Effects of triclosan adsorption on intestinal toxicity and resistance gene expression in Xenopus tropicalis with different particle sizes of polystyrene.

Microplastics (MPs) are commonly found with hydrophobic contaminants in the water column and pose a serious threat to aquatic organisms. The effects of polystyrene microplastics of different particle sizes on the accumulation of triclosan in the gut of Xenopus tropicalis, its toxic effects, and the transmission of resistance genes were evaluated. The results showed that co-exposure to polystyrene (PS-MPs) adsorbed with triclosan (TCS) caused the accumulation of triclosan in the intestine with the following accumulation capacity: TCS + 5 µm PS group > TCS group > TCS + 20 µm PS group > TCS + 0.1 µm PS group. All experimental groups showed increased intestinal inflammation and antioxidant enzyme activity after 28 days of exposure to PS-MPs and TCS of different particle sizes. The TCS + 20 µm PS group exhibited the highest upregulated expression of pro-inflammatory factors (IL-10, IL-1ß). The TCS + 20 µm group showed the highest increase in enzyme activity compared to the control group. PS-MPs and TCS, either alone or together, altered the composition of the intestinal microbial community. In addition, the presence of more antibiotic resistance genes than triclosan resistance genes significantly increased the expression of tetracycline resistance and sulfonamide resistance genes, which may be associated with the development of intestinal inflammation and oxidative stress. This study refines the aquatic ecotoxicity assessment of TCS adsorbed by MPs and provides informative information for the management and control of microplastics and non-antibiotic bacterial inhibitors.

Effects of preventive care on psychological state and complications in leukemia patients receiving chemotherapy.

OBJECTIVE: To investigate the effects of preventive care on the psychological state and complications in patients with leukemia undergoing chemotherapy. METHODS: Retrospectively, 85 patients with leukemia undergoing chemotherapy in Xinchang People's Hospital from April 2019 to September 2021 were collected, including 47 patients who received preventive care as an observation group and 38 patients who received routine care as a control group. The incidence of chemotherapy-related complications, the scores of Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS) before and after nursing intervention, and the General Comfort Questionnaire (GCQ) and nursing satisfaction were compared between the two groups. RESULTS: The complication rate in the control group was higher than that of the observation group (P<0.05). The SAS and SDS scores of the control group were higher than those of the observation group after care (P<0.05). The GCQ score of the observation group was higher than that of the control group after care (P<0.05), and the care satisfaction of the control group was lower than that of the observation group (P<0.05). Multivariate Logistic regression analysis showed that age over 65 years old, platelet count less than 50 × 109/L and white blood cell count over 100 × 109/L were risk factors for complications in leukemia patients receiving chemotherapy (P<0.05). CONCLUSION: Preventive care helps to improve the negative emotions of patients with leukemia undergoing chemotherapy and reduces complications.