Recent advances in positron emission particle tracking: a comparative review.

Positron emission particle tracking (PEPT) is a technique which allows the high-resolution, three-dimensional imaging of particulate and multiphase systems, including systems which are large, dense, and/or optically opaque, and thus difficult to study using other methodologies. In this work, we bring together researchers from the world's foremost PEPT facilities not only to give a balanced and detailed overview and review of the technique but, for the first time, provide a rigorous, direct, quantitative assessment of the relative strengths and weaknesses of all contemporary PEPT methodologies. We provide detailed explanations of the methodologies explored, including also interactive code examples allowing the reader to actively explore, edit and apply the algorithms discussed. The suite of benchmarking tests performed and described within the document is made available in an open-source repository for future researchers.

Positron Emission Particle Tracking of Granular Flows.

Positron emission particle tracking (PEPT) is a noninvasive technique capable of imaging the three-dimensional dynamics of a wide variety of powders, particles, grains, and/or fluids. The PEPT technique can track the motion of particles with high temporal and spatial resolution and can be used to study various phenomena in systems spanning a broad range of scales, geometries, and physical states. We provide an introduction to the PEPT technique, an overview of its fundamental principles and operation, and a brief review of its application to a diverse range of scientific and industrial systems.

A randomised controlled trial and cost-consequence analysis of traditional and digital foot orthoses supply chains in a National Health Service setting: application to feet at risk of diabetic plantar ulceration.

BACKGROUND: Diabetic foot ulceration is a considerable cost to the NHS and foot orthotic provision is a core strategy for the management of the people with diabetes and a moderate to high risk of foot ulceration. The traditional process to produce a custom-made foot orthotic device is to use manual casting of foot shape and physical moulding of orthoses materials. Parts of this process can be undertaken using digital tools rather than manual processes with potential advantages. The aim of this trial was to provide the first comparison of a traditional orthoses supply chain to a digital supply chain over a 6 month period. The trial used plantar pressure, health status, and health service time and cost data to compare the two supply chains. METHODS: Fifty-seven participants with diabetes were randomly allocated to each supply chain. Plantar pressure data and health status (EQ5D, ICECAP) was assessed at point of supply and at six-months. The costs for orthoses and clinical services accessed by participants were assessed over the 6 months of the trial. Primary outcomes were: reduction in peak plantar pressure at the site of highest pressure, assessed for non-inferiority to current care. Secondary outcomes were: reduction in plantar pressure at foot regions identified as at risk (> 200 kPa), cost-consequence analysis (supply chain, clinician time, service use) and health status. RESULTS: At point of supply pressure reduction for the digital supply chain was non-inferior to a predefined margin and superior (p < 0.1) to the traditional supply chain, but both supply chains were inferior to the margin after 6 months. Custom-made orthoses significantly reduced pressure for at risk regions compared to a flat control (traditional - 13.85%, digital - 20.52%). The digital supply chain was more expensive (+£13.17) and required more clinician time (+ 35 min). There were no significant differences in health status or service use between supply chains. CONCLUSIONS: Custom made foot orthoses reduce pressure as expected. Given some assumptions about the cost models we used, the supply chain process adopted to produce the orthoses seems to have marginal impact on overall costs and health status. TRIAL REGISTRATION: Retrospectively registered on ISRCTN registry (ISRCTN10978940, 04/11/2015).

New Insight into Pseudo-Thermal Convection in Vibrofluidised Granular Systems.

Utilising a combination of experimental results obtained via positron emission particle tracking (PEPT) and numerical simulations, we study the influence of a system's geometric and elastic properties on the convective behaviours of a dilute, vibrofluidised granular assembly. Through the use of a novel, 'modular' system geometry, we demonstrate the existence of several previously undocumented convection-inducing mechanisms and compare their relative strengths across a broad, multi-dimensional parameter space, providing criteria through which the dominant mechanism within a given system - and hence its expected dynamics - may be predicted. We demonstrate a range of manners through which the manipulation of a system's geometry, material properties and imposed motion may be exploited in order to induce, suppress, strengthen, weaken or even invert granular convection. The sum of our results demonstrates that boundary-layer effects due to wall (in)elasticity or directional impulses due to 'rough' boundaries exert only a secondary influence on the system's behaviour. Rather, the direction and strength of convective motion is predominantly determined by the energy flux in the vicinity of the system's lateral boundaries, demonstrating unequivocally that pseudo-thermal granular convection is decidedly a collective phenomenon.

Positron emission particle tracking and its application to granular media.

Positron emission particle tracking (PEPT) is a technique for tracking a single radioactively labelled particle. Accurate 3D tracking is possible even when the particle is moving at high speed inside a dense opaque system. In many cases, tracking a single particle within a granular system provides sufficient information to determine the time-averaged behaviour of the entire granular system. After a general introduction, this paper describes the detector systems (PET scanners and positron cameras) used to record PEPT data, the techniques used to label particles, and the algorithms used to process the data. This paper concentrates on the use of PEPT for studying granular systems: the focus is mainly on work at Birmingham, but reference is also made to work from other centres, and options for wider diversification are suggested.

New Measurement of the Direct 3α Decay from the

Excited states in certain atomic nuclei possess an unusual structure, where the dominant degrees of freedom are those of α clusters rather than individual nucleons. It has been proposed that the diffuse 3α system of the ^{12}C Hoyle state may behave like a Bose-Einstein condensate, where the α clusters maintain their bosonic identities. By measuring the decay of the Hoyle state into three α particles, we obtained an upper limit for the rare direct 3α decay branch of 0.047%. This value is now at a level comparable with theoretical predictions and could be a sensitive probe of the structure of this state.

An experimental demonstration of a new type of proton computed tomography using a novel silicon tracking detector.

PURPOSE: Radiography and tomography using proton beams promise benefit to image guidance and treatment planning for proton therapy. A novel proton tracking detector is described and experimental demonstrations at a therapy facility are reported. A new type of proton CT reconstructing relative "scattering power" rather than "stopping power" is also demonstrated. Notably, this new type of imaging does not require the measurement of the residual energies of the protons. METHODS: A large area, silicon microstrip tracker with high spatial and temporal resolution has been developed by the Proton Radiotherapy Verification and Dosimetry Applications consortium and commissioned using beams of protons at iThemba LABS, Medical Radiation Department, South Africa. The tracker comprises twelve planes of silicon developed using technology from high energy physics with each plane having an active area of ∼10 × 10 cm segmented into 2048 microstrips. The tracker is organized into four separate units each containing three detectors at 60° to one another creating an x-u-v coordinate system. Pairs of tracking units are used to reconstruct vertices for protons entering and exiting a phantom containing tissue equivalent inserts. By measuring the position and direction of each proton before and after the phantom, the nonlinear path for each proton through an object can be reconstructed. RESULTS: Experimental results are reported for tracking the path of protons with initial energies of 125 and 191 MeV. A spherical phantom of 75 mm diameter was imaged by positioning it between the entrance and exit detectors of the tracker. Positions and directions of individual protons were used to create angular distributions and 2D fluence maps of the beam. These results were acquired for 36 equally spaced projections spanning 180°, allowing, for the first time, an experimental CT image based upon the relative scattering power of protons to be reconstructed. CONCLUSIONS: Successful tracking of protons through a thick target (phantom) has demonstrated that the tracker discussed in this paper can provide the precise directional information needed to perform proton radiography and tomography. When synchronized with a range telescope, this could enable the reconstruction of proton CT images of stopping power. Furthermore, by measuring the deflection of many protons through a phantom, it was demonstrated that it is possible to reconstruct a new kind of CT image (scattering power) based upon this tracking information alone.

Porous inverse vulcanised polymers for mercury capture.

Supercritical carbon dioxide is used to generate macroporosity in an inverse vulcanised polymer, which shows excellent promise for enhanced mercury capture and filtration from water.

Modifying self-assembly and species separation in three-dimensional systems of shape-anisotropic particles.

The behaviors of large, dynamic assemblies of macroscopic particles are of direct relevance to geophysical and industrial processes and may also be used as easily studied analogs to micro- or nano-scale systems, or model systems for microbiological, zoological, and even anthropological phenomena. We study vibrated mixtures of elongated particles, demonstrating that the inclusion of differing particle "species" may profoundly alter a system's dynamics and physical structure in various diverse manners. The phase behavior observed suggests that our system, despite its athermal nature, obeys a minimum free energy principle analogous to that observed for thermodynamic systems. We demonstrate that systems of exclusively spherical objects, which form the basis of numerous theoretical frameworks in many scientific disciplines, represent only a narrow region of a wide, multidimensional phase space. Thus, our results raise significant questions as to whether such models can accurately describe the behaviors of systems outside this highly specialized case.

Forced axial segregation in axially inhomogeneous rotating systems.

Controlling segregation is both a practical and a theoretical challenge. Using a novel drum design comprising concave and convex geometry, we explore, through the application of both discrete particle simulations and positron emission particle tracking, a means by which radial size segregation may be used to drive axial segregation, resulting in an order of magnitude increase in the rate of separation. The inhomogeneous drum geometry explored also allows the direction of axial segregation within a binary granular bed to be controlled, with a stable, two-band segregation pattern being reliably and reproducibly imposed on the bed for a variety of differing system parameters. This strong banding is observed to persist even in systems that are highly constrained in the axial direction, where such segregation would not normally occur. These findings, and the explanations provided of their underlying mechanisms, could lead to radical new designs for a broad range of particle processing applications but also may potentially prove useful for medical and microflow applications.

Maximizing energy transfer in vibrofluidized granular systems.

Using discrete particle simulations validated by experimental data acquired using the positron emission particle tracking technique, we study the efficiency of energy transfer from a vibrating wall to a system of discrete, macroscopic particles. We demonstrate that even for a fixed input energy from the wall, energy conveyed to the granular system under excitation may vary significantly dependent on the frequency and amplitude of the driving oscillations. We investigate the manner in which the efficiency with which energy is transferred to the system depends on the system variables and determine the key control parameters governing the optimization of this energy transfer. A mechanism capable of explaining our results is proposed, and the implications of our findings in the research field of granular dynamics as well as their possible utilization in industrial applications are discussed.

Competition between geometrically induced and density-driven segregation mechanisms in vibrofluidized granular systems.

The behaviors of granular systems are sensitive to a wide variety of particle properties, including size, density, elasticity, and shape. Differences in any of these properties between particles in a granular mixture may lead to segregation, or "demixing," a process of great industrial relevance. Despite the known influence of particle geometry in granular systems, a considerable fraction of research into these systems concerns only uniformly spherical particles. We address, for the case of vertically vibrated granular systems, the important question of whether the introduction of differing particle geometries entirely invalidates our existing knowledge based on purely spherical granulates, or whether current models may simply be adapted to account for the effects of particle shape. We demonstrate that while shape effects can indeed influence the dynamical and segregative behaviors of a granular system, the segregative mechanisms associated with particle geometry are decidedly secondary to those related to particle density. The relevant control parameters determining the extent of geometrically induced segregation are established. Finally, a manner in which shape effects may be accounted for in simulations utilizing purely spherical particles is proposed.

How consistent are the transcriptome changes associated with cold acclimation in two species of the Drosophila virilis group?

For many organisms the ability to cold acclimate with the onset of seasonal cold has major implications for their fitness. In insects, where this ability is widespread, the physiological changes associated with increased cold tolerance have been well studied. Despite this, little work has been done to trace changes in gene expression during cold acclimation that lead to an increase in cold tolerance. We used an RNA-Seq approach to investigate this in two species of the Drosophila virilis group. We found that the majority of genes that are differentially expressed during cold acclimation differ between the two species. Despite this, the biological processes associated with the differentially expressed genes were broadly similar in the two species. These included: metabolism, cell membrane composition, and circadian rhythms, which are largely consistent with previous work on cold acclimation/cold tolerance. In addition, we also found evidence of the involvement of the rhodopsin pathway in cold acclimation, a pathway that has been recently linked to thermotaxis. Interestingly, we found no evidence of differential expression of stress genes implying that long-term cold acclimation and short-term stress response may have a different physiological basis.

CMOS Active Pixel Sensors as energy-range detectors for proton Computed Tomography.

Since the first proof of concept in the early 70s, a number of technologies has been proposed to perform proton CT (pCT), as a means of mapping tissue stopping power for accurate treatment planning in proton therapy. Previous prototypes of energy-range detectors for pCT have been mainly based on the use of scintillator-based calorimeters, to measure proton residual energy after passing through the patient. However, such an approach is limited by the need for only a single proton passing through the energy-range detector in a read-out cycle. A novel approach to this problem could be the use of pixelated detectors, where the independent read-out of each pixel allows to measure simultaneously the residual energy of a number of protons in the same read-out cycle, facilitating a faster and more efficient pCT scan. This paper investigates the suitability of CMOS Active Pixel Sensors (APSs) to track individual protons as they go through a number of CMOS layers, forming an energy-range telescope. Measurements performed at the iThemba Laboratories will be presented and analysed in terms of correlation, to confirm capability of proton tracking for CMOS APSs.

Influence of thermal convection on density segregation in a vibrated binary granular system.

Using a combination of experimental results and discrete particle method simulations, the role of buoyancy-driven convection in the segregative behavior of a three-dimensional, binary granular system is investigated. A relationship between convective motion and segregation intensity is presented, and a qualitative explanation for this behavior is proposed. This study also provides an insight into the role of diffusive behavior in the segregation of a granular bed in the convective regime. The results of this work strongly imply the possibility that, for an adequately fluidized granular bed, the degree of segregation may be indirectly controlled through the adjustment of the system's driving parameters, or the dissipative properties of the system's side-boundaries.

Evidence for triangular D3h symmetry in 12C.

We report a measurement of a new high spin Jπ=5- state at 22.4(2) MeV in 12C which fits very well to the predicted (ground state) rotational band of an oblate equilateral triangular spinning top with a D3h symmetry characterized by the sequence 0+, 2+, 3-, 4±, 5- with almost degenerate 4+ and 4- (parity doublet) states. Such a D3h symmetry was observed in triatomic molecules, and it is observed here for the first time in nuclear physics. We discuss a classification of other rotation-vibration bands in 12C such as the (0+) Hoyle band and the (1-) bending mode band and suggest measurements in search of the predicted ("missing") states that may shed new light on clustering in 12C and light nuclei. In particular, the observation (or nonobservation) of the predicted ("missing") states in the Hoyle band will allow us to conclude the geometrical arrangement of the three alpha particles composing the Hoyle state at 7.654 MeV in 12C.

Center of mass scaling in three-dimensional binary granular systems.

Using a combination of experimental results acquired through positron emission particle tracking and simulational results obtained via the discrete particle method, we determine a scaling relationship for the center of mass height of a vibrofluidized three-dimensional, bidisperse granular system. We find the scaling to be dependent on the characteristic velocity with which the system is driven, the depth of the granular bed, and the elasticities of the particles involved, as well as the degree of segregation exhibited by the system and the ratio of masses between particle species. The scaling is observed to be robust over a significant range of system parameters.

Proton-counting radiography for proton therapy: a proof of principle using CMOS APS technology.

Despite the early recognition of the potential of proton imaging to assist proton therapy (Cormack 1963 J. Appl. Phys. 34 2722), the modality is still removed from clinical practice, with various approaches in development. For proton-counting radiography applications such as computed tomography (CT), the water-equivalent-path-length that each proton has travelled through an imaged object must be inferred. Typically, scintillator-based technology has been used in various energy/range telescope designs. Here we propose a very different alternative of using radiation-hard CMOS active pixel sensor technology. The ability of such a sensor to resolve the passage of individual protons in a therapy beam has not been previously shown. Here, such capability is demonstrated using a 36 MeV cyclotron beam (University of Birmingham Cyclotron, Birmingham, UK) and a 200 MeV clinical radiotherapy beam (iThemba LABS, Cape Town, SA). The feasibility of tracking individual protons through multiple CMOS layers is also demonstrated using a two-layer stack of sensors. The chief advantages of this solution are the spatial discrimination of events intrinsic to pixelated sensors, combined with the potential provision of information on both the range and residual energy of a proton. The challenges in developing a practical system are discussed.

The production of Neptunium-236g.

Radiochemical analysis of (237)Np is important in a number of fields, such as nuclear forensics, environmental analysis and measurements throughout the nuclear fuel cycle. However analysis is complicated by the lack of a stable isotope of neptunium. Although various tracers have been used, including (235)Np, (239)Np and even (236)Pu, none are entirely satisfactory. However, (236g)Np would be a better candidate for a neptunium yield tracer, as its long half-life means that it is useable as both a radiometric and mass spectrometric measurements. This radionuclide is notoriously difficult to prepare, and limited in scope. In this paper, we examine the options for the production of (236g)Np, based on work carried out at NPL since 2011. However, this work was primarily aimed at the production of (236)Pu, and not (236g)Np and therefore the rate of production are based on the levels of (236)Pu generated in the irradiation of (i) (238)U with protons, (ii) (235)U with deuterons, (iii) (236)U with protons and (iv) (236)U with deuterons. The derivation of a well-defined cross section is complicated by the relevant paucity of information on the variation of the (236m)Np:(236g)Np production ratio with incident particle energy. Furthermore, information on the purity of (236g)Np so produced is similarly sparse. Accordingly, the existing data is assessed and a plan for future work is presented.

Energy non-equipartition in strongly convective granular systems.

Using positron emission particle tracking, the effects of convective motion and the resulting segregative behaviour on the partition of kinetic energy between the components of a bidisperse granular system are, for the first time, systematically investigated. It is found that the distribution of energy between the two system components, which are equal in size but differ in their material properties, is strongly dependent on the degree of segregation observed in the granular bed. The results obtained demonstrate that the difference in energy obtained by dissimilar particle species is not an innate property of the materials in question, but can in fact be altered through variation of the relevant system parameters. The existence of a relationship between the convective and segregative properties of a granular system and the degree of energy equipartition within the system implies the possibility of extending existing theory into the convective regime. Thus, our findings represent an incremental step towards the definition of a granular analogy to temperature that can be applied to more generalised systems and, through this, an improved understanding of inhomogeneous granular systems in general.