1.
Bioorg Med Chem Lett
; 27(15): 3294-3300, 2017 08 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-28633899
RESUMEN
The synthesis, structure-activity relationship (SAR) data, and further optimization of the metabolic stability and pharmacokinetic (PK) properties for a previously disclosed class of cyclopropyl-fused indolobenzazepine HCV NS5B polymerase inhibitors are described. These efforts led to the discovery of BMS-961955 as a viable contingency backup to beclabuvir which was recently approved in Japan for the treatment of HCV as part of a three drug, single pill combination marketed as XimencyTM.