Self-care intervention using mobile apps for sexual and reproductive health in the WHO Eastern Mediterranean Region.

Sexual and reproductive health (SRH) concerns physical, mental, and social well-being as related to sexual and reproductive systems. Self-care, which is the ability to promote health without the support of a health-care provider, can advance SRH, especially for fragile populations. Mobile health (mHealth) solutions can be used to raise awareness about SRH. We performed a structured literature review and analysis of mHealth-based approaches for delivering self-SRH services and interventions in the WHO Eastern Mediterranean Region (EMR). A fuzzy-based framework for assessing those mHealth apps was proposed. We identified 6 out of 737 papers, and 23 (5.7%) out of 400 mHealth apps retrieved from app-stores, describing mHealth use for self SRH with only 10 apps developed in EMR countries, namely Morocco, Pakistan, Egypt, Iran, and Jordan. Our fuzzy-based framework proposes guidelines regarding the implementation of self-care interventions to help project leaders promote their adoption in the SRH systems.

Molecular Modeling Targeting the ACE2 Receptor with Cannabis sativa's Active Ingredients for Antiviral Drug Discovery against SARS-CoV-2 Infections.

The emergence of a novel coronavirus that later on rendered a global pandemic, caused desperation within the communities and drove increased interest in exploring medicinal plant-based therapeutics to treat and prevent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus infections. Many medicinal plants have been reported to have antiviral, anti-inflammatory, and immunomodulatory effects that hinder, cure, or ease the symptoms of COVID-19 infection. This exploratory study seeks to dock the active components of Cannabis sativa, a natural plant with several pharmacological and biological properties, with the angiotensin-converting enzyme II (ACE2) receptor. A total of 3 C. sativa active components have been found to bind to the ACE2 protein active site and could inhibit spike binding, although they do not compete directly with the receptor-binding domain (RBD) of SARS-CoV-2. 6-Prenylapigenin, cannabivarin (CBN-C3), and Δ8-tetrahydrocannabinolic acid-A (Δ8-THCA) have a greater affinity (-8.3, -8.3, and -8.0 kcal/mol, respectively) and satisfactory interaction with ACE2 than its inhibitor MLN-4760 (-7.1 kcal/mol). These potential drugs with higher affinity for the ACE2 receptor and adequate absorption, distribution, metabolism, excretion, and toxicity (ADMET) values are candidates for treating or preventing SARS-CoV-2 infections. In vitro and in vivo investigations are needed to evaluate further the efficacy and toxicity of these hit compounds.

Moroccan Digital Health Response to the COVID-19 Crisis.

The COVID-19 pandemic and the draconian measures applied to limit its spread have accelerated the process of digitalizing many activities, including those within the health sector. In Morocco, a developing country in northern Africa, digital health has been deployed extensively, and in a remarkable way, to support the management of the current health crisis. Morocco is taking significant measures to become a key player in the process of achieving Sustainable Development Goals (SDG) goal 3. The government has comprehensively integrated digital technology throughout its coordinated containment and mitigation processes. These processes encompass testing and diagnostics; virus genomic surveillance; telecare of suspected and chronic patients; COVID-19 patient contact tracing and tracking; a laboratory information system for medical material dispatching, biological sample collection, and data processing nationwide; and smart vaccination management. Moreover, the pace of amending legislation for enabling efficient telemedicine practice has been achieved at a record-breaking. The successful implementation of all of these digital health strategies testify to the effectiveness of digitalization for managing the health aspects of the pandemic and for the future development of health systems in Morocco and in the African continent, where digital health and telemedicine is set to become the cornerstone of medical practice.