RESUMEN
BACKGROUND: Numerous etiologic agents of subcutaneous phaeohyphomycosis have been reported. Colletotrichum spp, common plant pathogens, have been reported as a cause of ocular keratomycosis, but only one previous case of cutaneous disease (hyalohyphomycosis) has been attributed to this genus. OBJECTIVE: Our purpose was to describe 3 cases of subcutaneous phaeohyphomycosis due to Colletotrichum spp occurring in patients undergoing chemotherapy for hematologic malignancies. METHODS: Three cases of Colletotrichum-induced phaeohyphomycosis are reviewed. The clinical and histologic features of this infection are presented, the antifungal susceptibilities are reported, and treatment options are discussed. RESULTS: We describe the first report in which C coccodes and C gloeosporioides are implicated as etiologic agents of subcutaneous phaeohyphomycosis. Despite treatment, one patient died after the onset of visceral fungal disease. CONCLUSION: Colletotrichum spp may cause life-threatening phaeohyphomycosis in immunosuppressed patients. Prompt recognition and intervention with surgical and antifungal treatment may result in decreased morbidity and mortality associated with these infections.
Asunto(s)
Colletotrichum/patogenicidad , Neoplasias Hematológicas/complicaciones , Micosis/patología , Adulto , Antifúngicos/uso terapéutico , Resultado Fatal , Neoplasias Hematológicas/microbiología , Humanos , Huésped Inmunocomprometido , Masculino , Persona de Mediana Edad , Morbilidad , Micosis/terapiaAsunto(s)
Infecciones Oportunistas Relacionadas con el SIDA/patología , Síndrome de Inmunodeficiencia Adquirida/patología , Dermatomicosis/patología , Histoplasmosis/patología , Infecciones Oportunistas Relacionadas con el SIDA/tratamiento farmacológico , Síndrome de Inmunodeficiencia Adquirida/complicaciones , Síndrome de Inmunodeficiencia Adquirida/inmunología , Adulto , Anfotericina B/administración & dosificación , Anfotericina B/uso terapéutico , Antifúngicos/administración & dosificación , Antifúngicos/uso terapéutico , Dermatomicosis/tratamiento farmacológico , Histoplasma/aislamiento & purificación , Histoplasmosis/tratamiento farmacológico , Humanos , Huésped Inmunocomprometido , Inyecciones Intravenosas , Itraconazol/uso terapéutico , Masculino , RecurrenciaRESUMEN
The d'embleé variant of mycosis fungoides initially described patients with a rapid onset of tumors without progression through patch- and plaque-stage disease. We report a case of a patient with the clinical presentation of mycosis fungoides d'embleé and correlate the histologic and immunophenotypic data with those of a more updated classification scheme.
Asunto(s)
Linfoma de Células B Grandes Difuso/patología , Micosis Fungoide/patología , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Progresión de la Enfermedad , Cara/patología , Humanos , Antígeno Ki-1/análisis , Linfoma de Células B Grandes Difuso/inmunología , Linfoma de Células B Grandes Difuso/terapia , Masculino , Persona de Mediana Edad , Micosis Fungoide/inmunología , Micosis Fungoide/terapia , Radioterapia Adyuvante , Resultado del TratamientoRESUMEN
Recent cancer statistics estimate that the yearly incidence of cutaneous malignancies in the United States is similar to the incidence of all other cancers combined. Ultraviolet radiation-induced photodamage of the skin plays a large role in the growth of these skin cancers. The case of a 47-year-old white man with peculiar patterns of actinic skin damage on the anterior chest and back is presented, and the relationship of these findings with his choice of clothing is reviewed. The transmission of ultraviolet radiation through clothing fabrics is addressed, with recommendations for the use of clothing as an effective form of photoprotection.