1.
Cell Metab
; 36(3): 461-462, 2024 03 05.
Artículo
en Inglés
| MEDLINE
| ID: mdl-38447528
RESUMEN
Cancer metabolism produces large fluxes of lactate and H+, which are extruded by membrane transporters. However, H+ production and extrusion must be coupled by diffusion, facilitated by mobile buffers. Yan et al. propose that carnosine, generated by CARNS2, provides this mobile buffering and enables lysosomal functions that block T cell surveillance.