RESUMEN
Effective ways to reduce sedentary behaviour in adolescents are needed to mitigate the risk of chronic disease and poor mental health. Organised sport participation is the most practiced physical activity during adolescence. However, the influence sport participation has on sedentary behaviours remains unclear. This study investigated the associations between sport participation, total and domain-specific sedentary behaviour and physical activity during the transition from secondary school to university. A 3-year longitudinal survey followed Spanish secondary school students (n = 113) to their first year of university. Generalized linear models, adjusted by gender and year, assessed the relationships between sport participation, total and domain-specific sedentary behaviour and physical activity. Compared with non-sport participants, teenagers who played individual sports from baseline during secondary school spent significantly less total time sitting (- 110.5 min/day at weekends), watching television (- 18.7 min/day at weekends) or using the computer for leisure (- 37.4 min/day weekdays). Those who played team sports from baseline at secondary school spent less time sitting (- 126.4 min/day at weekends) or socialising (- 37 min/day at weekends)Conclusion: From secondary school to university, sport participation-based interventions might be an effective strategy to reduce sitting time spent on some domain-specific behaviours. Promoting sports could reduce the rise of sedentary behaviour during adolescence, a stage where sedentary behaviour evolves. What is Known: ⢠Sitting too much and for too long is an important risk factor during adolescence. ⢠Replacing adolescent's sedentary time with moderate-to-vigorous physical activity has been associated with a better quality of life. What is New: ⢠Playing sport is associated with spending less time in total SB on the transition from high school to college. ⢠Not all SB domains are linked to sport participation with associations differing from whether participants played individual or team sports.
Asunto(s)
Conducta Sedentaria , Universidades , Adolescente , Humanos , Calidad de Vida , Instituciones Académicas , EstudiantesRESUMEN
In ecology and evolution, entropic methods are now used widely and increasingly frequently. Their use can be traced back to Ramon Margalef's first attempt 70 years ago to use log-series to quantify ecological diversity, including searching for ecologically meaningful groupings within a large assemblage, which we now call the gamma level. The same year, Shannon and Weaver published a generally accessible form of Shannon's work on information theory, including the measure that we now call Shannon-Wiener entropy. Margalef seized on that measure and soon proposed that ecologists should use the Shannon-Weiner index to evaluate diversity, including assessing local (alpha) diversity and differentiation between localities (beta). He also discussed relating this measure to environmental variables and ecosystem processes such as succession. Over the subsequent decades, he enthusiastically expanded upon his initial suggestions. Finally, 2019 also would have been Margalef's 100th birthday.
RESUMEN
HLA-B*44:203 shows one nucleotide difference to B*44:03:01 at codon 171 (TAC>CAC, Y171>H171).
Asunto(s)
Alelos , Sustitución de Aminoácidos , Antígenos HLA-B/genética , Polimorfismo de Nucleótido Simple , Secuencia de Bases , Codón , Exones , Sangre Fetal/química , Sangre Fetal/inmunología , Antígenos HLA-B/clasificación , Antígenos HLA-B/inmunología , Prueba de Histocompatibilidad , Humanos , Datos de Secuencia Molecular , Isoformas de Proteínas/clasificación , Isoformas de Proteínas/genética , Isoformas de Proteínas/inmunología , Alineación de Secuencia , EspañaRESUMEN
HLA-B*08:108 shows one nucleotide difference regarding B*08:01:01 at codon 109 (CTC>TTC, L109>F109).
Asunto(s)
Alelos , Exones , Antígeno HLA-B8/genética , Polimorfismo de Nucleótido Simple , Secuencia de Bases , Trasplante de Médula Ósea , Codón , Antígeno HLA-B8/inmunología , Prueba de Histocompatibilidad , Humanos , Datos de Secuencia Molecular , Alineación de Secuencia , Análisis de Secuencia de ADN , Donantes de Tejidos , Población BlancaRESUMEN
Two novels alleles, HLA-A*01:128 and HLA-C*05:88 are characterized.
Asunto(s)
Alelos , Antígenos HLA-A/genética , Antígenos HLA-C/genética , Secuencia de Aminoácidos , Sustitución de Aminoácidos , Trasplante de Médula Ósea , Codón , Antígenos HLA-A/inmunología , Antígenos HLA-C/inmunología , Prueba de Histocompatibilidad , Humanos , Datos de Secuencia Molecular , Mutación , Alineación de Secuencia , Análisis de Secuencia de ADN , España , Donantes de TejidosRESUMEN
Two novel HLA-B alleles were characterized. HLA-B*37:34 shows two nucleotide differences regarding B*37:10 at codons 79 (CGC>CGG) and 80 (ACC>ATC), resulting in one amino acid replacement at position 80 (T>I). HLA-B*44:152 differs from B*44:02:01 in one nucleotide at codon 81 (GCG>ACG) giving rise to a leucine to threonine substitution at position 81.
Asunto(s)
Antígeno HLA-B37/genética , Antígeno HLA-B44/genética , Alelos , Secuencia de Aminoácidos , Sustitución de Aminoácidos , Técnicas de Genotipaje , Prueba de Histocompatibilidad , Humanos , Datos de Secuencia Molecular , Mutación Puntual , Polimorfismo de Nucleótido Simple , Homología de Secuencia de AminoácidoRESUMEN
A*33:49 has one nucleotide change regarding A*33:01:01 at exon 3, producing an amino acid replacement at codon 97, M97 to I97.
Asunto(s)
Alelos , Exones/genética , Antígenos HLA-A/genética , Secuencia de Aminoácidos , Sustitución de Aminoácidos/genética , Presentación de Antígeno/genética , Trasplante de Células Madre de Sangre del Cordón Umbilical , Prueba de Histocompatibilidad , Humanos , Inmunidad/genética , Datos de Secuencia Molecular , Mutación/genética , Polimorfismo de Nucleótido Simple , Análisis de Secuencia de ADN , EspañaRESUMEN
DRB1*04:98 shows four nucleotide changes regarding DRB1*04:01:01, resulting in two amino acids replacement at positions A73G and A74R.
Asunto(s)
Alelos , Sustitución de Aminoácidos , Cadenas HLA-DRB1/genética , Mutación , Análisis Mutacional de ADN , Humanos , EspañaAsunto(s)
Antígenos CD34/inmunología , Antígenos/inmunología , Células Dendríticas/inmunología , Leucemia Bifenotípica Aguda/inmunología , Proteoglicanos/inmunología , Línea Celular Tumoral , Citometría de Flujo , N-Metiltransferasa de Histona-Lisina , Humanos , Inmunofenotipificación , Leucemia Bifenotípica Aguda/patología , Proteína de la Leucemia Mieloide-Linfoide/genéticaRESUMEN
Human leukocyte antigen (HLA) class I sequencing typing of a cord blood unit obtained from an Ecuadorian family showed the presence of the recently described A*6836 and B*3922 alleles. Sequences of these two antigens were confirmed and completed. Additionally, a new HLA-B allele, B*3579, was found in the same family, showing a difference of one amino acid residue at position 211 (Ala > Glu) compared with B*3543.
Asunto(s)
Alelos , Antígenos HLA-A/genética , Antígeno HLA-B35/genética , Análisis de Secuencia de ADN , Adulto , Secuencia de Aminoácidos , Secuencia de Bases , Ecuador , Femenino , Humanos , Recién Nacido , Datos de Secuencia MolecularRESUMEN
HLA-B*4077 differs from B*400101, B*4036, and B*401401 in five, four, and three nucleotides, respectively. However, amino acid alignment would indicate a closer relationship with B*4036 allele, showing a single amino acid replacement at codon 131 (R>S).
Asunto(s)
Alelos , Antígenos HLA-B/genética , Adulto , Secuencia de Bases , Humanos , Datos de Secuencia Molecular , Mutación Puntual , Polimorfismo de Nucleótido SimpleRESUMEN
HLA-B*9523 differs from B*1591 and B*1503 in point nucleotide mutations at codon 167 (TCG --> TGG) and 152 (GAG --> GTG), respectively.
Asunto(s)
Antígenos HLA-B/genética , Alelos , Secuencia de Bases , ADN/genética , Sangre Fetal/inmunología , Humanos , Recién Nacido , Datos de Secuencia Molecular , Polimorfismo Genético , Homología de Secuencia de Ácido Nucleico , España , Población Blanca/genéticaRESUMEN
DRB1*1375 differs from DRB1*1304 allele in a point nucleotide mutation at codon 67 (ATC-->TTC), which produces an amino acid residue change from I to F.
Asunto(s)
Antígenos HLA-DR/genética , Alelos , Secuencia de Aminoácidos , Secuencia de Bases , Cadenas HLA-DRB1 , Humanos , Leucocitos/inmunología , Datos de Secuencia MolecularAsunto(s)
Sangre Fetal , Trasplante de Células Madre Hematopoyéticas , Adulto , Femenino , Humanos , Recién Nacido , Masculino , EmbarazoRESUMEN
The development of the human umbilical cord blood transplants with hematopoietic repopulating cells has enabled some problems associated with bone marrow transplants to be solved. Frozen umbilical cord blood banks should facilitate the finding of suitable stem cell donors. However, further experience is necessary to develop the optimal method for collection, separation, storage and cryopreservation of umbilical cord blood. We report our experience in the organization of a Cord Blood Bank.