RESUMEN
Three new sesquiterpenoids, isodauc-7(14)-en-6alpha,10beta-diol (1), 10beta-hydroxyisodauc-6-en-14-al (2), and (7S(*))-opposit-4(15)-en-1beta,7-diol (4), along with ten known compounds have been isolated from the aerial parts of Senecio argunensis. Their structures were established by means of detailed spectroscopic analysis including IR, HR-MS, and 1D NMR and 2D NMR data. The sesquiterpenoids were assayed against Escherichia coli, Staphylococcus aureus and Bacillus subtilis. Compounds 4 exhibited weak antibacterial activity against Escherichia coli and Bacillus subtilis.
Asunto(s)
Antibacterianos/química , Senecio/química , Sesquiterpenos/química , Antibacterianos/aislamiento & purificación , Antibacterianos/farmacología , Espectroscopía de Resonancia Magnética , Pruebas de Sensibilidad Microbiana , Conformación Molecular , Extractos Vegetales/química , Sesquiterpenos/aislamiento & purificación , Sesquiterpenos/farmacologíaRESUMEN
From the whole plants of Aster himalaicus, a new eudesmane-type sesquiterpene, 1-oxoeudesm-11(13)-eno-12,8alpha-lactone, along with twelve known compounds, was isolated. The structures of all compounds have been elucidated on the basis of spectroscopic data, including IR, EI-MS, HR-ESI-MS, and 1D- and 2D-NMR data.