1.
Bioorg Med Chem Lett
; 13(4): 693-6, 2003 Feb 24.
Artículo
en Inglés
| MEDLINE
| ID: mdl-12639560
RESUMEN
Novel (E)-N(1)-(benzyl)cinnamamidines were prepared and evaluated as NR2B subtype NMDA receptor ligands. Excellent affinity was achieved by appropriate substitution of either phenyl ring. The 2-methoxybenzyl compound 1h had approximately 1,000-fold lower IC(50) in NR2B than NR2A-containing cells. Replacement of the styryl unit by 2-naphthyl was well tolerated.