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1.
J Mater Sci Mater Med ; 24(12): 2683-93, 2013 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-23929214

RESUMEN

The aim of this study was to characterize the microstructure and mechanical properties of porous fiber-reinforced composites (FRC). Implants made of the FRC structures are intended for cranial applications. The FRC specimens were prepared by impregnating E-glass fiber sheet with non-resorbable bifunctional bis-phenyl glycidyl dimethacrylate and triethylene glycol dimethacrylate resin matrix. Four groups of porous FRC specimens were prepared with a different amount of resin matrix. Control group contained specimens of fibers, which were bound together with sizing only. Microstructure of the specimens was analyzed using a micro computed tomography (micro-CT) based method. Mechanical properties of the specimens were measured with a tensile test. The amount of resin matrix in the specimens had an effect on the microstructure. Total porosity was 59.5 % (median) in the group with the lowest resin content and 11.2 % (median) in the group with the highest resin content. In control group, total porosity was 94.2 % (median). Correlations with resin content were obtained for all micro-CT based parameters except TbPf. The tensile strength of the composites was 21.3 MPa (median) in the group with the highest resin content and 43.4 MPa (median) in the group with the highest resin content. The tensile strength in control group was 18.9 MPa (median). There were strong correlations between the tensile strength of the specimens and most of the micro-CT based parameters. This experiment suggests that porous FRC structures may have the potential for use in implants for cranial bone reconstructions, provided further relevant in vitro and in vivo tests are performed.


Asunto(s)
Vidrio/química , Resinas Compuestas/química , Humanos , Ensayo de Materiales , Metacrilatos/química , Microscopía Electrónica de Rastreo , Polietilenglicoles/química , Polímeros/química , Ácidos Polimetacrílicos/química , Porosidad , Prótesis e Implantes , Cráneo/química , Cráneo/diagnóstico por imagen , Estrés Mecánico , Resistencia a la Tracción , Microtomografía por Rayos X
2.
Eur Arch Otorhinolaryngol ; 269(2): 623-8, 2012 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-21630063

RESUMEN

Bioactive glass (BAG) and polymethyl methacrylate (PMMA) have been used in clinical applications. Antimicrobial BAG has the ability to attach chemically to surrounding bone, but it is not possible to bend, drill or shape BAG during the operation. PMMA has advantages in terms of shaping during the operation, but it does not attach chemically to the bone and is an exothermic material. To increase the usefulness of BAG and PMMA in skull bone defect reconstructions, a new composite implant containing BAG and PMMA in craniofacial reconstructions is presented. Three patients had pre-existing large defects in the calvarial and one in the midface area. An additive manufacturing (AM) model was used preoperatively for treatment planning and custom-made implant production. The trunk of the PMMA implant was coated with BAG granules. Clinical and radiological follow-up was performed postoperatively at 1 week, and 3, 6 and 12 months, and thereafter annually up to 5 years. Computer tomography (CT) and positron emission tomography (PET-CT) were performed at 12 and 24 months postoperatively. Uneventful clinical recovery with good esthetic and functional outcome was seen. CT and PET-CT findings supported good clinical outcome. The BAG-PMMA implant seems to be a promising craniofacial reconstruction alternative. However, more clinical experience is needed.


Asunto(s)
Materiales Biocompatibles , Sustitutos de Huesos , Craneotomía/métodos , Vidrio , Procedimientos de Cirugía Plástica/métodos , Polimetil Metacrilato , Implantación de Prótesis/métodos , Fracturas Craneales/cirugía , Cráneo/cirugía , Adulto , Anciano , Fluorodesoxiglucosa F18 , Estudios de Seguimiento , Humanos , Procesamiento de Imagen Asistido por Computador , Imagenología Tridimensional , Masculino , Persona de Mediana Edad , Imagen Multimodal , Oseointegración/fisiología , Tomografía de Emisión de Positrones , Complicaciones Posoperatorias/diagnóstico por imagen , Diseño de Prótesis , Ajuste de Prótesis , Propiedades de Superficie , Tomografía Computarizada por Rayos X , Adulto Joven
3.
Int J Biomater ; 2009: 765813, 2009.
Artículo en Inglés | MEDLINE | ID: mdl-20130804

RESUMEN

The purpose of this study was to evaluate bacterial adhesion and early colonization on a composite consisting of bioactive glass (BAG) particles and copolymer of epsilon-caprolactone/D,L-lactide. Materials were incubated with suspensions of both type strains and clinical isolates of Streptococcus pneumoniae, Haemophilus influenzae, and Pseudomonas aeruginosa for 30 minutes (adhesion) and 4 hours (colonization). Clear differences exist in the microorganisms' ability to adhere on the experimental materials. However, the presence of BAG particles does not inhibit bacterial adhesion, but early colonization of the materials with P. aeruginosa was inhibited by the addition of 90-315 mum BAG particles.

5.
J Oral Maxillofac Surg ; 66(4): 639-46, 2008 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-18355587

RESUMEN

PURPOSE: Synthetic bioactive glass (BAG) is used in many surgical applications. Special bioactive glasses do not favor microbial growth. This study evaluated the clinical outcome of bioactive glass plates in reconstructive orbital surgery. PATIENTS AND METHODS: In a retrospective series of 49 patients, 35 orbital floors and 6 orbital medial and superior walls were reconstructed after fronto-orbital trauma, and 8 patients were treated with BAG plates after fronto-orbital tumor resection. These patients were evaluated in terms of reconstruction materials, complications, and functional outcomes. RESULTS: During the 2-year follow-up, 3 of the 35 orbital floor trauma reconstructions were reoperated (9%) because of diplopia, and new reconstructions with BAG were performed. In all of the 8 patients with tumors and in 6 of the patients undergoing orbital wall reconstruction, the plates were in the correct position after reconstruction, and none had to be removed. One patient with a benign tumor and 7 of the 8 patients with malignant tumors survived to the 2-year follow-up. CONCLUSIONS: Reconstructive surgery of the orbit is one of the most demanding challenges in head and neck surgery. In orbital defect reconstruction, a BAG plate seems to be a well-tolerated and reliable reconstruction material alternative; however, BAG plates are brittle and rigid, and cannot be molded and shaped by a surgeon. The use of a stainless steel template of equal shape and size to a BAG plate is recommended to ameliorate this deficiency.


Asunto(s)
Sustitutos de Huesos , Fijación Interna de Fracturas/métodos , Vidrio , Órbita/cirugía , Fracturas Orbitales/cirugía , Implantes Orbitales , Neoplasias Orbitales/cirugía , Adolescente , Adulto , Anciano , Placas Óseas , Femenino , Fijación Interna de Fracturas/instrumentación , Humanos , Masculino , Persona de Mediana Edad , Estudios Retrospectivos
6.
J Biomed Mater Res B Appl Biomater ; 84(2): 510-9, 2008 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-17618510

RESUMEN

UNLABELLED: The aim of this study was to evaluate glass-fiber-reinforced composite as a bone reconstruction material in the critical size defects in rabbit calvarial bones. The bone defect healing process and inflammatory reactions were evaluated histologically at 4 and 12 weeks postoperatively. Possible neuropathological effects on brain tissue were evaluated. The release of residual monomers from the fiber-reinforced composite (FRC) was analyzed by high performance liquid chromatograph (HPLC). RESULTS: At 4 weeks postoperatively, fibrous connective tissue ingrowth to implant structures was seen. Healing had started as new bone formation from defect margins, as well as woven bone islets in the middle of the defect. Woven bone was also seen inside the implant. Inflammation reaction was slight. At 12 weeks, part of the new bone had matured to lamellar-type, and inflammation reaction was slight to moderate. Control defects had healed by fibrous connective tissue. Histological examinations of the brain revealed no obvious damage to brain morphology. In HPLC analysis, the release of residual 1,4-butanedioldimethacrylate and methylmethacrylate from polymerized FRC was low. CONCLUSIONS: This FRC-implant was shown to promote the healing process of critical size calvarial bone defect in rabbits. After some modifications to the material properties, this type of implant has the potential to become an alternative for the reconstruction of bone defects in the head and neck area in the future.


Asunto(s)
Sustitutos de Huesos , Materiales Biocompatibles Revestidos , Resinas Compuestas , Vidrio , Cráneo/cirugía , Animales , Butileno Glicoles , Dendrímeros , Metilmetacrilato , Proyectos Piloto , Conejos , Cráneo/lesiones
7.
Plast Reconstr Surg ; 120(7): 1963-1972, 2007 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-18090760

RESUMEN

BACKGROUND: Synthetic bioactive ceramics and glasses have osteoconductive properties. These materials are capable of chemically bonding to the bone tissue. In addition, special bioactive glasses do not favor microbial growth. In this study, the clinical outcome of bioactive glass and hydroxyapatite in head and neck surgery was evaluated. METHODS: In a retrospective series of 150 patients, 62 patients underwent reconstruction with frontal sinus obliteration after chronic frontal sinusitis, 65 patients were operated on for fronto-orbital traumas, and 23 patients underwent reconstruction after fronto-orbital tumor resections. These patients were evaluated for surgical procedures, reconstruction materials, complications, and functional outcomes. RESULTS: Three of the 62 frontal sinus occlusions underwent operation (4.8 percent) during the follow-up of 5 years. The reoperations were caused by a new mucocele. In fronto-orbital reconstructions, we have reoperated on the orbital floor in four cases (7 percent). All 12 benign tumor patients and six of 11 malignant tumor patients survived during a follow-up of 3 years. Two of the 23 (9 percent) complicated tumor and trauma patients underwent reoperation because of a local mucocele. CONCLUSIONS: Treatment of severe head and neck defects with biomaterial is a suitable alternative to conventional methods. Bioactive materials seem to be stable and reliable at clinical follow-up. The reconstructions with bioactive glass and hydroxyapatite are associated with good functional and aesthetic results without donor-site morbidity. However, more long-term outcomes of studied biomaterials are needed to determine whether they are capable of competing with traditional tissue grafts.


Asunto(s)
Sustitutos de Huesos , Durapatita , Hueso Frontal/cirugía , Vidrio , Órbita/cirugía , Procedimientos de Cirugía Plástica/instrumentación , Adolescente , Adulto , Anciano , Niño , Femenino , Hueso Frontal/lesiones , Seno Frontal/cirugía , Sinusitis Frontal/cirugía , Humanos , Masculino , Ensayo de Materiales , Persona de Mediana Edad , Mucocele/cirugía , Neoplasias Orbitales/cirugía , Recurrencia , Estudios Retrospectivos , Neoplasias Craneales/cirugía
8.
Dig Dis Sci ; 52(7): 1678-84, 2007 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-17385028

RESUMEN

Normal values of extra-esophageal reflux are difficult to determine owing to variation in the location of the proximal electrode, limited information on the ingestion of acidic food, different exclusion periods for meals, and poor reproducibility of measurement of extra-esophageal reflux. We studied whether ambulatory esophageal pH testing is disturbed by acidic food ingestion. Eighteen healthy subjects were enrolled in standard dual-channel esophageal pH tests (recorder 1). Ten subjects were equipped with another pH device (recorder 2), positioned to measure extra-esophageal reflux. The subjects were exposed to controlled ingestion of different acidic food or liquid for five 1-min periods. The present study showed that acidic food ingestion for 5 min has a significant effect on the outcome of standard dual-channel ambulatory pH testing. Reflux occurs equally on proximal channels during ingestion of acidic food, whether the proximal channel position is normal or 2 cm above the upper esophageal sphincter. We recommend avoiding acidic food intake during esophageal pH testing.


Asunto(s)
Bebidas , Monitorización del pH Esofágico/normas , Alimentos , Reflujo Gastroesofágico/diagnóstico , Adulto , Reacciones Falso Positivas , Femenino , Humanos , Concentración de Iones de Hidrógeno , Masculino , Factores de Tiempo
9.
Head Neck ; 28(9): 834-41, 2006 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-16823870

RESUMEN

BACKGROUND: Synthetic, osteoconductive, and antimicrobial bioactive glass (BAG) has been used in many surgical applications. METHODS: BAG was used as obliteration material in a series of osteoplastic frontal sinus operations on 42 patients suffering from chronic frontal sinusitis, which could not be cured with other means of treatment. RESULTS: Accurate obliteration of sinuses was achieved in 39 patients. Uneventful recovery and clinical outcome were seen in 92% of the patients. Histopathologic samples harvested at 1, 5, and 10 years after obliteration revealed a healing process progressing from the fibrous tissue phase to bone formation with scattered fibrous tissue and bony obliteration maintaining BAG granule remnants. Fourier-transform infrared (FTIR) studies showed bone produced by BAG to be similar to natural frontal bone. Micorobiologic cultures obtained with histologic samples revealed no growth of bacteria. CONCLUSIONS: BAG appears to be a reliable frontal sinus obliteration material, providing favorable conditions for total bony sinus obliteration.


Asunto(s)
Seno Frontal/cirugía , Sinusitis Frontal/cirugía , Vidrio , Adulto , Anciano , Femenino , Estudios de Seguimiento , Hueso Frontal/crecimiento & desarrollo , Seno Frontal/diagnóstico por imagen , Seno Frontal/patología , Sinusitis Frontal/diagnóstico por imagen , Sinusitis Frontal/patología , Humanos , Masculino , Persona de Mediana Edad , Tomografía Computarizada por Rayos X
11.
J Biomed Mater Res B Appl Biomater ; 66(1): 364-72, 2003 Jul 15.
Artículo en Inglés | MEDLINE | ID: mdl-12808596

RESUMEN

Three synthetic bioactive materials were studied in an experimental model to compare their usability in a frontal sinus and a skull bone defect obliteration. Bioactive glass number 9 (BAG(1)), bioactive glass number 13 (BAG(2)), and hydroxyapatite (HA) granules were investigated. BAG(1) and HA granules have been previously tested clinically. The clinical usefulness of BAG(2) granules has not been tested. Upper bony walls of 45 Elco rabbits' frontal sinuses were drilled open from four separate holes with the use of a standard method. The skull bone defects and the sinuses in frontal bone were filled with BAG(1) or BAG(2) on one side, and with HA on the other side. Two parallel posterior defects were covered with a pedicled periosteum flap, and two anterior defects with a free flap. The resorption of materials, new bone, and fibrous-tissue formation were observed with a histomorphometric method at 1, 3, and 6 months postoperatively. Scanning-electron microscopy (SEM) and Fourier-transform infrared spectroscopy (FTIR) were done at 6 months. In histomorphometry, the new bone formation increased with all the investigated materials throughout the study (p < 0.001), but the results showed higher new bone formation in the defects filled with BAG(1) than in corresponding BAG(2)- or HA- filled defects. New bone formation and resorption of materials were faster in defects covered by pedicled than by free periosteum flaps (p < 0.001). Intimate contact between the used materials and new bone was confirmed by SEM. FTIR analysis of bone produced by BAG(1) and BAG(2) was of the same type as natural frontal bone. BAG(2) can be manufactured in various shapes, and thus, could possibly be used in clinical conditions requiring a special anatomical implant shape. However, more research is needed regarding this property of BAG(2).


Asunto(s)
Materiales Biocompatibles , Sustitutos de Huesos , Seno Frontal/cirugía , Cráneo/cirugía , Animales , Durapatita , Vidrio , Masculino , Ensayo de Materiales , Microscopía Electrónica de Rastreo , Conejos
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