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2.
Gan To Kagaku Ryoho ; 43(3): 373-5, 2016 Mar.
Artículo en Japonés | MEDLINE | ID: mdl-27067859

RESUMEN

The recommended regimen for S-1 internal use is 4 weeks of daily medication and 2 weeks of drug holiday. However, we experience many cases where changing the regimen is ineffective because of adverse events. This time, we report a favorable case of alternate-day treatment with S-1 in an elderly patient with multiple lung metastases of colon cancer. An 84-year-old woman, performance status 2, was diagnosed as having colon cancer and multiple lung metastases. After operation of the colon, she received chemotherapy with the S-1 alternate-day treatment. The lung metastases decreased remarkably, and she was able to continue the treatment without significant adverse events. She has been receiving the treatment without progression for more than 18 months now. The alternate-day treatment with S-1 is reported as a cure with anticancer efficacy and few adverse events. This treatment seems to be a useful chemotherapy for elderly patients with colon cancer.


Asunto(s)
Antimetabolitos Antineoplásicos/uso terapéutico , Neoplasias del Colon/tratamiento farmacológico , Neoplasias Pulmonares/tratamiento farmacológico , Ácido Oxónico/uso terapéutico , Tegafur/uso terapéutico , Anciano de 80 o más Años , Antimetabolitos Antineoplásicos/administración & dosificación , Quimioterapia Adyuvante , Neoplasias del Colon/patología , Neoplasias del Colon/cirugía , Combinación de Medicamentos , Femenino , Humanos , Neoplasias Pulmonares/secundario , Ácido Oxónico/administración & dosificación , Tegafur/administración & dosificación , Resultado del Tratamiento
3.
Gan To Kagaku Ryoho ; 43(1): 103-6, 2016 Jan.
Artículo en Japonés | MEDLINE | ID: mdl-26809535

RESUMEN

A 42-year-old woman visited our hospital with high fever and general malaise. A CT examination revealed that she had carcinoma of the left breast with axillary lymph node metastases and multiple bone metastases. A blood test showed anemia, thrombopenia and the existence of blast-like cells. Adenocarcinoma cells were detected in a bone marrow aspiration specimen, and the patient was diagnosed with disseminated carcinomatosis of the bone marrow. Systemic chemotherapy with paclitaxel plus bevacizumab was initiated while a blood transfusion was performed. Her symptoms improved, and the blood test results normalized. Disseminated carcinomatosis of the bone marrow is reported to have a poor prognosis, but paclitaxel plus bevacizumab is a possible effective chemotherapy.


Asunto(s)
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Neoplasias de la Médula Ósea/tratamiento farmacológico , Neoplasias de la Mama/tratamiento farmacológico , Adulto , Bevacizumab/administración & dosificación , Neoplasias de la Médula Ósea/secundario , Neoplasias de la Mama/patología , Femenino , Humanos , Paclitaxel/administración & dosificación , Resultado del Tratamiento
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