Urban public health spatial planning using big data technology and visual communication in IoT.

The planning of urban public health spatial can not only help people's physical and mental health but also help to optimize and protect the urban environment. It is of great significance to study the planning methods of urban public health spatial. The application effect of traditional urban public health spatial planning is poor, in this paper, urban public health spatial planning using big data technology and visual communication in the Internet of Things (IoT) is proposed. First, the urban public health spatial planning architecture is established in IoT, which is divided into the perception layer, the network layer and the application layer; Second, information collection is performed at the perception layer, and big data technology is used at the network layer to simplify spatial model information, automatically sort out spatial data, and establish a public health space evaluation system according to the type and characteristics of spatial data; Finally, the urban public health space is planned based on the health assessment results and the visual communication design concept through the application layer. The results show that when the number of regions reaches 60,000, the maximum time of region merging is 7.86s. The percentage of spatial fitting error is 0.17. The height error of spatial model is 0.31m. The average deviation error of the spatial coordinates is 0.23, which can realize the health planning of different public spaces.

CircASH2L facilitates tumor-like biologic behaviours and inflammation of fibroblast-like synoviocytes via miR-129-5p/HIPK2 axis in rheumatoid arthritis.

BACKGROUND: Previous study showed that circular RNA Absent-Small-Homeotic-2--Like protein (circASH2L) was higher in rheumatoid arthritis (RA) patients. However, the roles and mechanisms of circASH2L in RA progression remain unclear. METHODS: Levels analysis was conducted using western blot and qRT-PCR. The proliferation, apoptosis, cell cycle progression, migration, invasiveness, and inflammation of RA fibroblast-like synoviocytes (RA-FLSs) were determined via MTT, flow cytometry, western blot, transwell, and ELISA assays. RESULTS: CircASH2L knockdown in RA-FLSs suppressed cell proliferative, migratory, and invasive capacities, triggered cell cycle arrest, promoted apoptosis, and inhibited inflammation. Mechanistically, circASH2L targeted miR-129-5p, and repression of miR-129-5p abolished the functions of circASH2L silencing on the growth, motility, and inflammation of RA-FLSs. Besides, miR-129-5p was found to directly target HIPK2, and suppressed the tumor-like biologic behaviors and inflammation of RA-FLSs via regulating HIPK2. Importantly, we proved that circASH2L could modulate HIPK2 expression via miR-129-5p. CONCLUSION: CircASH2L promoted RA-FLS growth, motility, and inflammation through miR-129-5p/HIPK2 axis.