Limitations associated with thermoregulation and cardiovascular research assessing laborers performing work in the heat.

PURPOSE: To quantify the current literature and limitations associated with research examining thermoregulatory and cardiovascular strain in laborers working in the heat. METHODS: PubMed, SCOPUS, and SPORTDiscus were searched for terms related to the cardiovascular system, heat stress, and physical work. Qualifying studies included adult participants (18-65 years old), a labor-intensive environment or exercise protocol simulating a labor environment, a minimum duration of 120 min of physical work, and environmental heat stress (ambient temperature ≥26.0°C and ≥30% relative humidity). Studies included at least one of the following outcomes: pre- and peak physical work, core temperature, heart rate (HR), systolic blood pressure, diastolic blood pressure, HR variability, and rate pressure product. RESULTS: Twenty-one out of 1559 potential studies qualified from our search. There was a total of 598 participants (mean = 28 ± 50 participants per study, range = 4-238 participants per study), which included 51 females (8.5%) and 547 males (91.5%). Of the participants, 3.8% had cardiovascular risk factors (diabetes: n = 10; hypertension: n = 13) and 96.2% were characterized as "healthy". Fifty-seven percent of the included studies were performed in a laboratory setting. CONCLUSIONS: Studies were predominantly in men (91.5%), laboratory settings (57%), and "healthy" individuals (96.2%). To advance equity in protection against occupational heat stress and better inform future heat safety recommendations to protect all workers, future studies must focus on addressing these limitations. Employers, supervisors, and other safety stakeholders should consider these limitations while implementing current heat safety recommendations.

The effect of heat mitigation strategies on thermoregulation and productivity during simulated occupational work in the heat in physically active young men.

Purpose: To investigate heat stress mitigation strategies on productivity and thermoregulatory responses during simulated occupational work in the heat. Methods: Thirteen physically active men (age, 25 ± 4 years; body mass,77.8 ± 14.7 kg; VO2peak, 44.5 ± 9.2 ml·kg-1·min-1) completed five randomized-controlled trials in a hot environment (40°C, 40% relative humidity). Each trial was 4.5 h in duration to simulate an outdoor occupational shift. Thermoregulatory responses (heart rate, HR; rectal temperature, Trec; mean skin temperature, Tsk), perceptual responses (rating of perceived exertion, RPE; thermal sensation; thermal comfort; fatigue) and productivity outcomes (box lifting repetitions, time to exhaustion) were examined in the following heat mitigation strategy interventions: (1) simulated solar radiation with limited fluid intake [SUN]; (2) simulated solar radiation with no fluid restrictions [SUN + H2O]; (3) shade (no simulated solar radiation during trial) with no fluid restrictions [SHADE + H2O]; (4) shade and cooling towels during rest breaks with no fluid restrictions [COOL + H2O]; and (5) shade with cooling towels, cooling vest during activity with no fluid restrictions [COOL + VEST + H2O]. Results: [COOL + VEST + H2O] had lower Trec compared to [SUN] [p = 0.004, effect size(ES) = 1.48], [SUN + H2O] (p < 0.001, ES = -1.87), and [SHADE + H2O] (p = 0.001, ES = 1.62). Average Tsk was lower during the treadmill and box lifting activities in the [COOL + VEST + H2O] compared to [SUN] (p < 0.001, ES = 7.92), [SUN + H2O] (p < 0.001,7.96), [SHADE + H2O] (p < 0.001), and [COOL + H2O] (p < 0.001, ES = 3.01). There were performance differences during the [COOL + VEST + H2O] (p = 0.033) and [COOL + H2O] (p = 0.023) conditions compared to [SUN] during phases of the experimental trial, however, there were no differences in total box lifting repetitions between trials (p > 0.05). Conclusion: Our results suggest that during a simulated occupational shift in a laboratory setting, additional heat mitigation strategies ([COOL + VEST + H2O] and [COOL + H2O]) reduced physiological strain and improved box lifting performance to a greater degree than [SUN]. These differences may have been attributed to a larger core to skin temperature gradient or reduction in fatigue, thermal sensation, and RPE during [COOL + H2O] and [COOL + VEST + H2O]. These data suggest that body cooling, hydration, and "shade" (removal of simulated radiant heat) as heat stress mitigation strategies should be considered as it reduces physiological strain while producing no additional harm.

Rape Myth Acceptance and General Self-Efficacy: Gender, Race, and Ethnic Differences of Knowing a Sexual Assault Victim among University Students.

Knowing a sexual assault victim and general self-efficacy (GSE) were examined as predictors of rape myth acceptance (RMA) among university students. Where knowing a sexual assault victim was associated with greater rejection of rape myths among female students, most notably White females, a null effect occurred on male students, except for Black males whose RMA increased. Higher self-efficacy predicted the overall rejection of rape myths differently among identity intersections, most prominently with victim blaming. Knowing a sexual assault victim moderated GSE and RMA for male students and Latinos. These findings offer practical and critical implications as universities grow in diversity.

Effects of humeral intraosseous epinephrine in a pediatric hypovolemic cardiac arrest porcine model.

BACKGROUND: Aims of the study were to determine the effects of humerus intraosseous (HIO) versus intravenous (IV) administration of epinephrine in a hypovolemic, pediatric pig model. We compared concentration maximum (Cmax), time to maximum concentration (Tmax), mean concentration (MC) over time and return of spontaneous circulation (ROSC). METHODS: Pediatric pig were randomly assigned to each group (HIO (n=7); IV (n=7); cardiopulmonary resuscitation (CPR)+defibrillation (defib) (n=7) and CPR-only group (n=5)). The pig were anesthetized; 35% of the blood volume was exsanguinated. pigs were in arrest for 2 min, and then CPR was performed for 2 min. Epinephrine 0.01 mg/kg was administered 4 min postarrest by either route. Samples were collected over 5 min. After sample collection, epinephrine was administered every 4 min or until ROSC. The Cmax and MC were analyzed using high-performance liquid chromatography. Defibrillation began at 3 min postarrest and administered every 2 min or until ROSC or endpoint at 20 min after initiation of CPR. RESULTS: Analysis indicated that the Cmax was significantly higher in the IV versus HIO group (p=0.001). Tmax was shorter in the IV group but was not significantly different (p=0.789). The MC was significantly greater in the IV versus HIO groups at 90 and 120 s (p<0.05). The IV versus HIO had a significantly higher MC (p=0.001). χ2 indicated the IV group (5 out of 7) had significantly higher rate of ROSC than the HIO group (1 out of 7) (p=0.031). One subject in the CPR+defib and no subjects in the CPR-only groups achieved ROSC. DISCUSSION: Based on the results of our study, the IV route is more effective than the HIO route.

National Comparisons of Rape Myth Acceptance Predictors Between Nonathletes and Athletes From Multi-Institutional Settings.

Athletes are cited as common perpetrators of sexual victimization and are at greater risk of becoming offenders compared with nonathletes. Demographic, lifestyle, and social characteristics of 624 nonathletes and 101 athletes from 21 U.S. Division I postsecondary educational institutions were assessed, with the updated Illinois Rape Myth Acceptance scale gauging endorsement of rape myths. Results indicate that athletes and nonathletes were similar in the degree of rape myth acceptance, with athletes reporting stronger agreement with rape myths than nonathletes did. Predictors of rape myth acceptance among nonathletes are multidimensional. In contrast, nondemographic characteristics like Greek membership, the number of alcoholic beverages consumed, and knowing a sexual assault victim predict rape myth acceptance for athletes, with gender not predicting rape myth acceptance nor different between genders of athletes. Policy implications and future research are discussed.

Obturación en endodoncia: nuevos sistemas de obturación: revisión de literatura / Endodontics filling: new filling systems: review of the literature

El objetivo de esta revisión fue de recopilar la información correspondiente a las bases y criterios para la obturación del sistema de conductos radiculares así como de los nuevos sistemas de obturación disponibles a nivel mundial, evaluando sus características, ventajas y desventajas.

The aim of this review was to gather information on the basis and criteria for filling the root canal system and the new sealing systems available worldwide, evaluating their characteristics, advantages and disadvantages.

Enabling collaborative research using the Biomedical Informatics Research Network (BIRN).

OBJECTIVE: As biomedical technology becomes increasingly sophisticated, researchers can probe ever more subtle effects with the added requirement that the investigation of small effects often requires the acquisition of large amounts of data. In biomedicine, these data are often acquired at, and later shared between, multiple sites. There are both technological and sociological hurdles to be overcome for data to be passed between researchers and later made accessible to the larger scientific community. The goal of the Biomedical Informatics Research Network (BIRN) is to address the challenges inherent in biomedical data sharing. MATERIALS AND METHODS: BIRN tools are grouped into 'capabilities' and are available in the areas of data management, data security, information integration, and knowledge engineering. BIRN has a user-driven focus and employs a layered architectural approach that promotes reuse of infrastructure. BIRN tools are designed to be modular and therefore can work with pre-existing tools. BIRN users can choose the capabilities most useful for their application, while not having to ensure that their project conforms to a monolithic architecture. RESULTS: BIRN has implemented a new software-based data-sharing infrastructure that has been put to use in many different domains within biomedicine. BIRN is actively involved in outreach to the broader biomedical community to form working partnerships. CONCLUSION: BIRN's mission is to provide capabilities and services related to data sharing to the biomedical research community. It does this by forming partnerships and solving specific, user-driven problems whose solutions are then available for use by other groups.

Comparación microscópica de la adaptación del cono maestro de gutapercha con conicidades 2 por ciento y 6 por ciento / Microscopic comparison of the adaptation of master gutta-percha 2 per cent and 6 per cent tapered cones

El propósito de este estudio, in vitro, fue analizar y comparar microscópicamente la adaptación de los conos de gutapercha, a nivel del tercio coronal, medio y apical, al ser obturados con la técnica de condensación lateral empleando conos maestros de gutapercha con conicidades .06 y .02, en dientes preparados biomecánicamente con técnica híbrida utilizando los sistemas rotatorios PROTAPER y PROFILE. Se obturaron treinta premolares unirradiculares, 15 dientes por grupo, adicionalmente se registró el número de conos accesorios requeridos en cada obturación. Se fotografiaron los cortes transversales a través de un estereomicroscopio, para realizar un análisis métrico obteniendo áreas proporcionales de los espacios, en el programa AutoCad 2005. Los resultados se analizaron con la prueba t de Student: no se encontró diferencia estadísticamente significativa al comparar la adaptación de los conos de gutapercha entre el grupo I (conicidad, 02) y grupo II (conicidad, 06) (p mayor 0,05); adicionalmente se observó el empleo de menor cantidad de conos accesorios al obturar con un cono maestro con conicidad , 06 considerándose como un hallazgo.