Cell death and survival due to cytotoxic exposure modelled as a two-state Ising system.

Cancer chemotherapy agents are assessed for their therapeutic utility primarily by their ability to cause apoptosis of cancer cells and their potency is given by an IC50 value. Chemotherapy uses both target-specific and systemic-action drugs and drug combinations to treat cancer. It is important to judiciously choose a drug type, its dosage and schedule for optimized drug selection and administration. Consequently, the precise mathematical formulation of cancer cells' response to chemotherapy may assist in the selection process. In this paper, we propose a mathematical description of the cancer cell response to chemotherapeutic agent exposure based on a time-tested physical model of two-state multiple-component systems near criticality. We describe the Ising model methodology and apply it to a diverse panel of cytotoxic drugs administered against numerous cancer cell lines in a dose-response manner. The analysed dataset was generated by the Netherlands Translational Research Center B.V. (Oncolines). This approach allows for an accurate and consistent analysis of cytotoxic agents' effects on cancer cell lines and reveals the presence or absence of the bystander effect through the interaction constant. By calculating the susceptibility function, we see the value of IC50 coinciding with the peak of this measure of the system's sensitivity to external perturbations.

On the classical vibrational coherence of carbonyl groups in the selectivity filter backbone of the KcsA ion channel.

It has been suggested that quantum coherence in the selectivity filter of ion channel may play a key role in fast conduction and selectivity of ions. However, it has not been clearly elucidated yet why classical coherence is not sufficient for this purpose. In this paper, we investigate the classical vibrational coherence between carbonyl groups oscillations in the selectivity filter of KcsA ion channels based on the data obtained from molecular dynamics simulations. Our results show that classical coherence plays no effective role in fast ionic conduction.

Vorticity affects the stability of neutron stars

The spin rate Omega of neutron stars at a given temperature T is constrained by the interplay between gravitational-radiation instabilities and viscous damping. Navier-Stokes theory has been used to calculate the viscous damping time scales and produce a stability curve for r modes in the (Omega,T) plane. In Navier-Stokes theory, viscosity is independent of vorticity, but kinetic theory predicts a coupling of vorticity to the shear viscosity. We calculate this coupling and show that it can in principle significantly modify the stability diagram at lower temperatures. As a result, colder stars can remain stable at higher spin rates.