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1.
BMJ Open ; 9(7): e026423, 2019 07 11.
Artículo en Inglés | MEDLINE | ID: mdl-31300496

RESUMEN

OBJECTIVES: The aims of the present study were to assess the association and interactions of physical workload and poor health with health-related job loss (HRJL) among older workers, and the association and interactions of occupational social class and poor health with HRJL. METHODS: Data were used from an existing prospective cohort study, Health and Employment after Fifty, where employed or self-employed workers aged 50-64 years (n=4909) were followed-up between 2014 and 2016. Associations between potential determinants (self-perceived health status, physical workload and occupational social class) and 2-year HRJL were examined by Cox regression analyses. To study whether physical workload or occupational social class moderates the influence of poor health on HRJL, additive and multiplicative interactions were calculated. RESULTS: Older workers with poor self-perceived health status had increased risk of HRJL during the 2-year follow-up period (men: HR 2.57 (95%CI: 1.68 to 3.92); women: HR 3.26 (95%CI: 2.33 to 4.55)). Furthermore, men with high physical workload were at increased risk for HRJL (HR 1.63 (95%CI: 1.09 to 2.43)). No significant interactions (p<0.05) were identified between poor health and high physical workload, nor between poor health and lower occupational social class. CONCLUSION: Our study indicates that older workers in poor health, and older workers with a physically demanding job, are at increased risk of HRJL. Having a physically demanding job or working in routine/manual occupations does not moderate the association between poor health and HRJL.


Asunto(s)
Estado de Salud , Ocupaciones , Clase Social , Desempleo/estadística & datos numéricos , Carga de Trabajo , Femenino , Humanos , Masculino , Persona de Mediana Edad , Estudios Prospectivos , Factores de Riesgo , Reino Unido
2.
Fam Pract ; 36(2): 179-186, 2019 03 20.
Artículo en Inglés | MEDLINE | ID: mdl-29878103

RESUMEN

BACKGROUND: Arm pain is common, costly to health services and society. Physiotherapy referral is standard management, and while awaiting treatment, advice is often given to rest, but the evidence base is weak. OBJECTIVE: To assess the cost-effectiveness of advice to remain active (AA) versus advice to rest (AR); and immediate physiotherapy (IP) versus usual care (waiting list) physiotherapy (UCP). METHODS: Twenty-six-week within-trial economic evaluation (538 participants aged ≥18 years randomized to usual care, i.e. AA (n = 178), AR (n = 182) or IP (n = 178). Regression analysis estimated differences in mean costs and Quality-Adjusted Life Years (QALYs). Incremental cost-effectiveness ratios (ICERs) and cost-effectiveness acceptability curves were generated. Primary analysis comprised the 193 patients with complete resource use (UK NHS perspective) and EQ-5D data. Sensitivity analysis investigated uncertainty. RESULTS: Baseline-adjusted cost differences were £88 [95% confidence interval (CI): -14, 201) AA versus AR; -£14 (95% CI: -87, 66) IP versus UCP. Baseline-adjusted QALY differences were 0.0095 (95% CI: -0.0140, 0.0344) AA versus AR; 0.0143 (95% CI: -0.0077, 0.0354) IP versus UCP. There was a 71 and 89% probability that AA (versus AR) and IP (versus UCP) were the most cost-effective option using a threshold of £20,000 per additional QALY.  The results were robust in the sensitivity analysis. CONCLUSION: The difference in mean costs and mean QALYs between the competing strategies was small and not statistically significant. However, decision-makers may judge that IP was not shown to be any more effective than delayed treatment, and was no more costly than delayed physiotherapy. AA is preferable to one that encourages AR, as it is more effective and more likely to be cost-effective than AR.


Asunto(s)
Brazo , Ejercicio Físico/fisiología , Dolor/rehabilitación , Modalidades de Fisioterapia/economía , Análisis Costo-Beneficio , Femenino , Humanos , Masculino , Persona de Mediana Edad , Manejo del Dolor , Años de Vida Ajustados por Calidad de Vida , Ensayos Clínicos Controlados Aleatorios como Asunto , Descanso
3.
Occup Med (Lond) ; 67(6): 448-452, 2017 Aug 01.
Artículo en Inglés | MEDLINE | ID: mdl-28892874

RESUMEN

BACKGROUND: While analysing trends in occupational mortality in England and Wales, we noticed an unexpectedly elevated proportion of deaths from multiple sclerosis (MS) among men in the armed forces. AIMS: To document and explore possible explanations for the observed excess. METHODS: We analysed data on underlying cause of death and last full-time occupation for 3,688,916 deaths among men aged 20-74 years in England and Wales during 1979-2010, calculating proportional mortality ratios (PMRs) standardised for age. We compared PMRs for MS in the armed forces with those for each main social class, and in selected other occupations. We also compared PMRs for MS with those for motor neurone disease (MND). RESULTS: The overall PMR for MS in the armed forces during 1979-2010 was 243 (95%CI 203-288). The excess was apparent in each of three separate decades of study (PMRs, ranging from 220 to 259), and across the entire age range. PMRs for MS were not elevated to the same extent in comparator occupations, nor in any of the main social classes. There was no parallel increase in PMRs for MND. CONCLUSIONS: These findings suggest that the high proportional mortality from MS in British military personnel is unlikely to have occurred by chance, or as an artefact of the method of investigation. However, the only military cohort study with published results on MS does not support an increased risk. It would be useful to analyse data on MS from other established military cohorts, to check for evidence of a hazard.


Asunto(s)
Personal Militar/estadística & datos numéricos , Esclerosis Múltiple/mortalidad , Adulto , Anciano , Esclerosis Amiotrófica Lateral/mortalidad , Causas de Muerte , Estudios de Cohortes , Inglaterra/epidemiología , Humanos , Masculino , Persona de Mediana Edad , Exposición Profesional/efectos adversos , Ocupaciones/estadística & datos numéricos , Clase Social , Gales/epidemiología
4.
Scand J Work Environ Health ; 43(2): 136-145, 2017 03 01.
Artículo en Inglés | MEDLINE | ID: mdl-28052164

RESUMEN

Objectives The aim of this study was to characterize the descriptive epidemiology of insomnia in midlife and explore the relative importance of different occupational risk factors for insomnia among older workers. Methods A questionnaire was mailed to all adults aged 50-64 years registered with 24 English general practices. Insomnia was defined as having at least one of four problems with sleep severely in the past three months. Subjects were also asked about employment conditions, feelings concerning work, and their health. Associations were assessed by logistic regression and population attributable fractions (PAF) calculated. Results Analysis was based on 8067 respondents (5470 in paid work), 18.8% of whom reported insomnia. It was more common among women, smokers, obese individuals, those living alone, and those in financial hardship, and less prevalent among the educated, those in South-East England, and those with friendships and leisure-time pursuits. Occupational risk factors included unemployment, shift working, lack of control and support at work, job insecurity, job dissatisfaction and several of its determinants (lacking a sense of achievement, feeling unappreciated, having difficult work colleagues, feeling unfairly criticized). Population burden of insomnia was associated more strongly with difficulties in coping with work demands, job insecurity, difficult colleagues, and lack of friendships at work [population attributable fraction (PAF) 15-33%] than shift work and lack of autonomy or support (PAF 5-7%). It was strongly associated with seven measures of poorer self-assessed health. Conclusions Employment policies aimed at tackling insomnia among older workers may benefit from focusing particularly on job-person fit, job security and relationships in the workplace.


Asunto(s)
Empleo/psicología , Exposición Profesional/efectos adversos , Trastornos del Inicio y del Mantenimiento del Sueño/epidemiología , Logro , Factores de Edad , Inglaterra/epidemiología , Femenino , Humanos , Satisfacción en el Trabajo , Masculino , Persona de Mediana Edad , Prevalencia , Factores de Riesgo , Factores Sexuales , Encuestas y Cuestionarios , Lugar de Trabajo
5.
Occup Environ Med ; 74(7): 476-482, 2017 07.
Artículo en Inglés | MEDLINE | ID: mdl-28062832

RESUMEN

OBJECTIVES: Demographic changes are requiring people to work longer. No previous studies, however, have focused on whether the 'frailty' phenotype (which predicts adverse events in the elderly) is associated with employment difficulties. To provide information, we assessed associations in the Health and Employment After Fifty Study, a population-based cohort of 50-65-year olds. METHODS: Subjects, who were recruited from 24 English general practices, completed a baseline questionnaire on 'prefrailty' and 'frailty' (adapted Fried criteria) and several work outcomes, including health-related job loss (HRJL), prolonged sickness absence (>20 days vs less, past 12 months), having to cut down substantially at work and difficulty coping with work's demands. Associations were assessed using logistic regression and population attributable fractions (PAFs) were calculated. RESULTS: In all, 3.9% of 8095 respondents were classed as 'frail' and 31.6% as 'prefrail'. Three-quarters of the former were not in work, while 60% had left their last job on health grounds (OR for HRJL vs non-frail subjects, 30.0 (95% CI 23.0 to 39.2)). Among those in work, ORs for prolonged sickness absence, cutting down substantially at work and struggling with work's physical demands ranged from 10.7 to 17.2. The PAF for HRJL when any frailty marker was present was 51.8% and that for prolonged sickness absence was 32.5%. Associations were strongest with slow reported walking speed. Several associations were stronger in manual workers than in managers. CONCLUSIONS: Fried frailty symptoms are not uncommon in mid-life and are strongly linked with economically important adverse employment outcomes. Frailty could represent an important target for prevention.


Asunto(s)
Empleo/estadística & datos numéricos , Evaluación Geriátrica/estadística & datos numéricos , Ausencia por Enfermedad/estadística & datos numéricos , Anciano , Empleo/psicología , Inglaterra , Ejercicio Físico , Femenino , Medicina General , Evaluación Geriátrica/métodos , Humanos , Modelos Logísticos , Masculino , Trastornos Mentales/epidemiología , Persona de Mediana Edad , Enfermedades Musculoesqueléticas/epidemiología , Prevalencia , Encuestas y Cuestionarios
6.
Spine (Phila Pa 1976) ; 42(10): 740-747, 2017 May 15.
Artículo en Inglés | MEDLINE | ID: mdl-27820794

RESUMEN

STUDY DESIGN: A cross-sectional survey with a longitudinal follow-up. OBJECTIVES: The aim of this study was to test the hypothesis that pain, which is localized to the low back, differs epidemiologically from that which occurs simultaneously or close in time to pain at other anatomical sites SUMMARY OF BACKGROUND DATA.: Low back pain (LBP) often occurs in combination with other regional pain, with which it shares similar psychological and psychosocial risk factors. However, few previous epidemiological studies of LBP have distinguished pain that is confined to the low back from that which occurs as part of a wider distribution of pain. METHODS: We analyzed data from CUPID, a cohort study that used baseline and follow-up questionnaires to collect information about musculoskeletal pain, associated disability, and potential risk factors, in 47 occupational groups (office workers, nurses, and others) from 18 countries. RESULTS: Among 12,197 subjects at baseline, 609 (4.9%) reported localized LBP in the past month, and 3820 (31.3%) nonlocalized LBP. Nonlocalized LBP was more frequently associated with sciatica in the past month (48.1% vs. 30.0% of cases), occurred on more days in the past month and past year, was more often disabling for everyday activities (64.1% vs. 47.3% of cases), and had more frequently led to medical consultation and sickness absence from work. It was also more often persistent when participants were followed up after a mean of 14 months (65.6% vs. 54.1% of cases). In adjusted Poisson regression analyses, nonlocalized LBP was differentially associated with risk factors, particularly female sex, older age, and somatizing tendency. There were also marked differences in the relative prevalence of localized and nonlocalized LBP by occupational group. CONCLUSION: Future epidemiological studies should distinguish where possible between pain that is limited to the low back and LBP that occurs in association with pain at other anatomical locations. LEVEL OF EVIDENCE: 2.


Asunto(s)
Dolor de la Región Lumbar/epidemiología , Adulto , Distribución por Edad , Estudios de Cohortes , Estudios Transversales , Femenino , Humanos , Incidencia , Dolor de la Región Lumbar/diagnóstico , Masculino , Persona de Mediana Edad , Enfermedades Profesionales/diagnóstico , Enfermedades Profesionales/epidemiología , Prevalencia , Factores de Riesgo , Caracteres Sexuales , Encuestas y Cuestionarios
7.
Occup Environ Med ; 73(8): 512-9, 2016 08.
Artículo en Inglés | MEDLINE | ID: mdl-27152012

RESUMEN

OBJECTIVES: Demographic changes are requiring people to work longer. Labour force participation might be promoted by tackling sources of job dissatisfaction. We aimed to describe the epidemiology of job dissatisfaction in older British workers, to explore which perceptions of work contribute most importantly, and to assess possible impacts on health. METHODS: Participants aged 50-64 years were recruited from 24 English general practices. At baseline, those currently in work (N=5437) reported on their demographic and employment circumstances, overall job satisfaction, perceptions of their work that might contribute to dissatisfaction, and their general health, mood and well-being. Associations of job dissatisfaction with risk factors and potential health outcomes were assessed cross-sectionally by logistic regression, and the potential contributions of different negative perceptions to overall dissatisfaction were summarised by population attributable fractions (PAFs). RESULTS: Job dissatisfaction was more common among men, below age 60 years, those living in London and the South East, in the more educated and in those working for larger employers. The main contributors to job dissatisfaction among employees were feeling unappreciated and/or lacking a sense of achievement (PAF 55-56%), while in the self-employed, job insecurity was the leading contributor (PAF 79%). Job dissatisfaction was associated with all of the adverse health outcomes examined (ORs of 3-5), as were most of the negative perceptions of work that contributed to overall dissatisfaction. CONCLUSIONS: Employment policies aimed at improving job satisfaction in older workers may benefit from focussing particularly on relationships in the workplace, fairness, job security and instilling a sense of achievement.


Asunto(s)
Empleo/psicología , Satisfacción en el Trabajo , Exposición Profesional , Trabajo , Lugar de Trabajo , Logro , Factores de Edad , Estudios Transversales , Inglaterra , Femenino , Salud , Humanos , Modelos Logísticos , Londres , Masculino , Persona de Mediana Edad , Oportunidad Relativa , Factores de Riesgo , Factores Sexuales , Estrés Psicológico
9.
PLoS One ; 11(4): e0153748, 2016.
Artículo en Inglés | MEDLINE | ID: mdl-27128094

RESUMEN

Somatising tendency, defined as a predisposition to worry about common somatic symptoms, is importantly associated with various aspects of health and health-related behaviour, including musculoskeletal pain and associated disability. To explore its epidemiological characteristics, and how it can be specified most efficiently, we analysed data from an international longitudinal study. A baseline questionnaire, which included questions from the Brief Symptom Inventory about seven common symptoms, was completed by 12,072 participants aged 20-59 from 46 occupational groups in 18 countries (response rate 70%). The seven symptoms were all mutually associated (odds ratios for pairwise associations 3.4 to 9.3), and each contributed to a measure of somatising tendency that exhibited an exposure-response relationship both with multi-site pain (prevalence rate ratios up to six), and also with sickness absence for non-musculoskeletal reasons. In most participants, the level of somatising tendency was little changed when reassessed after a mean interval of 14 months (75% having a change of 0 or 1 in their symptom count), although the specific symptoms reported at follow-up often differed from those at baseline. Somatising tendency was more common in women than men, especially at older ages, and varied markedly across the 46 occupational groups studied, with higher rates in South and Central America. It was weakly associated with smoking, but not with level of education. Our study supports the use of questions from the Brief Symptom Inventory as a method for measuring somatising tendency, and suggests that in adults of working age, it is a fairly stable trait.


Asunto(s)
Síntomas sin Explicación Médica , Trastornos Somatomorfos/epidemiología , Adulto , Actitud Frente a la Salud , América Central , Femenino , Humanos , Estudios Longitudinales , Masculino , Persona de Mediana Edad , Dolor Musculoesquelético/epidemiología , Enfermedades Profesionales/epidemiología , Ocupaciones , Oportunidad Relativa , Prevalencia , América del Sur , Encuestas y Cuestionarios , Adulto Joven
10.
Occup Environ Med ; 73(6): 385-93, 2016 06.
Artículo en Inglés | MEDLINE | ID: mdl-26976946

RESUMEN

OBJECTIVES: To monitor the impact of health and safety provisions and inform future preventive strategies, we investigated trends in mortality from established occupational hazards in England and Wales. METHODS: We analysed data from death certificates on underlying cause of death and last full-time occupation for 3 688 916 deaths among men aged 20-74 years in England and Wales during 1979-2010 (excluding 1981 when records were incomplete). Proportional mortality ratios (PMRs), standardised for age and social class, were calculated for occupations at risk of specified hazards. Observed and expected numbers of deaths for each hazard were summed across occupations, and the differences summarised as average annual excesses. RESULTS: Excess mortality declined substantially for most hazards. For example, the annual excess of deaths from chronic bronchitis and emphysema fell from 170.7 during 1979-1990 to 36.0 in 2001-2010, and that for deaths from injury and poisoning from 237.0 to 87.5. In many cases, the improvements were associated with falling PMRs (suggesting safer working practices), but they also reflected reductions in the numbers of men employed in more hazardous jobs, and declining mortality from some diseases across the whole population. Notable exceptions to the general improvement were diseases caused by asbestos, especially in some construction trades and sinonasal cancer in woodworkers. CONCLUSIONS: The highest priority for future prevention of work-related fatalities is the minority of occupational disorders for which excess mortality remains static or is increasing, in particular asbestos-related disease among certain occupations in the construction industry and sinonasal cancer in woodworkers.


Asunto(s)
Enfermedades Profesionales/mortalidad , Exposición Profesional/efectos adversos , Adulto , Anciano , Causas de Muerte , Certificado de Defunción , Inglaterra/epidemiología , Humanos , Masculino , Persona de Mediana Edad , Traumatismos Ocupacionales/mortalidad , Ocupaciones/clasificación , Modelos de Riesgos Proporcionales , Gales/epidemiología , Heridas y Lesiones/mortalidad , Adulto Joven
11.
Pain ; 157(5): 1028-1036, 2016 May.
Artículo en Inglés | MEDLINE | ID: mdl-26761390

RESUMEN

To inform case definition for neck/shoulder pain in epidemiological research, we compared levels of disability, patterns of association, and prognosis for pain that was limited to the neck or shoulders (LNSP) and more generalised musculoskeletal pain that involved the neck or shoulder(s) (GPNS). Baseline data on musculoskeletal pain, disability, and potential correlates were collected by questionnaire from 12,195 workers in 47 occupational groups (mostly office workers, nurses, and manual workers) in 18 countries (response rate = 70%). Continuing pain after a mean interval of 14 months was ascertained through a follow-up questionnaire in 9150 workers from 45 occupational groups. Associations with personal and occupational factors were assessed by Poisson regression and summarised by prevalence rate ratios (PRRs). The 1-month prevalence of GPNS at baseline was much greater than that of LNSP (35.1% vs 5.6%), and it tended to be more troublesome and disabling. Unlike LNSP, the prevalence of GPNS increased with age. Moreover, it showed significantly stronger associations with somatising tendency (PRR 1.6 vs 1.3) and poor mental health (PRR 1.3 vs 1.1); greater variation between the occupational groups studied (prevalence ranging from 0% to 67.6%) that correlated poorly with the variation in LNSP; and was more persistent at follow-up (72.1% vs 61.7%). Our findings highlight important epidemiological distinctions between subcategories of neck/shoulder pain. In future epidemiological research that bases case definitions on symptoms, it would be useful to distinguish pain that is localised to the neck or shoulder from more generalised pain that happens to involve the neck/shoulder region.


Asunto(s)
Personas con Discapacidad , Dolor de Cuello , Enfermedades Profesionales/epidemiología , Dolor de Hombro , Adulto , Distribución por Edad , Factores de Edad , Estudios Epidemiológicos , Femenino , Estudios de Seguimiento , Humanos , Cooperación Internacional , Masculino , Salud Mental , Persona de Mediana Edad , Dolor de Cuello/complicaciones , Dolor de Cuello/epidemiología , Dolor de Cuello/psicología , Prevalencia , Factores de Riesgo , Dolor de Hombro/complicaciones , Dolor de Hombro/epidemiología , Dolor de Hombro/patología , Encuestas y Cuestionarios , Adulto Joven
12.
J Allergy Clin Immunol ; 137(2): 527-534.e7, 2016 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-26277596

RESUMEN

BACKGROUND: Welders are at increased risk of pneumococcal pneumonia. The mechanism for this association is not known. The capacity of pneumococci to adhere to and infect lower airway cells is mediated by host-expressed platelet-activating factor receptor (PAFR). OBJECTIVE: We sought to assess the effect of mild steel welding fumes (MS-WF) on PAFR-dependent pneumococcal adhesion and infection to human airway cells in vitro and on pneumococcal airway infection in a mouse model. METHODS: The oxidative potential of MS-WF was assessed by their capacity to reduce antioxidants in vitro. Pneumococcal adhesion and infection of A549, BEAS-2B, and primary human bronchial airway cells were assessed by means of quantitative bacterial culture and expressed as colony-forming units (CFU). After intranasal instillation of MS-WF, mice were infected with Streptococcus pneumoniae, and bronchoalveolar lavage fluid (BALF) and lung CFU values were determined. PAFR protein levels were assessed by using immunofluorescence and immunohistochemistry, and PAFR mRNA expression was assessed by using quantitative PCR. PAFR was blocked by CV-3988, and oxidative stress was attenuated by N-acetylcysteine. RESULTS: MS-WF exhibited high oxidative potential. In A549 and BEAS-2B cells MS-WF increased pneumococcal adhesion and infection and PAFR protein expression. Both CV-3988 and N-acetylcysteine reduced MS-WF-stimulated pneumococcal adhesion and infection of airway cells. MS-WF increased mouse lung PAFR mRNA expression and increased BALF and lung pneumococcal CFU values. In MS-WF-exposed mice CV-3988 reduced BALF CFU values. CONCLUSIONS: Hypersusceptibility of welders to pneumococcal pneumonia is in part mediated by the capacity of welding fumes to increase PAFR-dependent pneumococcal adhesion and infection of lower airway cells.


Asunto(s)
Exposición Profesional/efectos adversos , Neumonía Neumocócica/etiología , Neumonía Neumocócica/microbiología , Streptococcus pneumoniae , Soldadura , Animales , Adhesión Bacteriana , Carga Bacteriana , Líquido del Lavado Bronquioalveolar , Línea Celular , Modelos Animales de Enfermedad , Susceptibilidad a Enfermedades , Femenino , Expresión Génica , Intoxicación por Metales Pesados , Humanos , Ratones , Estrés Oxidativo , Glicoproteínas de Membrana Plaquetaria/genética , Glicoproteínas de Membrana Plaquetaria/metabolismo , Neumonía Neumocócica/metabolismo , Intoxicación , ARN Mensajero/genética , Receptores Acoplados a Proteínas G/genética , Receptores Acoplados a Proteínas G/metabolismo , Mucosa Respiratoria/inmunología , Mucosa Respiratoria/metabolismo , Mucosa Respiratoria/microbiología
13.
Best Pract Res Clin Rheumatol ; 29(3): 391-404, 2015 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-26612237

RESUMEN

Changing demographics mean that many patients with soft tissue rheumatism, osteoarthritis, inflammatory arthritis, large joint prostheses and age-related co-morbidities are seeking to work beyond the traditional retirement age. In this chapter, we review the evidence on musculoskeletal health and work at older ages. We conclude that musculoskeletal problems are common in older workers and have a substantial impact on their work capacity. Factors that influence their job retention are described, together with approaches that may extend working life. Many gaps in evidence were found, notably on the health risks and benefits of continued work in affected patients and on which interventions work best. The roles of physicians and managers are also considered.


Asunto(s)
Envejecimiento/fisiología , Enfermedades Musculoesqueléticas/fisiopatología , Sistema Musculoesquelético/fisiopatología , Anciano , Evaluación de la Discapacidad , Humanos , Evaluación de Capacidad de Trabajo
14.
Best Pract Res Clin Rheumatol ; 29(3): 424-39, 2015 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-26612239

RESUMEN

Occupational exposures to vibration come in many guises, and they are very common at a population level. It follows that an important minority of working-aged patients seen by medical services will have been exposed to this hazard of employment. Vibration can cause human health effects, which may manifest in the patients that rheumatologists see. In this chapter, we identify the health effects of relevance to them, and review their epidemiology, pathophysiology, clinical presentation, differential diagnosis and vocational and clinical management. On either side of this, we describe the nature and assessment of the hazard, the scale and common patterns of exposure to vibration in the community and the legal basis for controlling health risks, and we comment on the role of health surveillance in detecting early adverse effects and what can be done to prevent the rheumatic effects of vibration at work.


Asunto(s)
Enfermedades Profesionales/etiología , Exposición Profesional/efectos adversos , Enfermedades Reumáticas/etiología , Vibración/efectos adversos , Diagnóstico Diferencial , Empleo , Humanos , Enfermedades Profesionales/epidemiología , Enfermedades Profesionales/fisiopatología , Enfermedades Reumáticas/epidemiología , Enfermedades Reumáticas/fisiopatología , Factores de Riesgo
15.
BMC Public Health ; 15: 1071, 2015 Oct 19.
Artículo en Inglés | MEDLINE | ID: mdl-26482655

RESUMEN

BACKGROUND: Demographic trends in developed countries have prompted governmental policies aimed at extending working lives. However, working beyond the traditional retirement age may not be feasible for those with major health problems of ageing, and depending on occupational and personal circumstances, might be either good or bad for health. To address these uncertainties, we have initiated a new longitudinal study. METHODS/DESIGN: We recruited some 8000 adults aged 50-64 years from 24 British general practices contributing to the Clinical Practice Research Datalink (CPRD). Participants have completed questionnaires about their work and home circumstances at baseline, and will do so regularly over follow-up, initially for a 5-year period. With their permission, we will access their primary care health records via the CPRD. The inter-relation of changes in employment (with reasons) and changes in health (e.g., major new illnesses, new treatments, mortality) will be examined. DISCUSSION: CPRD linkage allows cost-effective frequent capture of detailed objective health data with which to examine the impact of health on work at older ages and of work on health. Findings will inform government policy and also the design of work for older people and the measures needed to support employment in later life, especially for those with health limitations.


Asunto(s)
Envejecimiento , Empleo , Estado de Salud , Salud , Jubilación , Trabajo , Femenino , Humanos , Estudios Longitudinales , Masculino , Persona de Mediana Edad , Estudios Prospectivos , Proyectos de Investigación , Encuestas y Cuestionarios , Reino Unido
16.
Work ; 53(2): 313-23, 2015.
Artículo en Inglés | MEDLINE | ID: mdl-26409386

RESUMEN

BACKGROUND: Only few longitudinal studies have explored separately predictors of pain incidence and persistence. OBJECTIVE: To investigate whether biological, lifestyle, occupational and psychological risk factors for the development of new episodes of upper limb pain (ULP) differ from those for its persistence. METHODS: Spanish nurses and office workers (1105) were asked at baseline about biological, lifestyle, occupational and psychological risk factors and pain in the past month at six anatomical sites in the upper limb (left and right shoulder, elbow and wrist/hand). At follow up, 12 months later, pain in the past month was again ascertained. Analysis was based on anatomical sites clustered by person. Associations were assessed by multilevel logistic regression models. RESULTS: Nine hundred and seventy-one participants (87.9%) completed follow-up. Job dissatisfaction and older age carried higher risk of new ULP. Somatising tendency (OR 2.2, 95% CI 1.6-3.1) was the strongest predictor of new ULP, with a risk estimate which differed significantly from that for the same exposure and persistence of ULP. Having adverse beliefs about the work-relatedness of ULP carried a significantly reduced risk for persistence of ULP. CONCLUSION: Our study provides only limited evidence that risk factors predicting new ULP differ from those predicting its persistence.


Asunto(s)
Enfermedades Profesionales/etiología , Dolor/etiología , Extremidad Superior , Adulto , Femenino , Humanos , Incidencia , Estilo de Vida , Estudios Longitudinales , Masculino , Persona de Mediana Edad , Dimensión del Dolor , Factores de Riesgo , España , Encuestas y Cuestionarios
17.
Occup Environ Med ; 72(6): 435-41, 2015 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-25694496

RESUMEN

OBJECTIVES: To provide further information on the possible carcinogenicity of phenoxy herbicides, and in particular their relationship to soft tissue sarcoma (STS), non-Hodgkin's lymphoma (NHL) and chronic lymphocytic leukaemia (CLL). METHODS: We extended follow-up to December 2012 for 8036 men employed at five factories in the UK which had manufactured phenoxy herbicides, or in a contract spraying business. Mortality was compared with that for England and Wales by the person-years method. Nested case-control analyses compared men with incident or fatal STS (n=15) or NHL/CLL (n=74) and matched controls (up to 10 per case). RESULTS: 4093 men had died, including 2303 since the last follow-up. Mortality from all causes and all cancers was close to expectation, but an excess of deaths from NHL was observed among men who had worked for ≥1 year in jobs with more than background exposure to phenoxy herbicides (19 deaths, SMR 1.85, 95% CI 1.12 to 2.89). Four deaths from STS occurred among men potentially exposed above background (3.3 expected). In the nested case-control analyses, there were no significantly elevated risks or consistent trends across categories of potential exposure for either STS or NHL/CLL. Among men who had worked for ≥1 year in potentially exposed jobs, the highest OR (for STS) was only 1.30 (95% CI 0.30 to 5.62). CONCLUSIONS: Our findings are consistent with the current balance of epidemiological evidence. If phenoxy herbicides pose a hazard of either STS or NHL, then any absolute increase in risk is likely to be small.


Asunto(s)
Herbicidas/toxicidad , Leucemia Linfocítica Crónica de Células B/inducido químicamente , Linfoma no Hodgkin/inducido químicamente , Enfermedades Profesionales/inducido químicamente , Exposición Profesional/efectos adversos , Sarcoma/inducido químicamente , Neoplasias de los Tejidos Blandos/inducido químicamente , Adulto , Estudios de Casos y Controles , Femenino , Estudios de Seguimiento , Humanos , Leucemia Linfocítica Crónica de Células B/mortalidad , Linfoma no Hodgkin/mortalidad , Masculino , Persona de Mediana Edad , Enfermedades Profesionales/mortalidad , Fenoles/toxicidad , Sarcoma/mortalidad , Neoplasias de los Tejidos Blandos/mortalidad , Reino Unido/epidemiología
19.
Occup Environ Med ; 72(3): 165-70, 2015 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-25358742

RESUMEN

OBJECTIVES: To provide further information on the risks of lymphohaematopoietic (LH) and other cancers associated with styrene. METHODS: We extended follow-up to December 2012 for 7970 workers at eight companies in England which used styrene in the manufacture of glass-reinforced plastics. Mortality was compared with that for England and Wales by the person-years method, and summarised by SMRs with 95% CIs. A supplementary nested case-control analysis compared styrene exposures, lagged by 5 years, in 122 incident or fatal cases of LH cancer and 1138 matched controls. RESULTS: A total of 3121 cohort members had died (2022 since the last follow-up). No elevation of mortality was observed for LH cancer, either in the full cohort (62 deaths, SMR 0.90, 95% CI 0.69 to 1.15), or in those with more than background exposure to styrene (38 deaths, SMR 0.82, 95% CI 0.58 to 1.14). Nor did the case-control analysis suggest any association with LH cancer. In comparison with background exposure, the OR for non-Hodgkin's lymphoma/chronic lymphocytic leukaemia in workers with high exposure (estimated 8-h time-weighted average of 40-100 ppm) for ≥1 year was 0.54 (95% CI 0.23 to 1.27). Mortality from lung cancer was significantly elevated, and risk increased progressively across exposure categories, with an SMR of 1.44 (95% CI 1.10 to 1.86) in workers highly exposed for ≥1 year. CONCLUSIONS: We found no evidence that styrene causes LH cancer. An association with lung cancer is not consistently supported by other studies. It may have been confounded by smoking, but would be worth checking further.


Asunto(s)
Neoplasias/inducido químicamente , Enfermedades Profesionales/inducido químicamente , Exposición Profesional/efectos adversos , Estirenos/toxicidad , Adulto , Estudios de Casos y Controles , Inglaterra/epidemiología , Femenino , Estudios de Seguimiento , Humanos , Industrias , Leucemia/inducido químicamente , Leucemia/mortalidad , Linfoma/inducido químicamente , Linfoma/mortalidad , Masculino , Persona de Mediana Edad , Neoplasias/mortalidad , Enfermedades Profesionales/mortalidad , Ocupaciones/clasificación , Plásticos , Factores de Riesgo , Factores de Tiempo
20.
Occup Environ Med ; 72(3): 195-9, 2015 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-25523936

RESUMEN

OBJECTIVES: Sensory impairments are becoming increasingly common in the workforces of Western countries. To assess their role in occupational injury, and that of disorders of balance, we undertook a case-control study. METHODS: Using the Clinical Practice Research Datalink, which documents all medical consultations, referrals and diagnoses in primary care for 6% of the British population, we identified 1348 working-aged patients who had consulted medical services over a 22-year period for workplace injury (cases) and 6652 age-matched, sex-matched and practice-matched controls. Risks were assessed by conditional logistic regression, for earlier recorded diagnoses of visual impairment, common eye diseases, hearing loss, perforated ear drum, non-acute otitis media and disorders of balance. RESULTS: In all, 173 (2.2%) participants had an earlier eye problem, 792 (9.9%) an ear problem (including 336 with impaired hearing and 482 with non-acute otitis media) and 266 (3.3%) a disorder of balance. No associations were found with glaucoma, cataract, retinal disorders or perforation of the ear drum specifically, but adjusted ORs were moderately elevated for eye and ear problems more generally, and higher where there was a record of blindness or partial sight (OR 1.90, 95% CI 1.05 to 3.44) or non-acute otitis media (OR 2.04, 95% CI 1.64 to 2.54). Risks for non-acute otitis media and for disorders of balance were particularly elevated for consultations in the 12 months preceding injury consultation (OR 2.70, 95% CI 1.58 to 4.62 and 1.77, 95% CI 1.01 to 3.11, respectively). CONCLUSIONS: Problems of vision, impairments of hearing and disorders of balance all may carry moderately increased risks of occupational injury.


Asunto(s)
Traumatismos Ocupacionales/etiología , Equilibrio Postural , Trastornos de la Sensación/complicaciones , Adolescente , Adulto , Estudios de Casos y Controles , Oftalmopatías/complicaciones , Femenino , Trastornos de la Audición/complicaciones , Humanos , Modelos Logísticos , Masculino , Persona de Mediana Edad , Medición de Riesgo , Factores de Riesgo , Reino Unido , Trastornos de la Visión/complicaciones , Adulto Joven
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