, as 10%, 12.5%, and 17.5% of WCO, 10%, 12.5−17.5%, and 17.5% of WEO, <10%, 12.5%, and 17.5% of DSO, and 0.5−1.0%, 1.0%, and 1.5−2.0% of the commercial rejuvenator, corresponding to the three adopted percentages of RAP.

Genetic parameters of production and reproduction traits of Egyptian buffaloes under subtropical conditions.

This research was aimed to investigate the production and reproduction traits and their genetic parameters of Egyptian buffaloes under subtropical environment. Heritability, phenotypic, and genetic parameters were estimated for productive and reproduction traits of first parity This study revealed the averages TMY, 305-dMY, LL, BW, DP, SP, CI, and AFC were 2260, 2150 kg, 271 days, 38.63 kg, 210.50 days, 195.20 days, 586.86 days, and 36.61 months, respectively. The heritability estimates for productive traits of the first lactation were 0.61, 0.52, 0.47, 0.20, and 0.23 for TMY, 305-dMY, LL, DP, and BW, respectively. Heritability estimates for reproductive traits SP, CI, and AFC were 0.07, 0.09, and 0.35, respectively. Genetic correlations of most of the investigated first parity traits were positive, with an exception of DP. The genetic correlation was negative between SP and BW, and between AFC and LL. Phenotypic correlations of the first parity among all investigated traits were positive except between DP and TMY, 305-dMY, LL, BW, and AFC. High and moderate heritability estimates indicated that the opportunity of genetic upgrading of these parameters could be achieved owing to sire selection. Selection for high milk yield will be associated with genetic improvement in lactation period and birth weight.

Growth, carcass parameters, biochemical and oxidative stress indices, and meat traits of duck breeds under different stocking densities.

This investigation was aimed to inspect if there is an influence of various stocking density on growth, carcass parameters, blood indices, and meat traits of Muscovy and Mallard ducks. One hundred twenty-six 1-day-old of each Muscovy and Mallard ducks were randomly allocated into three experimental groups with different stocking density. Group one (SD1) was 5 ducks/m2, while group 2 (SD2) was 7 ducks/m2 and group 3 (SD3) was 9 ducks/m2. The growth, carcass parameters, meat quality, blood indices were calculated. Body weight of SD1 was 18 and 4.5% heavier than SD2, while, it was 29.5 and 12% heavier than SD3 of Muscovy and Mallard duck breeds, respectively. SD3 possessed the highest levels of, H/L, ALT, AST, LDL, VLDL, and MDA with the lowest levels of lymphocyte, SOD,GSH, GPX, C3, total antioxidant capacity and IGG of both ducks' breeds. The carcass weight decreased by 40 and 15% from SD1 to SD3 in Muscovy and mallard ducks, respectively. The dressing % was highest at SD1 (84 and 83%) when compared with SD3(71and80%) of Muscovy and Mallard ducks, respectively. Cooking loss was 20 and 16% greater in group three when compared with group one in Muscovy and Mallard ducks, respectively. In conclusion ducks raised in low SD possessed the best performance with better welfare.

Productive Performance and Blood Biochemical Parameters of Dairy Cows Fed Different Levels of High-Protein Concentrate.

This study investigated the productive traits and some blood biochemical parameters of high-yielding Ayrshire dairy cows fed at different levels of Agro-Matic@LLC NGO, Russia (Agro-Matic (AM)) protein concentrate. A total of 45 high-yielding Ayrshire cows were selected and divided into three groups, each 15. The control group (0AM) fed the basal ration, while group two (1AM) and group three (2AM) fed a basal ration by replacing sunflower cake with different levels of AM (1 and 1.5 kg/head/day), respectively. Milk and blood samples were collected. The current results revealed that the ratio of rumen undegradable protein to rumen degradable protein during the period of lactation was significantly higher in the 1AM and 2AM compared with 0AM and represented (55.04, 62.14, and 41.73%), respectively. The 1AM had a beneficial effect on the digestibility of crude protein. Daily and whole fat-corrected milk (FCM 4 %) was significantly increased by 3 kg/day and 987 kg/entire lactation in 2AM when compared with 0AM, respectively. Blood total protein was significantly higher in the 1AM group (86.9 vs. 77.8 g/l) than the 0AM, while AM decreased urea concentration. Consequently, the inclusions of AM protein concentrate have a positive impact on increasing milk production and optimizing the rations in terms of the amount of non-digestible protein and the economic efficiency of milk production.

Early nutrition programming with Astragalus membranaceus polysaccharide: its effect on growth, carcasses, immunity, antioxidants, lipid profile and liver and kidney functions in broiler chickens.

This study aimed to determine the influence of in ovo injection of Astragalus membranaceus polysaccharide on growth, feed consumption, feed conversion ratio, carcasses, hematology, and blood metabolites in Cobb 500 chicks. At the 7th day of incubation, a total of 250 eggs were randomly divided into five groups with 5 replications of 10 eggs of each: negative control (normal eggs), positive control (0.5 mL saline), 1.5 mg Astragalus membranaceus, 3.0 mg Astragalus membranaceus, and 4.5 mg in ovo Astragalus membranaceus injection. Live body weight and gain were not significantly (linear and quadratic) affected by in ovo injection of Astragalus membranaceus. Kidney and liver functions were influenced by in ovo injection of Astragalus membranaceus polysaccharides in broiler chickens. Antioxidant enzymes were quadratically increased with Astragalus membranaceus polysaccharides, and the highest values achieved with 4.5 mg. The MDA concentration was linearly and quadratically decreased with in ovo injection of Astragalus membranaceus polysaccharides when compared to negative control. The highest values of IgG and IgM were achieved with 1.5 mg Astragalus membranaceus polysaccharides when compared to all other groups. In conclusion, our results indicate that in ovo injection of Astragalus membranaceus polysaccharides 1.5-4.5 mg in broiler eggs significantly improved serum ALT, AST, AP, creatinine enzymes, antioxidant activity, and immune function.

Reproductive Performance and Culling Rate of Purebred Holstein Cows and Their Crosses With Fleckvieh and Brown Swiss Cows Under Subtropical Conditions.

This study aimed to elucidate the reproductive performance of purebred Holstein (HO) cows with their crosses with Fleckvieh (FV) and Brown Swiss (BS) cows under subtropical conditions. A total of 677 cows [487 HO, 104 HO × FV (HFV); 50% FV and 50% HO and 86 HO × BS (HB); 50% BS and 50% HO] were enrolled in this study. Pure HO cows had significantly greater service per conception (S/C; 3.69), days open (147.9 days), and calving interval (449.6 days), than the HFV (2.89, 116.7, and 407.4 days, respectively) and HB (3.07, 134.3, and 434.2 days, respectively) crossbred cows. At day 28, the conception percentage was significantly greater among HFV crossbred cows vs. pure HO cows [crude odds ratios (COR) = 2.16], but embryonic loss, abortion percentage, calving difficulty, and retained placenta percentage were similar (p > 0.05) among pure HO cows and their crosses. HFV crossbreds had significantly lower incidence of endometritis (COR = 0.70, p = 0.035), mastitis (COR = 0.69, p = 0.015), and ketosis (COR = 0.53, p = 0.004) vs. other cows. HB and pure HO cows had a similar incidence of mastitis, lameness, and ketosis (COR = 0.76, 0.75, and 0.81; p = 0.223, 0.468, and 0.492, respectively). HFV crossbred cows had a lower risk of culling rate than HB crossbred cows. In summary, HFV cows demonstrated the best reproductive performance in terms of S/C, days open, calving interval, conception at 28 days, mastitis percentage, ketosis percentage, and endometritis.

Potential impact of stocking density on growth, carcass traits, indicators of biochemical and oxidative stress and meat quality of different broiler breeds.

The aim of the current study to investigate the potential impact of different stocking densities on growth performance, carcass traits, indicators of biochemical and oxidative stress and meat quality of Arbor Acres and Ross-308 broiler breeds to recommend the better stocking density with low production cost simultaneously with high quality. A total of 312 one-day old of each Arbor Acres broiler and Ross-308 were randomly classified into 3 experimental groups with different stocking density, each of 6 replicates. The first group (SD1) was 14 birds/m2 (28 kg/m2), while the second group (SD2) was 18 birds/m2 (36 kg/m2) and the third group (SD3) was 20 birds/m2 (40 kg/m2). The growth performance, carcass traits, meat quality hematological and biochemical parameters were measured. SD3 group possessed the lowest body weight. Alanine transaminase in Arbor Acres was 15 and 14% higher in SD3 when compared with SD1 and SD2, respectively. While, was 21 and 20% of Ross-308, respectively. SD3 revealed the highest values of cholesterol, TG, MDA, and LDL of both breeds when compared with SD1 and SD2, with the lowest levels of HDL, GPX, and IGG. Birds of SD3 was the nastiest carcass weight 873 (P = 0.000) and 1,411.60 g (P = 0.000); dressing percentage 63.07 (P = 0.000) and 75.83% (P = 0.000); breast weight 513.10 g (P = 0.000) and 885.50g (P = 0.000); thigh weight 359.90 g (P = 0.000) and 526.08 g (P = 0.000) when compared with SD1 and SD2 of Arbor Acres and Ross-308, respectively. The dressing % of SD1 and SD2 was approximately 19% better than that of SD3 of Arbor Acres, while it was 4% of Ross-308. The cooking loss and drip loss of breast and thigh muscles were higher in SD3 of both breeds. Moreover, SD3 possessed the highest bacterial count. In conclusion birds reared in medium stocking density revealed better performance and welfare than high density but similar to low density. Therefore, from the economic point, medium density was the best.

Growth, Hemato-Biochemical Parameters, Body Composition, and Myostatin Gene Expression of Clarias gariepinus Fed by Replacing Fishmeal with Plant Protein.

In this study, we evaluated the consequences of replacement of fishmeal with plant protein sources (soybean and sunflower meal) on fish growth parameters, haemato-biochemical factors, body composition, and myostatin gene expression of Clarias gariepinus. A total of 150 C. gariepinus were organized in glass aquaria into five investigational groups, with each group in triplicate (30 fish/group; 10 fish/replicate). Group 1 was fed a control diet (15% fishmeal). The other groups were fed diets where fishmeal was replaced gradually with plant protein, with 10% fishmeal in the second group (D1), 7.5% fishmeal in the third group (D2), 5% fishmeal in the fourth group (D3), and 0% fishmeal in the fifth group (D4). There were no significant differences regarding growth performances and body composition among the groups, except that the feed conversion ratio was improved in D4. The different diet types did not affect hematologic parameters and blood indices. Serum growth hormone and amylase levels also revealed no significant (p = 0.09 and 0.55, respectively) differences among the groups, while serum lipase levels decreased significantly (p = 0.000) due to partial (D2) or complete (D4) substitution of fishmeal with plant protein. The replacement of fishmeal had no effects on liver (p = 0.51) and kidney functions (p = 0.34). However, D4 showed the best profit and economic efficiency compared to the other groups. Altogether, we concluded that substitution of fishmeal with plant protein sources is economically beneficial and may be without any adverse effects on growth parameters, body composition, or hematologic and biochemical parameters, but with the addition of synthetic amino acids.

Immunological Responses and the Antioxidant Status in African Catfish (Clarias gariepinus) Following Replacement of Dietary Fish Meal with Plant Protein.

African catfish (Clarias gariepinus) were subjected to a 30-day feeding trial to determine the appropriateness of using plant protein (PP) (soybean and sunflower meal) as a fishmeal (FM) replacement in the diet and its effects on immune status, antioxidant activity, pituitary adenylate cyclase-activating polypeptide (PACAP) gene expression, and disease resistance. A total of 150 C. gariepinus (51.01 ± 0.34 g) were randomly distributed among five groups in triplicate. Five experimental diets were formulated to replace 0 (control), 33.5, 50, 66.5, and 100% FM with soybean and sunflower meal to form the experimental diets (R0, R33.5, R50, R66.5, and R100, respectively). After 30 days, the diet containing PP for FM had no significant impact on total, and differential leukocyte counts determined at the end of the feeding period. The total globulin concentration showed significantly greater differences in the following order R0 > R33.5 > R50 > R66.5 > R100. The R0 group had the highest concentration of serum γ-globulin, while R100 had the lowest concentration. The antioxidant status complements 3 (C3), lysozyme activity (LYZ), and antiprotease activity were not significantly different between R0, R33.5, and R50 groups, while they were significantly lower in R100. The serum nitric oxide activity (NO) exhibited significantly greater differences in the following order R0 > R33.5 > R50 > R66.5 > R100. PACAP was significantly higher in the R33.5 group. The highest cumulative mortality caused by Aeromonas sobria was recorded in the R100 group (60%) and the lowest in the R0 group (30%). In conclusion, the results indicate that the immunological responses and antioxidant status of C. gariepinus were not affected when they consumed a diet with FM replaced by up to 50% with PP (SBM and SFM) with methionine and lysine supplementation, but total globulin, NO, and cumulative mortality were impaired with a diet containing a 100% FM replacement.

Principal component analysis of breeding values for birth weight milk and reproductive traits of the Egyptian buffalo.

This study was conducted to estimate the genetic parameters and breeding values for birth weight (BW) and reproductive and milk traits of the Egyptian buffalo. Moreover, the relationship among the estimated breeding values was analyzed using the principal component analysis, and selection index was constructed to improve performance. A total of 65,734 records of 2426 buffalo cows calved from 1980 to 2018 were collected from five buffalo experimental herds to estimate the genetic parameters and breeding values and then standardized for use in the principal component analysis with covariance matrix. The estimated heritability values were low for BW, total milk yield (TMY), gestation length (GL), days open (DO), calving interval (CI), calving ease (CE), and age at first calving (AFC), but they were moderate for lactation period (LP). The repeatability estimates were very low for DO and CI but were low for BW, GL, and CE, whereas they were moderate for TMY and LP. Of eight principal components (PCs), four PCs had > 1 eigenvalues, and the total variance explained was 70.37%. The variances explained for PC1, PC2, PC3, and PC4 were 25.71%, 18.20%, 13.28%, and 13.18%, respectively. The standardized estimated breeding values of CI and DO, TMY and LP, GL and CE, and BW and AFC correlated with PC1 (0.915 and 0.925), PC2 (0.760 and 0.758), PC3 (- 0.622 and 0.567), and PC4 (0.710 and 0.438), respectively. These results suggest that BW and reproduction traits would respond slowly to selection, whereas production traits would respond faster, and the uses of PCs depend primarily on the selection purpose that could be used in the genetic improvement programs of the Egyptian buffalo instead of the traditional selection index.

Experimental data on compressive strength and ultrasonic pulse velocity properties of sustainable mortar made with high content of GGBFS and CKD combinations.

The development in the construction sector and population growth requires an increase in the consumption of construction materials, mainly concrete. Cement is the binder in concrete, so increasing cement production will increase the energy consumed, as well as in the emission of carbon dioxide. This harmful effect of the environment led to the search for alternative materials for cement, as the waste or by-products of other industries is a promising solution in this case. Among these common materials are ground granulated blast furnace slag (GGBS) and cement kiln dust (CKD). This dataset describes the compressive strength and ultrasonic pulse velocity of mortar consisted of high content of GGBS and CKD combinations as a partial substitute for cement (up to 80%) at the ages of 1, 2, 3, 7, 14, 21, 28, 56, 90 and 550 days. This dataset can help the researchers to understand the behaviour of GGBS and CKD in high replacement levels for cement during early (1 day) and later ages (550 days). According to this understanding, the authors believe that the data available here can be used to produce more environmentally friendly mortar or concrete mixtures by significantly reducing the amount of cement used by replacing it with waste or by-products of other industries.

Lessons Learned from Large-Scale, First-Tier Clinical Exome Sequencing in a Highly Consanguineous Population.

We report the results of clinical exome sequencing (CES) on >2,200 previously unpublished Saudi families as a first-tier test. The predominance of autosomal-recessive causes allowed us to make several key observations. We highlight 155 genes that we propose to be recessive, disease-related candidates. We report additional mutational events in 64 previously reported candidates (40 recessive), and these events support their candidacy. We report recessive forms of genes that were previously associated only with dominant disorders and that have phenotypes ranging from consistent with to conspicuously distinct from the known dominant phenotypes. We also report homozygous loss-of-function events that can inform the genetics of complex diseases. We were also able to deduce the likely causal variant in most couples who presented after the loss of one or more children, but we lack samples from those children. Although a similar pattern of mostly recessive causes was observed in the prenatal setting, the higher proportion of loss-of-function events in these cases was notable. The allelic series presented by the wealth of recessive variants greatly expanded the phenotypic expression of the respective genes. We also make important observations about dominant disorders; these observations include the pattern of de novo variants, the identification of 74 candidate dominant, disease-related genes, and the potential confirmation of 21 previously reported candidates. Finally, we describe the influence of a predominantly autosomal-recessive landscape on the clinical utility of rapid sequencing (Flash Exome). Our cohort's genotypic and phenotypic data represent a unique resource that can contribute to improved variant interpretation through data sharing.

Correction to: Vascular suture line wrapping for aortoiliac anastomoses following open surgical repair of infrarenal Behçet's aortoiliac aneurysms.

Following the publication of this article [1], the authors informed us of a typographical error in the spelling of "ePET-Dacron®" in the Background section. The sentence to be corrected is the following: "While anastomosing graft to host artery, vascular suture lines has been reinforced with expanded polyethylene terephthalate (ePTE - Dacron®), polytetrafluoroethylene (ePTFE), omentum, an autogenous vein, or mesh to wrap the vascular anastomoses."

Vascular suture line wrapping for Aortoiliac anastomoses following open surgical repair of Infrarenal Behçet's Aortoiliac aneurysms.

BACKGROUND: This study was conducted to evaluate our local experiences of adjunctive mechanical prosthetic wrapping for aortoiliac vascular anastomoses as a prophylactic measure following surgical repair of Behçet's aortoiliac aneurysms. The goal of prosthetic wrapping to reinforce the vascular anastomoses by mechanical protection to reduce the bleeding complications, and consequently pseudoaneurysm formation. This was aided by the administration of pre- and postoperative immunosuppressive therapy as an adjuvant treatment. METHODS: A seven-year retrospective study was conducted between January 2006 and December 2012, retrieving data of patients with Behçet's aortoiliac aneurysms. All patients underwent open surgical repair using a heparin-bonded synthetic Dacron® graft. Data for all patients were retrieved and analyzed for diagnostic procedures, graft selection, as well as, different methods of surgical repair. Graft-related complications such as anastomotic pseudoaneurysms, occlusion, and thrombosis were also reported. RESULTS: Sixteen patients were recruited in this study. There were  11 (69%) males and 5 (31%) females with the male to female ratio 2:1. The patients' age ranged between 25 and 47 years with the mean of 36.4 ± 7.3. All Behçet's aortic/aortoiliac aneurysms were repaired by the application of heparin-bonded Dacron® tube and bifurcated grafts. The anastomotic wrapping technique was performed for both the proximal and the distal vascular anastomoses. The technical success of aortoiliac aneurysm and wrapping techniques was achieved in 100% of patients. All patients were given pre- and postoperative systemic immunosuppressive therapy. No graft-related complications were reported except for only one anastomotic pseudoaneurysm that developed at one of the right iliac anastomoses, that developed within 24 months after follow up. CONCLUSIONS: Mechanical prosthetic wrapping for vascular anastomoses in patients with Behçet's aortic/aortoiliac aneurysms is a feasible, simple, and reliable technique with low morbidity and mortality. It was performed as a prophylactic measure to avoid the development of postoperative anastomotic pseudoaneurysms. It must be performed for all patients with Behçet's arterial aneurysms whenever possible. Furthermore, the supplemental administration of pre- and postoperative systemic immunosuppressive therapy should be considered as an important factor for the prophylaxis and prevention of anastomotic pseudoaneurysms and other graft-related complications.

Does light intensity affect the behavior, welfare, performance, meat quality, amino acid profile, and egg quality of Japanese quails?

The current study aimed to explore the impact of different light intensities on behavior, welfare, performance, meat quality, amino acid content, and egg quality of Japanese quails. A total of 600 1-day-old Japanese quail chicks were used (300/batch). Chicks were homogeneously classified into 3 groups (each of 100); low (10 lux), moderate (50 lux). and high light intensity (250 lux) groups. There was a significant effect (P < 0.05) of light intensity in most of the Japanese quails' behaviors. Quails reared on low light intensity showed the lowest behavior of feeding, drinking, flying, and feather picking, while the highest behaviors were preening, dust bathing, leg and wing stretching, and body shaking when compared with the other groups. Moreover, they had the better welfare (lowest H/L ratio and corticosterone levels). Quails of low light intensity groups possessed the heaviest body weight (145.17 g, P = 0.000) with the lowest daily feed intake (14.17 g) but with the best feed conversion ratio (3.39%, P = 0.000). Moreover, they had the heaviest slaughter (132.47 g, P = 0.000) and carcass weight (109.29 g, P = 0.000) and carcass yield (75.37%, P = 0.000) when compared with the others groups. Muscles of quails (both of pectoral and thigh) kept under low light intensity revealed the highest percentage of lightness, yellowness, and water-holding capacity with the lowest percentage of cooking loss, thiobarbituric acid reactive substances, and some amino acids. They also had the heaviest egg weight (11.24 g, P = 0.000) with the best external and internal egg-quality grades (P < 0.05). Consequently, low light intensity is suggested for improving quail's welfare, performance, and reproduction, while the high light intensity had a detrimental effect on both welfare and performance.