1.
J Labelled Comp Radiopharm
; 60(12): 577-585, 2017 10.
Artículo
en Inglés
| MEDLINE
| ID: mdl-28763109
RESUMEN
An 8-step preparation of 14 C-labelled CHF6001, a potent phosphodiesterase 4 inhibitor in the treatment of respiratory diseases, is described. An overall yield of approximately 9% was obtained starting from copper[14 C]cyanide. The synthesis of a stable labelled version of CHF6001 is also reported using the commercially available trideuterated bromomethylcyclopropane as starting material.