The Challenging but Imperative Path to Monoclonal Antibody Use Against COVID-19 for a Small Overseas Military Hospital.

Upon the U.S. FDA approval in early November for a monoclonal antibody proven to potentially mitigate adverse outcomes from coronavirus disease 2019 (COVID-19) infections, our small overseas community hospital U.S. Naval Hospital Rota, Spain (USNH Rota) requested and received a limited number of doses. Concurrently, our host nation, which previously had reported the highest number of daily deaths from COVID-19, was deep within a second wave of infections, increasing hospital admissions, near intensive care unit capacity, and deaths. As USNH Rota was not normally equipped for the complex infusion center required to effectively deliver the monoclonal antibody, we coordinated a multi-directorate and multidisciplinary effort in order to set up an infusion room that could be dedicated to help with our fight against COVID. Identifying a physician team lead, with subject matter experts from nursing, pharmacy, facilities, and enlisted corpsmen, our team carefully ensured that all requisite steps were set up in advance in order to be able to identify the appropriate patients proactively and treat them safely with the infusion that has been clinically proven to decrease hospital admissions and mortality. Additional benefits included the establishment of an additional negative pressure room near our emergency room for both COVID-19 patients and, when needed, the monoclonal antibody infusion. In mid-January, a COVID-19-positive patient meeting the clinical criteria for monoclonal antibody infusion was safely administered this potentially life-saving medication, a first for small overseas hospitals. Here, we describe the preparation, challenges, obstacles, lessons learned, and successful outcomes toward effectively using the monoclonal antibody overseas.

Leadership Root Cause Analysis: Using a Formal Analysis Tool to Dissect and Promote Intrusive Leadership in a U.S. Naval Hospital.

Intrusive leadership is a method that looks for signs that might indicate a problem within or outside of the workplace that can affect a member's performance and, subsequently, the mission. Our scenario demonstrates how intrusive leadership can identify potential problems which, when coupled with accountability, can prevent more significant complications.

Ocular Injuries and Cultural Influences in Afghanistan During 5 Months of Operation Enduring Freedom.

In support of Operation Enduring Freedom, American, North American Treaty Organization (NATO) Coalition, and Afghan forces worked together in training exercises and counterinsurgency operations. While serving at the NATO Role 3 Multinational Medical Unit, Kandahar, Afghanistan, numerous patients with explosive blast injuries (Coalition and Afghan security forces, and insurgents) were treated. A disparity was noted between the ocular injury patterns of US and Coalition forces in comparison with their Afghan counterparts, which were overwhelmingly influenced by the use, or lack thereof, of eye protection. Computed tomography imaging coupled, with a correlative clinical examination, demonstrated the spectrum of ocular injuries that can result from an explosive blast. Patient examination was performed by Navy radiologists and an ophthalmologist. A cultural analysis by was performed to understand why eye protection was not used, even if available to Afghan forces, by the injured patients in hope of bridging the gap between Afghan cultural differences and proper operational risk management of combat forces.

Upper extremity overuse injuries in pediatric athletes: clinical presentation, imaging findings, and treatment.

UNLABELLED: Given the frequency and severity of overuse injuries in pediatric athletes and the potential for long-term deleterious effects, it is important for radiologists to have a comprehensive understanding of these injuries and their imaging spectrum. This article addresses chronic overuse injuries involving the upper extremity in the pediatric athlete. Chronic upper extremity overuse injuries in competitive pediatric athletes yield imaging findings that can be subtle, obvious and characteristic, or atypical. Prompt application of the appropriate imaging modalities and their accurate interpretation expedites management, returning the pediatric athlete to the playing field while minimizing long-term adverse outcomes. SUMMARY STATEMENT: Proper modality selection and interpretation in the imaging evaluation of upper extremity overuse injuries in pediatric athletes include an understanding of skeletal development, mechanism of injury, and clinical presentation to provide accurate diagnoses and mitigate long-term adverse sequelae. LEARNING OBJECTIVES: After reading this article and taking the test, the reader will be able to: • Describe the clinical presentation and imaging characteristics of a variety of pediatric overuse injuries in the upper extremity including little league shoulder, rotator cuff tendinosis, gymnast wrist, climber's finger, and myriad pathologies about the elbow. • Explain how the physis plays a crucial role in pediatric overuse injury and how to evaluate physeal injury in a multimodal approach. • Understand the clinical management for certain pediatric overuse injuries, especially those that have potential for long-term and/or permanent disability.

Imaging of Meckel's diverticulum in adults: pictorial essay.

Meckel's diverticulum is the most common congenital abnormality of the gastrointestinal tract. It is usually asymptomatic but may present with complications of acute diverticular inflammation, ulceration, hemorrhage, small bowel obstruction, perforation, retained foreign bodies, enterolith formation, and neoplasm development. Thus, the preoperative radiological diagnosis is crucial for proper management of the patients. This article reviews the anatomic and clinical features of Meckel's and describes the role of imaging in the detection of Meckel's and evaluation of its associated pathological processes.

Lower extremity overuse injuries in pediatric athletes: clinical presentation, imaging findings, and treatment.

Paralleling the growing popularity of organized sports among pediatric athletes, the stress and intensity of training regimens has escalated the frequency and severity of pediatric overuse injuries. It is essential that radiologists have a thorough knowledge of the pathogenesis of these injuries and of their characteristic patterns with different imaging techniques in order to appropriately diagnose overuse injuries in the pediatric skeleton. Knowledge of the classification, mechanism, clinical and imaging manifestations of acute and chronic overuse injuries of the lower extremities common among pediatric athletes can assist in imaging-based diagnosis and characterization of injury.

PET/CT appearance of acute pyelonephritis.

An 18-year-old male patient with a history of Ewing sarcoma originally involving the right ilium was evaluated with an FDG PET/CT scan to evaluate the effect of salvage therapy after standard treatment failed and disease progressed to involve the right T12 pedicle. Autologous stem cell transplantation and cyberknife therapy resulted in mixed tumor response, with incidental note made of prominent areas of cortical FDG avidity in the right kidney. These regions demonstrated focal hypoenhancement on the corresponding diagnostic contrast-enhanced CT, which additionally demonstrated peripheral enhancement spanning the length of the right ureter. Clinical workup produced a diagnosis of acute pyelonephritis.

Spectral Doppler signature waveforms in ultrasonography: a review of normal and abnormal waveforms.

Doppler ultrasound is routinely used in the clinical setting to evaluate blood flow in many major vessels of the body. Spectral Doppler is used to display the normal and abnormal signature waveforms that are unique to each vessel. It is important for the sonographer and the radiologist to recognize both what is normal and what is abnormal in a spectral Doppler display. In this review, we briefly explain the physics behind Doppler ultrasound and some of the most common mathematical equations applied in a routine clinical examination. We also describe and demonstrate normal versus abnormal spectral Doppler signature waveforms of vessels in the neck, abdomen, pelvis, and fetus.

Clinical and experimental applications of NIR-LED photobiomodulation.

This review presents current research on the use of far-red to near-infrared (NIR) light treatment in various in vitro and in vivo models. Low-intensity light therapy, commonly referred to as "photobiomodulation," uses light in the far-red to near-infrared region of the spectrum (630-1000 nm) and modulates numerous cellular functions. Positive effects of NIR-light-emitting diode (LED) light treatment include acceleration of wound healing, improved recovery from ischemic injury of the heart, and attenuated degeneration of injured optic nerves by improving mitochondrial energy metabolism and production. Various in vitro and in vivo models of mitochondrial dysfunction were treated with a variety of wavelengths of NIR-LED light. These studies were performed to determine the effect of NIR-LED light treatment on physiologic and pathologic processes. NIRLED light treatment stimulates the photoacceptor cytochrome c oxidase, resulting in increased energy metabolism and production. NIR-LED light treatment accelerates wound healing in ischemic rat and murine diabetic wound healing models, attenuates the retinotoxic effects of methanol-derived formic acid in rat models, and attenuates the developmental toxicity of dioxin in chicken embryos. Furthermore, NIR-LED light treatment prevents the development of oral mucositis in pediatric bone marrow transplant patients. The experimental results demonstrate that NIR-LED light treatment stimulates mitochondrial oxidative metabolism in vitro, and accelerates cell and tissue repair in vivo. NIR-LED light represents a novel, noninvasive, therapeutic intervention for the treatment of numerous diseases linked to mitochondrial dysfunction.

Cross-cultural dynamics in rural Peru.

Cross-cultural and language barriers can be an impediment to the conduct of biomedical studies in developing nations. To assess the implementation of human-use procedures within a minimum-risk febrile illness surveillance study in Peru, personnel fluent in both English and Spanish conducted a review of 10 sites. Guideline adherence, consent procedures, and potential problems in the conduct of the trial were reviewed. Concerns cited by on-site investigators included patient follow-up, poor facilities, and power fluctuations that jeopardized samples before shipment to a central location. However, both local study coordinators and patients demonstrated a clear grasp of study enrollment and consent procedures and reported no significant problems in the conduct of the study. These findings suggest that significant planning is crucial before initiation of biomedical studies in developing nations to successfully overcome physical challenges and cultural dynamics that could otherwise adversely affect scientific outcomes.

Innate immunity for biodefense: a strategy whose time has come.

Defense against biothreat agents requires a broad-spectrum approach. Modulation of the innate immune system might fulfill this requirement. Hackett's previous review of innate immune activation as a broad-spectrum biodefense strategy identified several unresolved questions. The current article is a systematic approach to answering those questions with the focused participation of research groups developing this technology. Our team of academic and industry participants reviewed the promising agents and came to the following conclusions. It is feasible to construct a biodefense platform combining synergistic agents that activate the innate immune system against a broad range of pathogens on the basis of conserved microbial components by using a nasal spray for immune activation in the respiratory and gastrointestinal tracts because these are the most likely routes of attack. It might also be possible to include agents that inhibit molecular events leading to septic shock. Innate immune-activating agents designed to activate Toll-like and other receptors will probably provide protection against the biothreat pathogen spectrum for periods ranging from 2 to 14 days for IFNs up to 26 weeks for immunomodulatory oligonucleotides. Initial treatment is proposed on the first index case or biosensor alert. Boost doses would be required. Harmful inflammation is possible, but thus far, only transient fever has been observed. Autoimmune reaction and retroviral activation have not been seen thus far in preclinical and human trials of many of these compounds. Toll-like receptor agonists caused cytokine production in all subjects tested, but genetic polymorphism reduced the response to IFN in African American subjects.