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Curr Biol ; 34(15): 3550-3563.e8, 2024 Aug 05.
Artículo en Inglés | MEDLINE | ID: mdl-39043188

RESUMEN

It is unknown why roses are terpene-rich, what the terpene biosynthetic pathways in roses are, and why only a few rose species produce the major components of rose essential oil. Here, we assembled two high-quality chromosome-level genomes for Rosa rugosa and Rosa multiflora. We also re-sequenced 132 individuals from the F1 progeny of Rosa chinensis and Rosa wichuraiana and 36 of their related species. Comparative genomics revealed that expansions of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR) and terpene synthases (TPSs) gene families led to the enrichment of terpenes in rose scent components. We constructed a terpene biosynthesis network and discovered a TPS-independent citronellol biosynthetic pathway in roses through gene functional identification, genome-wide association studies (GWASs), and multi-omic analysis. Heterologous co-expression of rose citronellol biosynthetic genes in Nicotiana benthamiana led to citronellol production. Our genomic and metabolomic analyses suggested that the copy number of NUDX1-1a determines the citronellol content in different rose species. Our findings not only provide additional genome and gene resources and reveal the evolution of the terpene biosynthetic pathways but also present a nearly complete scenario for terpenoid metabolism that will facilitate the breeding of fragrant roses and the production of rose oil.


Asunto(s)
Vías Biosintéticas , Rosa , Terpenos , Rosa/genética , Rosa/metabolismo , Terpenos/metabolismo , Vías Biosintéticas/genética , Transferasas Alquil y Aril/genética , Transferasas Alquil y Aril/metabolismo , Estudio de Asociación del Genoma Completo , Odorantes , Evolución Molecular , Genoma de Planta , Monoterpenos Acíclicos/metabolismo , Proteínas de Plantas/genética , Proteínas de Plantas/metabolismo
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