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A post-marketing surveillance study assessed the adverse events and possible risk of elevated homocysteine levels after the supplementation with creatine-guanidinoacetic acid mixture in apparently healthy adults. The participants were recruited through social media platforms and online discussion boards, with side effects and total plasma homocysteine (T-Hcy) levels evaluated regularly during a supplementation period of 6 months. Thirthy eight individuals (n = 38, 34.2% female) completed the evaluation period and were included in the final analyses. Serious side effects were absent. Two participants (5.3%) reported transitional nausea during the introductory weeks of the supplementation; no participants stopped the treatment. Baseline T-Hcy levels were 11.6 ± 3.1 µmol/L (95% confidence interval [CI], from 10.6 to 12.6). The intervention induced a mild reduction in T-Hcy levels across the monitoring period (p = 0.028), with T-Hcy levels after 1, 2, 3, and 6 months were 10.4 ± 3.0 µmol/L, 10.6 ± 2.9 µmol/L, 10.1 ± 2.7 µmol/L, and 9.3 ± 2.8 µmol/L, respectively. These findings suggest the overall tolerability of creatine-guanidinoacetic mixture in healthy adults, with homocysteine-increasing risk of no concern.
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OBJECTIVES: To assess the impact of medium-term supplementation with dihydrogen and pyrroloquinoline quinone (PQQ) on mitochondrial biomarkers, brain metabolism, and cognition in elderly individuals diagnosed with mild cognitive impairment. DESIGN: A parallel-group, randomized, placebo-controlled, double-blind experimental design, maintaining a 1:1 allocation ratio between the experimental group (receiving the dihydrogen-producing minerals and PQQ) and the control group (receiving the placebo) throughout the trial. SETTING AND PARTICIPANTS: Thirty-four elderly individuals with mild cognitive impairment (mean age 71.9 ± 3.8 years; 28 females) voluntarily provided written consent to participate in this trial. Participants were assigned in a double-blind parallel-group design to receive either a dihydrogen-PQQ mixture (Alpha Hope®, CalerieLife, Irvine, CA) or placebo twice daily for a 6-week intervention period. METHODS: The primary endpoint was the change in serum brain-derived neurotrophic factor (BDNF) from baseline to the 6-week follow-up; secondary outcomes included cognitive function indices, specific metabolites in brain tissue, brain oxygenation, and the prevalence and severity of side effects. Interaction effects (time vs. intervention) were evaluated using two-way ANOVA with repeated measures and Friedman's 2-way ANOVA by ranks, for normally distributed data with homogeneous variances and non-homogeneous variances, respectively. RESULTS: Dihydrogen-PQQ resulted in a significant elevation in serum BDNF levels at the six-week follow-up (P = 0.01); conversely, no changes in BDNF levels were observed in the placebo group throughout the study duration (P = 0.27). A non-significant trend in the impact of interventions on BDNF levels was observed (treatment vs. time interaction, P = 0.14), suggesting a tendency for dihydrogen-PQQ to upregulate BDNF levels compared to the placebo. A significant interaction effect was observed for the Alzheimer's Disease Assessment Scale-Cognitive subscale (ADAS-Cog) scores in the orientation domain (P = 0.03), indicating the superiority of dihydrogen-PQQ over placebo in enhancing this cognitive aspect. Cerebral oxygenation saturation exhibited a significant increase following the administration of the dihydrogen-PQQ mixture, from 48.4 ± 7.2% at baseline to 52.8 ± 6.6% at 6-week post-administration (P = 0.005). In addition, brain N-acetyl aspartate levels significantly increased at seven out of thirteen locations post-intervention in participants receiving the mixture (P ≤ 0.05). CONCLUSIONS: Despite the limited number of participants included in the study for interpreting clinical parameters, the dihydrogen-PQQ mixture blend shows promise as a potential dietary intervention for enhancing mental orientation and brain metabolism in individuals with age-related mild cognitive decline.
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Biomarcadores , Factor Neurotrófico Derivado del Encéfalo , Encéfalo , Cognición , Disfunción Cognitiva , Suplementos Dietéticos , Mitocondrias , Cofactor PQQ , Humanos , Femenino , Anciano , Masculino , Método Doble Ciego , Cofactor PQQ/farmacología , Cognición/efectos de los fármacos , Biomarcadores/sangre , Encéfalo/metabolismo , Encéfalo/efectos de los fármacos , Factor Neurotrófico Derivado del Encéfalo/metabolismo , Factor Neurotrófico Derivado del Encéfalo/sangre , Mitocondrias/metabolismo , Mitocondrias/efectos de los fármacosRESUMEN
The purpose of this study was to compare the effects of velocity-based strength training (VBT) and percentage-based strength training (PBT) on absolute strength, explosive strength, speed, and agility, as well as markers of muscle damage after 6 weeks of exercise programs. The study included 30 young female individuals, divided into three groups of 10 participants: VBT, PBT, and control group. The main findings indicated that the VBT group and PBT group showed significant improvement in 1RM squat exercise (Δ% 27.87 and Δ% 8.98, respectively) and 1RM bench press (Δ% 14.47 and Δ% 8.65, respectively), but a greater enhancement was observed in the VBT group. In addition, VBT induced substantial changes in SJ (Δ% 14.32) and CMJ height (Δ% 7.69), while PBT had an improvement only in the SJ test (Δ% 6.72). The improvement noted in the VBT group could be attributed to its ability to tailor training intensity according to the speed of movement execution. This approach allows athletes to perform each repetition as fast as possible, thus maintaining an optimal intensity for explosive strength development. The capacity of VBT to adapt training intensity based on the speed of movement execution may be the key factor contributing to these results. Therefore, coaches and athletes should consider implementing VBT as a valuable tool to optimize strength and power development. In conclusion, VBT induced greater improvement in the 1RM squat, 1RM bench press, SJ, and CMJ compared to the group that performed the traditional strength training modality. Therefore, VBT is considered a more effective training tool regarding the development of absolute and explosive strength in young women.
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Preliminary studies demonstrated beneficial effects of dietary creatine across different post-viral fatigue syndromes. Creatine is often co-administered with glucose to improve its potency yet whether glucose boost the efficacy of creatine in long COVID remains currently unknown. In this report, we investigate the effects of 8-wk creatine intake with and without glucose on patient-reported outcomes, exercise tolerance, and tissue creatine levels in patients with long COVID. Fifteen male and female long COVID adult patients (age 39.7±16.0 y; 9 women) with moderate fatigue and at least one of additional long COVID-related symptoms volunteered to participate in this randomized controlled parallel-group interventional trial. All patients were allocated in a double-blind parallel-group design (1 : 1 : 1) to receive creatine (8 g of creatine monohydrate per day), a mixture of creatine and glucose (8 g of creatine monohydrate and 3 g of glucose per day), or placebo (3 g of glucose per day) t.i.d. during an 8-wk intervention interval. Two-way ANOVA with repeated measures (treatment vs. time interaction) revealed significant differences in changes in total creatine levels between the groups, showing an interaction effect at two brain locations (right precentral white matter F=34.740, p=0.008; partial η2=0.72; left paracentral grey matter F=19.243, p=0.019; partial η2=0.88), with creatine and creatine-glucose outcompeted placebo to elevate creatine levels at these two locations. Several long COVID symptoms (including body aches, breathing problems, difficulties concentrating, headache, and general malaise) were significantly reduced in creatine-glucose group at 8-wk follow-up (p≤0.05); the effect sizes for reducing body aches, difficulties concentrating, and headache were 1.33, 0.80, and 1.12, respectively, suggesting a large effect of creatine-glucose mixture for these outcomes. Our preliminary findings suggest that supplying exogenous creatine with glucose could be recommended as an effective procedure in replenishing brain creatine pool and alleviating long COVID features in this prevalent condition.
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COVID-19 , Creatina , Suplementos Dietéticos , Glucosa , Humanos , Creatina/administración & dosificación , Masculino , Femenino , Método Doble Ciego , Adulto , Glucosa/administración & dosificación , Persona de Mediana Edad , COVID-19/complicaciones , SARS-CoV-2 , Fatiga/tratamiento farmacológico , Síndrome Post Agudo de COVID-19 , Encéfalo/efectos de los fármacos , Encéfalo/metabolismo , Resultado del TratamientoRESUMEN
BACKGROUND: Adolescent malnutrition is a significant public health challenge in low-income and middle-income countries (LMICs), with long-term consequences for health and development. Community-based interventions have the potential to address multiple forms of malnutrition and improve the health outcomes of adolescents. However, there is a limited understanding of the content, implementation and effectiveness of these interventions. This scoping review aims to synthesise evidence on community-based interventions targeting multiple forms of malnutrition among adolescents in LMICs and describe their effects on nutrition and health. METHODS AND ANALYSIS: A comprehensive search strategy will be implemented in multiple databases including MEDLINE (through PubMed), Embase, CENTRAL (through Cochrane Library) and grey literature, covering the period from 1 January 2000 to 14 July 2023. We will follow the Participants, Concept and Context model to design the search strategy. The inclusion criteria encompass randomised controlled trials and quasi-experimental studies focusing on adolescents aged 10-19 years. Various types of interventions, such as micronutrient supplementation, nutrition education, feeding interventions, physical activity and community environment interventions, will be considered. Two reviewers will perform data extraction independently, and, where relevant, risk of bias assessment will be conducted using standard Cochrane risk-of-bias tools. We will follow the PRISMA Extension for Scoping Reviews checklist while reporting results. ETHICS AND DISSEMINATION: The scope of this scoping review is restricted to publicly accessible databases that do not require prior ethical approval for access. The findings of this review will be shared through publications in peer-reviewed journals, and presentations at international and regional conferences and stakeholder meetings in LMICs. SCOPING REVIEW REGISTRATION: The final protocol was registered prospectively with the Open Science Framework on 19 July 2023 (https://osf.io/t2d78).
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Países en Desarrollo , Desnutrición , Humanos , Adolescente , Desnutrición/prevención & control , Desnutrición/epidemiología , Desnutrición/terapia , Proyectos de Investigación , Servicios de Salud Comunitaria/organización & administración , Revisiones Sistemáticas como AsuntoRESUMEN
Dietary creatine has been recently put forward as a possible intervention strategy to reduce post-COVID-19 fatigue syndrome yet no clinical study so far evaluated its efficacy and safety for this perplexing condition. In this parallel-group, randomized placebo-controlled double-blind trial, we analyzed the effects of 6-month creatine supplementation (4 g of creatine monohydrate per day) on various patient- and clinician-reported outcomes, and tissue creatine levels in 12 patients with post-COVID-19 fatigue syndrome. Creatine intake induced a significant increase in tissue creatine levels in vastus medialis muscle and right parietal white matter compared to the baseline values at both 3-month and 6-month follow-ups (p < .05). Two-way analysis of variance with repeated measures revealed a significant difference (treatment vs. time interaction) between interventions in tissue creatine levels (p < .05), with the creatine group was superior to placebo to augment creatine levels at vastus medialis muscle, left frontal white matter, and right parietal white matter. Creatine supplementation induced a significant reduction in general fatigue after 3 months of intake compared to baseline values (p = .04), and significantly improved scores for several post-COVID-19 fatigue syndrome-related symptoms (e.g., ageusia, breathing difficulties, body aches, headache, and difficulties concentrating) at 6-month follow-up (p < .05). Taking creatine for 6 months appears to improve tissue bioenergetics and attenuate clinical features of post-COVID-19 fatigue syndrome; additional studies are warranted to confirm our findings in various post-COVID-19 cohorts.
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Sobrepeso , Propionatos , Adulto , Humanos , Heces , Hidrógeno , Agua , Ácidos Grasos VolátilesRESUMEN
Identifying factors influencing wrestling performance is important for determining which capacities should be developed the most. This research aimed to investigate whether anthropometric indices, generic fitness, and specific fitness performance determine the competitive success of young wrestlers. This research included 49 Croatian Greco-Roman male wrestlers aged 17.75 ± 1.51 years. Variables included training and competing experience, anthropometric indices, generic fitness (countermovement jump and handgrip strength), and specific wrestling fitness test (SWFT). Wrestlers were separated into medallists and non-medallists (i.e., wrestlers who won a medal at the previous National Championship and wrestlers who did not win a medal, respectively). The t-test for independent samples was used to determine the differences between the two categories in all variables. Moreover, discriminant analysis was performed to identify differences in a multivariate manner. Medallists and non-medallists did not differ in anthropometric indices and wrestling experience. Medallists had better results in the countermovement jump (t = 2.55, p < 0.01), handgrip strength (t = 2.77, p < 0.01), and SWFT performance (t = 2.29, p < 0.05) than non-medallists. The discriminant analysis confirmed that performance categories differed in generic and specific fitness tests (Wilks' Lambda = 0.73, p < 0.05). It could be suggested that coaches should develop both the generic and specific fitness of their wrestlers to become more successful at competitions.
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Background: The methodology applied for rapid weight loss (RWL) among elite wrestlers is quite unexplored. Therefore, the aim of this study was to analyze the prevalence of sources of influence and methods used for RWL and to determine the differences between wrestling styles. Methods: A total of 229 wrestlers who competed at the World Championship held in Belgrade, Serbia, participated in this research. All respondents completed a questionnaire designed to evaluate RWL patterns in combat athletes. Participants were classified according to wrestling style: Greco-Roman, freestyle, and women wrestling. Results: Sixty-nine percent of wrestlers had previously lost weight to compete. Most respondents start losing weight approximately seven days before a competition. Athletes reported that they commonly reduced 3.84 ± 2.82 kg to reach the target weight. The wrestling coach represents the most influential person in terms of RWL strategies, while nutritionists and physicians have the least impact on the weight-cutting process. Regarding the methods applied, differences between all the three styles were found in the following variables: training in a heated room, restricting fluid ingestion, training in plastic suits, gradual dieting, increased exercise, diet pills, and sauna. The most frequently used techniques were increased exercise, gradual dieting, training in a heated room, and sauna for all competitors. Diet pills, diuretics, laxatives, and vomiting were the least implemented methods. Conclusions: The obtained results suggest that most wrestlers practice RWL despite the harmful health effects. The education of wrestling coaches is necessary in order to control and decrease the negative impact of RWL.
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Laxativos , Lucha , Diuréticos , Femenino , Humanos , Prevalencia , Pérdida de PesoRESUMEN
Introduction: The main purpose of this study was to investigate children's swimming competence in primary schools of districts in Vojvodina, Serbia. Methods: Included subjects were primary school students from first to eighth grade (N = 2,778; male = 1,454, female = 1,324; age = 10.73 ± 2.1 years). We used Swimming Competence Questionnaire to acquire and analyze their swimming experience, non-fatal aquatic events, and demographics. For the statistical analysis, logistic regression and hierarchical multiple regression were used to evaluate if the factors and SC and NFAE were associated. The analyses were carried out by using SPSS® software version 24.0 (SPSS, Inc., Chicago, Illinois, USA). Results: Families with more income and education generally have children with more swimming competence, experience, knowledge, and skills related to water safety. First step in analysis revealed that gender (ß = 0.05, p < 0.01), education level (ß = 0.06, p < 0.01) age (ß = 0.171, p < 0.01), and family income (ß = 0.04, p < 0.01) were significant swimming competence (SC) predictors (R2 = 0.04). Age (OR = 1.15, p < 0.01) was the only significant predictor in Step 1 predicting non-fatal aquatic events (NFAE). In Step 2, variables associated with SC were swimming location (ΔR2 = 0.06, p < 0.01), swimming experience (ΔR2 = 0.16, p < 0.01), swimming accessibility (ΔR2 = 0.05, p < 0.01), and learning experience (ΔR2 = 0.03, p < 0.01) (total R2 = 0.26 to 0.47, p < 0.01). Only a minority of participants reported that they could not swim further than 5 meters using general stroke (37.15%). Conclusion: National education trainers programs must be prioritized with the primary strategy of transferring knowledge to swimming and water safety. Families with lower income must be included without exceptions. This is perhaps a key factor in preventing NFAE, increasing SC, and increasing water safety.
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Ahogamiento , Natación , Niño , Ahogamiento/epidemiología , Ahogamiento/prevención & control , Escolaridad , Femenino , Humanos , Masculino , Encuestas y Cuestionarios , Natación/educación , AguaRESUMEN
Several factors that follow the development of society affect physical inactivity, which primarily includes the development of technology and digitalization and the increasing choice of unhealthy lifestyle habits. However, certain shifts in the fitness industry have been noted in the last decade. The development of wearable technologies and artificial intelligence is one of the leading fitness trends and undoubtedly represents the future of the fitness industry. On the other hand, the significant influence of social media and networks affects the development and attitudes of people related to physical activity. Therefore, this review paper evaluates the advantages and disadvantages of wearable technologies and artificial intelligence, the positive and negative effects of social networks, and points out the problems accompanying these new fitness trends. The development of fitness trends follows humanity's needs, and one of the biggest challenges is incorporating these novelties in a mission to improve physical activity levels worldwide.
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Inteligencia Artificial , Medios de Comunicación Sociales , Ejercicio Físico , Humanos , Conducta Sedentaria , Red SocialRESUMEN
BACKGROUND: Grappling is a wrestling style that combines different techniques such as freestyle wrestling, jiu-jitsu, judo, sambo, and others. As with other combat sports, it requires categorizing the athletes in weight classes, which leads to the use of certain methods to lose body weight in a short amount of time which poses a serious threat to athletes' health and wellbeing. Therefore, the objective of this study was to investigate the most widespread rapid weight loss (RWL) methods and sources of influence used by grappling athletes. METHODS: A total of 145 athletes took part in the study by voluntarily filling out a questionnaire regarding their weight loss techniques and methods. They were divided into two groups, male (27.7 ± 5.2 years, 1.76 ± 0.13 m, and 82.1 ± 20 kg) and female (27.33 ± 6.3 years, 1.65 ± 0.08 m, and 64.3 ± 10.4 kg), for further statistical analysis. After calculating descriptive statistics for all the variables, a t-test was conducted for gender differences in weight loss and weight regain, and a chi-square test measured the diversity in techniques and source of influence. RESULTS: Out of 145 participants, 120 athletes (85.2%) reported engaging in rapid weight loss prior to weigh-in. Coaches (52.4 and 59%) and teammates (42.6 and 22.1%) seemed to be the most influential on their rapid weight-loss strategies, whereas physicians (17.1 and 17.9%) and parents (23.2 and 23.1%) were the least influential. A statistical difference between men and women (p = 0.05) was found when teammates were a source of influence (42.6 and 21.1%, respectively). Regarding the methods used, both groups practiced gradual dieting (85.4 and 79.5%) as the most prevalent, followed by increased exercise (79 and 66.6%) and sauna (78.7 and 66.6%). Moreover, men trained in plastic suits significantly more often than women (67.1 vs. 41%, p = 0.01). CONCLUSION: Rapid weight loss is detrimental to athletes' health and wellbeing. Hence, it is crucial to find and implement methods that will control and ultimately limit its use in combat sports. Physicians and nutritionists need to be closely linked with the staff, collaborate and supervise the weight cutting.
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In combat sports, competitors are separated into weight divisions, to create equality between the athletes. Consequently, rapid weight loss (RWL) is a common practice in combat sports. Although the methods used to induce RWL are similar among athletes, currently, there are limited data concerning the RWL methodologies used by sambo athletes. Therefore, this study aimed at determining RWL procedures among female sambo athletes. Participants in the study were top-level athletes competing at the World Sambo Championship held in Novi Sad. A total sample of 47 female sambo athletes, of whom 24 were seniors (27.3 ± 4 year/age, 1.61 ± 0.09 m/height, 61.8 ± 8.87 kg/weight) and 23 juniors (18.7 ± 0.8 year/age, 1.66 ± 0.07 m/height, 63.7 ± 12.1 kg/weight), were examined in the study. To determine RWL methods, data were collected through a standardized questionnaire. As a result, 88.7% of the female sambo athletes declared that they intentionally cut their weight before the competition. The most commonly used methods were gradual dieting, followed by sauna, fluid restriction, and skipping meals. The most considerable influence on the RWL strategies of athletes came from coaches and personal trainers, while physicians and dietitians were far less influential. The results obtained from this representative sample highlight the most common practices concerning weight cutting prior to competition among females. Therefore, there is a need to inform and educate both athletes and coaches about the potentially harmful effects of RWL in combat sports.