Capturing the patient's voice: Kano Analysis of the Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) survey.

BACKGROUND: Traditional methods are not able to differentiate which feature customers regard as attractive, mandatory, performance, and which feature customers are indifferent about. These categories can only be differentiated based on a specific technique called Kano survey. Specific aim of this study was to categorize the Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) patient satisfaction survey questions into Kano categories. MATERIALS AND METHODS: Design of the study was survey research. It was conducted from 6/2019 to 8/2019 at OSF Saint Francis Medical Centre in Peoria, Illinois, USA. A 34 question Kano survey (17 positive and 17 negative questions) based on HCAHPS patient questionnaire was designed. Surveys were analyzed using Kano analysis template. Comparative analysis of Kano categories based on demographics was also performed. RESULTS: 39 current patients and 25 caregivers completed the survey. All of the 17 HCAHPS questions except "noise level at night" were classified as mandatory requirement with highest number for information on "indications of medicines." There was a minimum variability in the satisfaction coefficients but large variation in the dissatisfaction coefficients. More patients above 50 years consider "help going to bathroom" as mandatory (70.2% vs. 40.7%, P = 0.01). Sixty-four percent of caregivers considered "explain things (nurse)" as mandatory as opposed to 51.2% of patients (P = 0.03). CONCLUSION: Current U. S healthcare consumers have high expectations from healthcare delivery and consider most HCAHPS questions as mandatory requirements. Kano analysis needs to be done on a larger, more diverse hospital setting and potentially the HCAHPS survey needs to be modified to reflect prevailing healthcare customer requirements.

Double blind randomized controlled trial of deep brain stimulation for obsessive-compulsive disorder: Clinical trial design.

Obsessive-compulsive disorder (OCD), a leading cause of disability, affects ~1-2% of the population, and can be distressing and disabling. About 1/3 of individuals demonstrate poor responsiveness to conventional treatments. A small proportion of these individuals may be deep brain stimulation (DBS) candidates. Candidacy is assessed through a multidisciplinary process including assessment of illness severity, chronicity, and functional impact. Optimization failure, despite multiple treatments, is critical during screening. Few patients nationwide are eligible for OCD DBS and thus a multi-center approach was necessary to obtain adequate sample size. The study was conducted over a six-year period and was a NIH-funded, eight-center sham-controlled trial of DBS targeting the ventral capsule/ventral striatum (VC/VS) region. There were 269 individuals who initially contacted the sites, in order to achieve 27 participants enrolled. Study enrollment required extensive review for eligibility, which was overseen by an independent advisory board. Disabling OCD had to be persistent for ≥5 years despite exhaustive medication and behavioral treatment. The final cohort was derived from a detailed consent process that included consent monitoring. Mean illness duration was 27.2 years. OCD symptom subtypes and psychiatric comorbidities varied, but all had severe disability with impaired quality of life and functioning. Participants were randomized to receive sham or active DBS for three months. Following this period, all participants received active DBS. Treatment assignment was masked to participants and raters and assessments were blinded. The final sample was consistent in demographic characteristics and clinical features when compared to other contemporary published prospective studies of OCD DBS. We report the clinical trial design, methods, and general demographics of this OCD DBS sample.

Identification of Critical to Quality Elements for Intensive Care Rounds by Kano Analysis.

BACKGROUND: Pediatric cardiac intensive care unit rounds require high levels of efficiency in data transfer and decision making to achieve optimal performance. Traditional survey methods do not discriminate and prioritize effectively the elements of rounds essential to a provider. In this study, we describe our experience with a novel survey method (Kano analysis) to assess customers' (surgeons, intensivists, cardiologists, advanced practice nurses, and nurses) requirements from rounds. METHODS: A 26-point survey divided into 3 domains (presentation, decision, and process elements) was conducted among Pediatric Intensive Care Unit (PICU) providers. Based on the survey, attractive, must be, performance, indifferent, and reverse categories were identified using methods described in the literature. Average satisfaction and dissatisfaction coefficients and percentages of attractive and mandatory elements in subgroups were compared. Results from the quantitative analysis were charted on a categorization plane. RESULTS: The survey was returned by all providers with 96% valid responses. The highest satisfaction coefficient in the presentation domain was for "one line statement about the patient" (0.76), in the decision domain "rhythm/anti-arrhythmics" (0.54), and in the process domain "reformatting presentation script" (0.77). The highest dissatisfaction gradients were for "overnight events" (-0.91), "rhythm/anti-arrhythmics" (-0.71), and "asking families to join rounds" (-0.49). Among the 5 subgroups, surgeons required the largest percentage of items as mandatory or attractive and had the highest dissatisfaction coefficients in all 3 categories. CONCLUSION: Kano survey can provide rapid and precise actionable data to restructure a new process. Further research potentially also involving patients and families in the Kano survey may provide insight on patient-centered care models.

Gene ontology analysis of pairwise genetic associations in two genome-wide studies of sporadic ALS.

BACKGROUND: It is increasingly clear that common human diseases have a complex genetic architecture characterized by both additive and nonadditive genetic effects. The goal of the present study was to determine whether patterns of both additive and nonadditive genetic associations aggregate in specific functional groups as defined by the Gene Ontology (GO). RESULTS: We first estimated all pairwise additive and nonadditive genetic effects using the multifactor dimensionality reduction (MDR) method that makes few assumptions about the underlying genetic model. Statistical significance was evaluated using permutation testing in two genome-wide association studies of ALS. The detection data consisted of 276 subjects with ALS and 271 healthy controls while the replication data consisted of 221 subjects with ALS and 211 healthy controls. Both studies included genotypes from approximately 550,000 single-nucleotide polymorphisms (SNPs). Each SNP was mapped to a gene if it was within 500 kb of the start or end. Each SNP was assigned a p-value based on its strongest joint effect with the other SNPs. We then used the Exploratory Visual Analysis (EVA) method and software to assign a p-value to each gene based on the overabundance of significant SNPs at the α = 0.05 level in the gene. We also used EVA to assign p-values to each GO group based on the overabundance of significant genes at the α = 0.05 level. A GO category was determined to replicate if that category was significant at the α = 0.05 level in both studies. We found two GO categories that replicated in both studies. The first, 'Regulation of Cellular Component Organization and Biogenesis', a GO Biological Process, had p-values of 0.010 and 0.014 in the detection and replication studies, respectively. The second, 'Actin Cytoskeleton', a GO Cellular Component, had p-values of 0.040 and 0.046 in the detection and replication studies, respectively. CONCLUSIONS: Pathway analysis of pairwise genetic associations in two GWAS of sporadic ALS revealed a set of genes involved in cellular component organization and actin cytoskeleton, more specifically, that were not reported by prior GWAS. However, prior biological studies have implicated actin cytoskeleton in ALS and other motor neuron diseases. This study supports the idea that pathway-level analysis of GWAS data may discover important associations not revealed using conventional one-SNP-at-a-time approaches.

Ion channels and schizophrenia: a gene set-based analytic approach to GWAS data for biological hypothesis testing.

Schizophrenia is a complex genetic disorder. Gene set-based analytic (GSA) methods have been widely applied for exploratory analyses of large, high-throughput datasets, but less commonly employed for biological hypothesis testing. Our primary hypothesis is that variation in ion channel genes contribute to the genetic susceptibility to schizophrenia. We applied Exploratory Visual Analysis (EVA), one GSA application, to analyze European-American (EA) and African-American (AA) schizophrenia genome-wide association study datasets for statistical enrichment of ion channel gene sets, comparing GSA results derived under three SNP-to-gene mapping strategies: (1) GENIC; (2) 500-Kb; (3) 2.5-Mb and three complimentary SNP-to-gene statistical reduction methods: (1) minimum p value (pMIN); (2) a novel method, proportion of SNPs per Gene with p values below a pre-defined α-threshold (PROP); and (3) the truncated product method (TPM). In the EA analyses, ion channel gene set(s) were enriched under all mapping and statistical approaches. In the AA analysis, ion channel gene set(s) were significantly enriched under pMIN for all mapping strategies and under PROP for broader mapping strategies. Less extensive enrichment in the AA sample may reflect true ethnic differences in susceptibility, sampling or case ascertainment differences, or higher dimensionality relative to sample size of the AA data. More consistent findings under broader mapping strategies may reflect enhanced power due to increased SNP inclusion, enhanced capture of effects over extended haplotypes or significant contributions from regulatory regions. While extensive pMIN findings may reflect gene size bias, the extent and significance of PROP and TPM findings suggest that common variation at ion channel genes may capture some of the heritability of schizophrenia.

Psychiatric neurosurgery 2009: review and perspective.

In the treatment of psychiatric disorders, modern lesion procedures and nonablative deep brain stimulation (DBS) offer a degree of hope for patients who remain severely ill and impaired despite pharmacological and behavioral treatments. The available data support the therapeutic promise of these procedures, primarily for those suffering with obsessive-compulsive disorder (OCD) or major depressive disorder (MDD). However, the use of neurosurgical treatments for psychiatric disorders must be approached with both caution and a commitment to long-term care. The data also show that psychiatric neurosurgical procedures can be implemented most successfully by dedicated interdisciplinary teams in the context of a multimodal treatment plan. Treatment using these procedures is further complicated by issues involving the criteria for patient selection, the long-term management of patients receiving psychiatric neurosurgery, and the different patterns of potential clinical benefits and burdens presented by DBS and contemporary lesion procedures.

Pathways-based analyses of whole-genome association study data in bipolar disorder reveal genes mediating ion channel activity and synaptic neurotransmission.

Despite known heritability, the complex genetic architecture of bipolar disorder (likely including trait, locus and allelic heterogeneity, as well as genetic interactions) has confounded genetic discovery for many years. Even modern day whole genome association studies (WGAS) using over half a million common SNPs have implicated only a handful of genes at the genomewide level. Temporally coincident with this series of WGAS, a host of pathways-based analyses (PBAs) have emerged as novel computational approaches in the examination of large-scale datasets, but thus far rarely have been applied to WGAS data in psychiatric disorders. Here, we report a series of PBAs conducted using exploratory visual analysis, an analytic and visualization software tool for examining genomic data, to examine results from the National Institutes of Mental Health and Wellcome-Trust Case Control Consortium WGAS in bipolar disorder. Consistent with a host of prior linkage findings, some candidate gene association studies, and recent WGAS, our strongest findings suggest involvement of ion channel structural and regulatory genes, including voltage-gated ion channels and the broader ion channel group that comprises both voltage- and ligand-gated channels. Moreover, we found only modest overlap in the particular genes driving the significance of these gene sets across the analyses. This observation strongly suggests that variation in ion channel genes, as a class of genes, may contribute to the susceptibility of bipolar disorder and that heterogeneity may figure prominently in the genetic architecture of this susceptibility.

Sleep locus of control: report on a new scale.

The psychometric properties of a new 8-item measure, the Sleep Locus of Control Scale (SLOC), were investigated. A sample of 425 adult alumnae from the University of Manitoba and 57 community volunteers with chronic insomnia were surveyed. Results showed that the SLOC had acceptable reliability (i.e., internal consistency) and demonstrated convergent and discriminant validity through patterns of association with the Multidimensional Health Locus of Control Scale (Wallston, Wallston, & DeVellis, 1978). Principal factors extraction with varimax rotation identified two factors underlying the SLOC Scale. One factor captured an internal sleep locus of control orientation and the other reflected a chance sleep locus of control orientation. In the adult alumnae sample, having a more chance sleep locus of control was associated with greater perfectionism, depression, and anxiety. In adults with chronic insomnia, having a more internal sleep locus of control orientation was associated with increased sleep-related anxiety. One implication of the study is that too much emphasis on developing an internal sleep locus of control may be counterproductive (i.e., associated with increased sleep-related anxiety). Instead, achieving a balance between an internal and chance sleep locus of control orientation may be an important goal when treating individuals with chronic insomnia.