RESUMEN
BACKGROUND: Missed abortions are a common problem, often caused by thrombophilia in both recurring and non-recurring cases. AIM: To determine whether the presence of a mutation in the methyltetrahydrofolate reductase (Mthfr) gene correlates with missed abortions. PATIENTS AND METHODS: We selected two hundred patients for this study in two groups: the study group, which consisted of one hundred patients with a history of missed abortion; and the control group, which consisted of one hundred patients with no history of missed abortion. RESULTS: Of the 200 patients, mutations in Mthfr were only found in forty-four patients-thirty-four from the study group and ten from the control group. CONCLUSIONS: Mthfr gene mutation is a common cause of both recurring and non-recurring missed abortions.
RESUMEN
Gestational trophoblastic disease spectrum ranges from benign hydatidiform mole to trophoblastic malignancy (placental site trophoblastic tumor and choriocarcinoma). Benign gestational trophoblastic disease occurs in women of reproductive age and is extremely rare in postmenopausal women. We describe a case of complete vesicular mole in a 55-year-old postmenopausal woman complaining of postmenopausal bleeding. To our knowledge, our case represents one of the rare descriptions in the world literature of a benign complete hydatidiform mole in a postmenopausal woman.
RESUMEN
OBJECTIVES: Persistent infection with high-risk (HR) human papillomavirus (HPV) is associated with premalignant lesions and cervical cancer, the third most common cancer amongst women globally and the second most frequent in Egypt. We studied the prevalence and type distribution of HPV and documented HPV infection awareness and health-related behaviours for HPV infection. METHODS: This was a multicenter, hospital-based observational study of women ≥18 years of age who attended for a gynaecological examination during October 2010-August 2011. Cervical samples were tested using Linear Array HPV genotyping. Two questionnaires on awareness and health-related behaviour were completed. RESULTS: Four hundred and forty-three women with a mean age of 39.3±14.0 years were included in the analysis. HPV DNA was detected in 10.4% of women; a single HPV-type infection was found in 6.5% and multiple infections in 3.8%. The most prevalent HR types among HPV-positive women were HPV-16 (19.6%) and HPV-31 and HPV-51 (15.2% each); low-risk types included HPV-62 (17.4%) and HPV-84 (10.9%). The prevalence of HPV-18 was low (6.5%). The prevalence of any HR HPV-type was highest in women aged 45-54 years (9.2%). CONCLUSIONS: The overall prevalence of HPV in Egypt was 10.4% and was highest (9.2%) amongst women aged 45-54 years. These data provide important reference information for public health authorities considering HPV prevention in Egypt.