RESUMEN
Comparative data are presented illustrating efficiency of the treatment of patients with chronic viral hepatitis by standard therapeutic methods and basal therapy combined with ozone therapy. Patients treated with the use of ozone exhibited better biochemical, virological, and functional characteristics compared with their counterparts managed by standard methods. The results of the study suggest a higher efficiency of combined therapy and reduced risk of development of cholelithiasis.
Asunto(s)
Hepatitis B Crónica/tratamiento farmacológico , Hepatitis C Crónica/tratamiento farmacológico , Oxidantes Fotoquímicos/uso terapéutico , Ozono/uso terapéutico , Adulto , Colelitiasis/tratamiento farmacológico , Colelitiasis/etiología , Femenino , Hepatitis B Crónica/complicaciones , Hepatitis C Crónica/complicaciones , Humanos , Masculino , Estudios Retrospectivos , Factores de RiesgoRESUMEN
Changes of physical properties and colloidal properties and microscopic picture of gall and liver bladder are detected in patients with virus hepatic B and C. A big number of chrystal elements (cholesterol chrystals gall acids, calcium belirubinates, microlytes) as well as cyllindic epithelium cells are revealed. The revealed changes degree isn't conncted with virus hepatitis ethyology, but proportionate to intensity of expressive changes in liver parenchyma.
Asunto(s)
Bilis/química , Vesícula Biliar/patología , Hepatitis B/patología , Hepatitis C/patología , Hígado/patología , Adulto , Bilis/metabolismo , Vesícula Biliar/metabolismo , Hepatitis B/metabolismo , Hepatitis C/metabolismo , Humanos , Hígado/metabolismo , Hígado/virología , MasculinoRESUMEN
AIM: to study the biochemical composition of cystic and hepatic bile in patients with different forms of viral hepatitis. SUBJECTS AND METHODS: Four hundred and fifty-seven patients with different forms of viral hepatitis were examined. The concentration and debit of cholic acid (CA), total cholesterol, total bilirubin, phospholipids, calcium, and C-reactive protein were determined by a bile biochemical study. Cholate-cholesterol and phospholipid-cholesterol ratios were simultaneously calculated for each bile portion. RESULTS: CA levels and cholate-cholesterol ratios were significantly decreased in all patients with viral hepatitis. The findings suggest that duodenal digestion was impaired, CA secretion was lowered and the majority of patients with viral hepatitis had biliary insufficiency. CONCLUSION: Stepwise chromatic duodenal intubation should be used, by making a biochemical study of bile portions and calculating the total debit of bile components secreted per hour after administration of a stimulus, in order to make a complex diagnosis of exocrine function of the liver in patients with viral hepatitis.
Asunto(s)
Bilis/química , Vesícula Biliar/fisiopatología , Hepatitis Crónica/fisiopatología , Hígado/fisiopatología , Adulto , Colatos/análisis , Colesterol/análisis , Ácido Cólico/análisis , Femenino , Vesícula Biliar/metabolismo , Humanos , Hígado/metabolismo , Masculino , Adulto JovenRESUMEN
Patients with viral hepatitis have disturbances of biliary tract motor function with the tendency to hypertonus of Oddi's sphincter, changes of physic-colloid properties of bile with increase in density of gall and hepatic bile, pH shift to acid side, microlites formation, disorders in biochemical composition of bile. More than 80% patients have biliar insufficiency. According to our data, with the purpose to correct of disturbances of hepatic exocrine function in patients with viral hepatitis and to prevent stone formation, it is reasonable to use together with antiviral therapy also intravenous injection of ozonated physiological solution and preparations of ursodeoxycholic acid.