Partially coherent conical refraction promises new counter-intuitive phenomena.

In this paper, we extend the paraxial conical refraction model to the case of the partially coherent light using the unified optical coherence theory. We demonstrate the decomposition of conical refraction correlation functions into well-known conical refraction coherent modes for a Gaussian Schell-model source. Assuming randomness of the electrical field phase of the input beam, we reformulated and significantly simplified the rigorous conical refraction theory. This approach allows us to consider the propagation of light through a conical refraction crystal in exactly the same way as in the classical case of coherent radiation. Having this in hand, we derive analytically the conical refraction intensity both in the focal plane and in the far field, which allows us to explain and rigorously justify earlier experimental findings and predict new phenomena. The last include the counterintuitive effect of narrowing of the conical refraction ring width, disappearance of the dark Poggendorff's ring in the Lloyd's plane, and shift of Raman spots for the low-coherent conical refraction light. We also demonstrate a universal power-law dependence of conical refraction cones coherence degree on the input correlation length and diffraction-free propagation of the low-coherent conical refraction light in the far field.

Close relationship between Bessel-Gaussian and conical refraction beams.

We demonstrate that the conical refraction of the input elegant Laguerre-Gaussian beams can be effectively described through generalized Bessel-Gaussian light beams. We performed numerical simulations and show good agreement between the exact solution and our proposed Bessel-Gaussian approximation model. Physical clarity of the proposed model has allowed us to explain the transition of the classical double-ring pattern of conical refraction in the Lloyd plane into a multi-ring one and predict new phenomenon such as the Raman spot shift and dependence of the conical refraction ring radius on the value of the orbital angular momentum.

Development of two-photon polymerised scaffolds for optical interrogation and neurite guidance of human iPSC-derived cortical neuronal networks.

Recent progress in the field of human induced pluripotent stem cells (iPSCs) has led to the efficient production of human neuronal cell models for in vitro study. This has the potential to enable the understanding of live human cellular and network function which is otherwise not possible. However, a major challenge is the generation of reproducible neural networks together with the ability to interrogate and record at the single cell level. A promising aid is the use of biomaterial scaffolds that would enable the development and guidance of neuronal networks in physiologically relevant architectures and dimensionality. The optimal scaffold material would need to be precisely fabricated with submicron resolution, be optically transparent, and biocompatible. Two-photon polymerisation (2PP) enables precise microfabrication of three-dimensional structures. In this study, we report the identification of two biomaterials that support the growth and differentiation of human iPSC-derived neural progenitors into functional neuronal networks. Furthermore, these materials can be patterned to induce alignment of neuronal processes and enable the optical interrogation of individual cells. 2PP scaffolds with tailored topographies therefore provide an effective method of producing defined in vitro human neural networks for application in influencing neurite guidance and complex network activity.

Conical refraction mode of an optical resonator.

The fundamental mode of a conical refraction resonator, i.e., an optical cavity where light experiences conical refraction (CR) from a biaxial crystal, is experimentally demonstrated in the plano-concave cavity configuration. We have discovered that the fundamental CR mode is characterized by the polarization and intensity structures of CR beams between the plane mirror and CR crystal, and it resembles the fundamental Gaussian mode with homogeneous polarization between the crystal and concave mirror. We theoretically explained this fundamental CR mode using the dual cone model and symmetry of the CR phenomenon and confirmed this explanation by numerical simulations.

Conical refraction with low-coherence light sources.

We report on conical refraction (CR) with low-coherence light sources, such as light-emitting diodes and decoherentized HeNe laser radiation, and demonstrate different CR patterns. In our experiments, a variation of the pinhole sizes from 25 to 100 µm and the distances to pinhole from 50 to 5 cm reduced spatial coherence of radiation that resulted in the disappearance of the dark Poggendorff's ring in the Lloyd's plane. This is attributed to the interference nature of the Lloyd's distribution and found to be in excellent agreement with the paraxial dual-cone model of conical refraction.

Conical refraction output from a Nd:YVO4 laser with an intracavity conerefringent element.

A conical refraction (CR) laser based on an a-cut Nd:YVO4 laser was demonstrated. By using a KGW crystal as a CR element, a typical laser with a Gaussian intensity output profile was transformed into a laser with conically refracted output. The CR laser delivered 220 mW of output power for 500 mW of pump power. The separation of the laser gain medium and the CR element reduced the complexity of the pumping scheme, and resulted in the generation of well-behaved CR laser beams with outstanding quality. The presented approach is power scalable and offers a unique possibility of studying the transformation of a Gaussian laser mode into a conically refracted one in a laser cavity.

Slow passage through thresholds in quantum dot lasers.

A turn on of a quantum dot (QD) semiconductor laser simultaneously operating at the ground state (GS) and excited state (ES) is investigated both experimentally and theoretically. We find experimentally that the slow passage through the two successive laser thresholds may lead to significant delays in the GS and ES turn ons. The difference between the turn-on times is measured as a function of the pump rate of change ɛ and reveals no clear power law. This has motivated a detailed analysis of rate equations appropriate for two-state lasing QD lasers. We find that the effective time of the GS turn on follows an ɛ^{-1/2} power law provided that the rate of change is not too small. The effective time of the ES transition follows an ɛ^{-1} power law, but its first order correction in ln(ɛ) is numerically significant. The two turn ons result from different physical mechanisms. The delay of the GS transition strongly depends on the slow growth of the dot population, whereas the ES transition only depends on the time needed to leave a repellent steady state.

Quantum-dot saturable absorber and Kerr-lens mode-locked Yb:KGW laser with >450 kW of peak power.

The hybrid action of quantum-dot saturable absorber and Kerr-lens mode locking in a diode-pumped Yb:KGW laser was demonstrated. Using a quantum-dot saturable absorber with a 0.7% (0.5%) modulation depth, the mode-locked laser delivered 90 fs (93 fs) pulses with 3.2 W (2.9 W) of average power at the repetition rate of 77 MHz, corresponding to 462 kW (406 kW) of peak power and 41 nJ (38 nJ) of pulse energy. To the best of our knowledge, this represents the highest average and peak powers generated to date from quantum-dot saturable absorber-based mode-locked lasers.

574-647 nm wavelength tuning by second-harmonic generation from diode-pumped PPKTP waveguides.

We present a compact, all-room-temperature continuous-wave laser source in the visible spectral region between 574 and 647 nm by frequency doubling of a broadly tunable InAs/GaAs quantum-dot external-cavity diode laser in a periodically poled potassium titanyl phosphate crystal containing three waveguides with different cross-sectional areas (4×4, 3×5, and 2 µm×6 µm). The influence of a waveguide's design on tunability, output power, and mode distribution of second-harmonic generated light, as well as possibilities to increase the conversion efficiency via an optimization of a waveguide's cross-sectional area, was systematically investigated. A maximum output power of 12.04 mW with a conversion efficiency of 10.29% at 605.6 nm was demonstrated in the wider waveguide with the cross-sectional area of 4 µm×4 µm.

Investigating tissue respiration and skin microhaemocirculation under adaptive changes and the synchronization of blood flow and oxygen saturation rhythms.

Multi-functional laser non-invasive diagnostic systems allow the study of a number of microcirculatory parameters, including index of blood microcirculation (Im) (by laser Doppler flowmetry, LDF) and oxygen saturation (StO2) of skin tissue (by tissue reflectance oximetry, TRO). This research aimed to use such a system to investigate the synchronization of microvascular blood flow and oxygen saturation rhythms under normal and adaptive change conditions. Studies were conducted on eight healthy volunteers of 21-49 years. These volunteers were observed between one and six months, totalling 422 basic tests (3 min each). Measurements were performed on the palmar surface of the right middle finger and the lower forearm's medial surface. Rhythmic oscillations of LDF and TRO were studied using wavelet analysis. Combined tissue oxygen consumption data for all volunteers during 'adaptive changes' increased relative to normal conditions with and without arteriovenous anastomoses. Data analysis revealed resonance and synchronized rhythms in microvascular blood flow and oxygen saturation as an adaptive change in myogenic oscillation (vasomotion) resulting from exercise and possibly psychoemotional stress. Synchronization of myogenic rhythms during adaptive changes may lead to increased oxygen consumption as a result of increased microvascular blood flow velocity.

Generating a three-dimensional dark focus from a single conically refracted light beam.

We report here the generation of a three-dimensional (3D) dark focus from a single focused monochromatic Gaussian beam that undergoes conical refraction when it propagates along one of the optic axes of a biaxial crystal. We study the resulting ring intensity pattern behind the crystal as a function of the ratio between the ring radius and the beam waist and derive the particular parameter values for which a 3D dark focus with null intensity at the ring center is formed. We have performed experiments with a KGd(WO(4))(2) biaxial crystal, reporting the generation of a bottle beam in full agreement with our theoretical investigations.

Infrared laser pulse triggers increased singlet oxygen production in tumour cells.

Photodynamic therapy (PDT) is a technique developed to treat the ever-increasing global incidence of cancer. This technique utilises singlet oxygen ((1)O2) generation via a laser excited photosensitiser (PS) to kill cancer cells. However, prolonged sensitivity to intensive light (6-8 weeks for lung cancer), relatively low tissue penetration by activating light (630 nm up to 4 mm), and the cost of PS administration can limit progressive PDT applications. The development of quantum-dot laser diodes emitting in the highest absorption region (1268 nm) of triplet oxygen ((3)O2) presents the possibility of inducing apoptosis in tumour cells through direct (3)O2 → (1)O2 transition. Here we demonstrate that a single laser pulse triggers dose-dependent (1)O2 generation in both normal keratinocytes and tumour cells and show that tumour cells yield the highest (1)O2 far beyond the initial laser pulse exposure. Our modelling and experimental results support the development of direct infrared (IR) laser-induced tumour treatment as a promising approach in tumour PDT.

85.7 MHz repetition rate mode-locked semiconductor disk laser: fundamental and soliton bound states.

Mode-locked optically pumped semiconductor disk lasers (SDLs) are in strong demand for applications in bio-medical photonics, chemistry, space communications and non-linear optics. However, the wider spread of SDLs was constrained as they are operated in high repetition rates above 200 MHz due to short carrier lifetimes in the semiconductors. Here we demonstrate experimentally and theoretically that it is possible to overcome the limitation of fast carrier relaxation and show significant reduction of repetition rate down to 85.7 MHz by exploiting phase-amplitude coupling effect. In addition, a low repetition rate SDL serves as a test-bed for bound soliton state previously unknown for semiconductor devices. The breakthrough to sub-100 MHz repetition rate will open a whole new window of development opportunities.

Orange-to-red tunable picosecond pulses by frequency doubling in a diode-pumped PPKTP waveguide.

A compact picosecond all-room-temperature orange-to-red tunable laser source in the spectral region between 600 and 627 nm is demonstrated. The tunable radiation is obtained by second-harmonic generation in a periodically poled potassium titanyl phosphate (PPKTP) multimode waveguide using a tunable quantum-dot external-cavity mode-locked laser. The maximum second-harmonic output peak power of 3.91 mW at 613 nm is achieved for 85.94 mW of launched pump peak power at 1226 nm, resulting in conversion efficiency of 4.55%.

Second harmonic generation in a low-loss orientation-patterned GaAs waveguide.

The technology of low-loss orientation-patterned gallium arsenide (OP-GaAs) waveguided crystals was developed and realized by reduction of diffraction scattering on the waveguide pattern. The propagation losses in the OP-GaAs waveguide were estimated to be as low as 2.1 dB/cm, thus demonstrating the efficient second harmonic generation at 1621 nm under an external pumping.

Conical Refraction: new observations and a dual cone model.

We propose a paraxial dual-cone model of conical refraction involving the interference of two cones of light behind the exit face of the crystal. The supporting experiment is based on beam selecting elements breaking down the conically refracted beam into two separate hollow cones which are symmetrical with one another. The shape of these cones of light is a product of a 'competition' between the divergence caused by the conical refraction and the convergence due to the focusing by the lens. The developed mathematical description of the conical refraction demonstrates an excellent agreement with experiment.

High-power quantum-dot-based semiconductor disk laser.

We demonstrate multiwatt cw output power from an optically pumped quantum-dot semiconductor disk laser. Continuous-wave output power of 4.35 W with 22% slope efficiency was demonstrated at a center wavelength of 1,032 nm. This represents an increase in power of 15 times and an increase in slope efficiency of 10 times from the previously published results using Stranski-Krastanow grown quantum dots. An intracavity diamond heat spreader was used for thermal management. The maximum output power was limited by the available pump power, and no sign of thermal rollover was observed.

Diode-pumped passively mode-locked Er,Yb:YAl3(BO3)4 laser at 1.5-1.6 microm.

We report the first demonstration to our knowledge of passive mode locking in a diode-pumped Er(3+) and Yb(3+) codoped YAl(3)(BO(3))(4) laser operating in the 1.5-1.6 microm spectral region. Low-loss GaInNAs quantum-well semiconductor saturable absorber mirrors are used for the initiation and stabilization of the ultrashort-pulse generation. Pulses as short as 4.8 ps were generated at 1530 nm with an average output power up to 280 mW for 2 W of absorbed pump power produced by a high-brightness tapered 980 nm laser diode. Passive mode locking has also been demonstrated around 1555 nm with typical average powers of around 100 mW and pulse durations of 5.1 ps.

Efficient doubling of femtosecond pulses in aperiodically and periodically poled KTP crystals.

Efficient doubling of femtosecond pulses in periodically and aperiodically poled KTP crystals is demonstrated by employing the quasiphasematched frequency conversion technique. Conversion efficiencies as high as 60% were achieved using either aperiodically or periodically poled KTP nonlinear crystals in an extracavity, single-pass configuration using a diode-pumped femtosecond Yb:KYW laser as the pump source. The temporal characteristics of the frequency-doubled pulses as a function of focusing conditions in a "thick" nonlinear crystal regime have been investigated experimentally and pulses as short as 177 fs have been generated at around 520 nm under strong focusing conditions using a KTP crystal with aperiodic poling.

Quantum-dot-based saturable absorber for femtosecond mode-locked operation of a solid-state laser.

A quantum-dot-based saturable absorber has been demonstrated to initiate the generation of femtosecond pulses from a passively mode-locked solid-state laser. Control and tuning of the pulse duration from 58 ps to 158 fs was achieved. The 158 fs transform-limited pulses at 1280 nm are the shortest pulses that were produced from the Cr:forsterite laser passively mode locked by an InAs/InGaAs quantum-dot semiconductor saturable absorber mirror.