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CONTEXT: Pancreatic neuroendocrine tumours (PanNETs) are rare pancreatic neoplasms. PanNETs can be treated by multimodal approach including surgery, locoregional and systemic therapy. OBJECTIVE: The aim of the present study is to evaluate predictive factors of overall survival in patients with PanNETs surgically treated at a single center. SUBJECTS AND METHODS: The study group consisted of 120 patients with PanNETs who had undergone surgery at the Center of Digestive Diseases and Liver Transplantation of Fundeni Clinical Institute, Bucharest, Romania. Surgical resection of the primary tumor was performed in 110 patients. RESULTS: Tumor size > 2 cm (p=0.048) (90% CI) lymph node involvement (p=0.048), ENET grade (p<0.001), distant metastases (p<0.001), Ki 67 index (<2%, 2-5%, 5-10%, 10-20%, >20%) (p<0.001) were identified as significant prognostic factors for OS on univariate analysis. Using multivariate Cox proportional regression model we found that distant metastases and Ki 67 index were independent risk factors for the survival outcome. CONCLUSIONS: Surgery with curative intent should be considered in all cases if clinically appropriate and technically feasible. High grade (Ki67 index ≥10%) tumours were associated with a 2- fold increase in risk of death as compared to those with a Ki67 <10%.
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BACKGROUND/AIMS: Surgery remains a mainstay of current approaches for the treatment of gastric cancer. Since the introduction of the first mechanical stapling devices, a debate started about whether mechanical staplers or manual suture produce better results. METHODS: 88 patients operated by a single team between January 2004 and November 2011 were included in this study: 14 patients underwent minimally invasive total gastrectomy and 74 patients had an open total gastrectomy. Manual suture anastomoses were performed on 59 patients and stapled anastomoses were done on 29 patients. RESULTS: There were no cases of anastomotic leakage or stenosis for the stapled group. There were 4 cases of anastomotic leakage in the manually suture group. There were no cases of anastomosis related mortality. CONCLUSION: the data support the use of stapled esophagojejunal anastomosis as a safe way to create a esophagojejunal anastomosis, with superior results in term of anastomotic leakage or stenosis to those with hand suturing.