Evaluation of Scopio Labs X100 Full Field PBS: The first high-resolution full field viewing of peripheral blood specimens combined with artificial intelligence-based morphological analysis.

BACKGROUND: Current digital cell imaging systems perform peripheral blood smear (PBS) analysis in limited regions of the PBS and require the support of manual microscopy without achieving full digital microscopy. We report a multicenter study that validated the Scopio Labs X100 Full Field PBS, a novel digital imaging system that utilizes a full field view approach for cell recognition and classification, in a decision support system mode. METHODS: We analyzed 335 normal and 310 abnormal PBS from patients with various clinical conditions and compared the performance of Scopio's Full Field PBS as the test method, with manual PBS analysis as the reference method. Deming regression analysis was utilized for comparisons of WBC and platelet estimates. Measurements of WBC and platelet estimation accuracy along with the agreement on RBC morphology evaluation were performed. Reproducibility and repeatability (R&R) of the system were also evaluated. RESULTS: Scopio's Full Field PBS WBC accuracy was evaluated with an efficiency of 96.29%, sensitivity of 87.86%, and specificity of 97.62%. The agreement between the test and reference method for RBC morphology reached 99.77%, and the accuracy for platelet estimation resulted in an efficiency of 94.89%, sensitivity of 90.00%, and specificity of 96.28%, with successful R&R tests. The system enabled a comprehensive review of full field PBS as shown in representative samples. CONCLUSIONS: Scopio's Full Field PBS showed a high degree of correlation of all tested parameters with manual microscopy. The novel full field view of specimens facilitates the long-expected disengagement between the digital application and the manual microscope.

A realização do teste anti-HIV no pré-natal: os significados para a gestante / The establishment of ANTI-HIV test in pre-natal: meanings for pregnancy / El establecimiento de la lucha contra la prueba del vih en pre-navidad: significados para el embarazo

O estudo teve por objetivo conhecer e analisar o significado da realização do teste anti-HIV no pré-natal para as gestantes. Trata-se de uma pesquisa com abordagem qualitativa e foi realizada em um Hospital Escola e em uma Maternidade do município do Riode Janeiro. Como recurso técnico-metodológico utilizou-se o discurso do sujeito coletivo (DSC). Após a análise dos discursos verificamos que para as gestantes a realização do teste significa a possibilidade de prevenir a transmissão vertical do HIV e comoparte da assistência pré-natal. O pré-natal foi considerado pelas gestantes uma excelente oportunidade para a realização do teste anti HIV, para o conhecimento da condição sorológica e início precoce do tratamento. Conclui-se que o teste, para a maioria das gestantes, representa a possibilidade de proteger o filho do HIV, além de fazer parte da construção do papel materno a partir de um cuidado concreto com a saúde do bebê.

The study had as objective, the knowledge and the analyzis ofthe meaning of the accomplishment for the test anti-HIV in the prenatal one for the pregnant women. One is about a research with qualitative approach and was carried through in a HospitalSchool and a Maternity at the city of Rio de Janeiro. As a resource of technician-methodological, the speech of the collective citizen was used (DSC). After the analysis of the speeches we verifiedthat, for the pregnant women the accomplishment of the test means the possibility to prevent the vertical transmission of the HIV and as part of the prenatal assistance. The prenatal one was considered by the pregnant women an excellent chance for theaccomplishment of the test anti HIV, for the knowledge of the serological condition and precocious beginning of the treatment. It is concluded that the test, for the majority of the pregnantwomen, represents the possibility to protect the son of the HIV, beyond being part of the construction of the maternal paper from a well-taken care of concrete with the health of the baby.

El estudio que tenía para que el objetivo sepa y analice el significado de la realización del anti-VIH de la prueba en el prenatal para las mujeres embarazadas. Uno está sobre unainvestigación con acercamiento cualitativo y fue ejecutado en una escuela del hospital y una maternidad de la ciudad de Rio de Janeiro. Como recurso técnico-metodológico el discursodel ciudadano colectivo fue utilizado (DSC). Después de que el análisis de los discursos, nosotros verificamos que para las mujeres embarazadas la realización de la prueba significa laposibilidad para prevenir la transmisión vertical del VIH y como parte de la ayuda prenatal. El prenatal era considerado por las mujeres embarazadas una ocasión excelente para la realización del anti VIH de la prueba, para el conocimiento dela condición sorological y del principio precoz del tratamiento. Se concluye que la prueba, para la mayoría de las mujeres embarazadas, representa la posibilidad para proteger al hijodel VIH, más allá de ser parte de la construcción del papel maternal de un cuidado bien-tomado del concreto con la salud del bebé.