Low-frequency exercise training improves cardiovascular fitness and strength during treatment for breast cancer: a single-arm intervention study.

Aerobic and resistance exercise during and after cancer treatment are important for health-related outcomes, however treatment-specific barriers may inhibit adherence. We explored the effect of lower-frequency exercise training on fitness, body composition, and metabolic markers (i.e. glucose and lipids) in a group of recently diagnosed breast cancer patients. Fifty-two females ≥ 18 years with stage I-IIIB breast cancer were instructed to attend 2 cardiovascular and strength training sessions/week over 12 weeks, but program length was expanded as needed to accommodate missed sessions. Pre- and post-intervention, we measured: (1) cardiovascular fitness, (2) isometric strength, (3) body composition (dual-energy X-ray absorptiometry), and (4) fasting glucose, insulin, c-peptide, and lipids. Pre-intervention, participants were 53 ± 10 years old (mean ± SD) and overweight (BMI: 27.5 ± 5.4 kg m-2, 40.1 ± 6.5% body fat). Forty participants completed the program over a median 20 weeks (range: 13-32 weeks, median frequency: 1.2 sessions/week), over which predicted VO2peak improved by 7% (2.2[0.1-4.4] mL/kg/min) (delta[95% CI]), and strength increased by 7-9% (right arm: 2.3[0.1-4.5] N m; right leg: 7.9[2.1-13.7] N m; left leg: 7.8[1.9-13.7] N m). Body composition and metabolic markers were unchanged. An exercise frequency of 1.2 sessions/week stimulated significant improvements in fitness, and may represent a practical target for patients during active treatment.

Bioelectrical Impedance Analysis Overestimates Fat-Free Mass in Breast Cancer Patients Undergoing Treatment.

BACKGROUND: Bioelectrical impedance analysis (BIA) is commonly used to assess fat-free mass (FFM) and fat mass (FM) in breast cancer patients. However, because of the prevalence of overweight, obesity and variable hydration status in these patients, assumptions for existing prediction equations developed in healthy adults may be violated, resulting in inaccurate body composition assessment. METHODS: We measured whole-body FFM using single-frequency BIA (50 kHz) and dual-energy x-ray absorptiometry (DXA) in 48 patients undergoing treatment for breast cancer. We applied raw BIA data to 18 previously published FFM prediction equations (FFMBIA ) and compared these estimates to DXA (FFMDXA ; reference method). RESULTS: On average, patients were 52 ± 10 (mean ± SD) years of age and overweight (body mass index: 27.5 ± 5.5 kg/m2 ; body fat by DXA: 40.1% ± 6.6%). Relative to DXA, BIA overestimated FFM by 4.1 ± 3.4 kg (FFMDXA : 42.0 ± 5.9 kg; FFMBIA : 46.1 ± 3.4 kg). Individual equation-generated predictions of FFMBIA ranged from 39.6 ± 6.7 to 52.2 ± 5.6 kg, with 16 equations overestimating and 2 equations underestimating FFMBIA compared with FFMDXA . Based on equivalence testing, no equation-generated estimates were equivalent to DXA. CONCLUSION: Compared with DXA, BIA overestimated FFM in breast cancer patients during treatment. Although several equations performed better than others, none produced values that aligned closely with DXA. Caution should be used when interpreting BIA measurements in this clinical population, and future studies should develop prediction equations specific to breast cancer patients.

Plasma amino acid profiles of breast cancer patients early in the trajectory of the disease differ from healthy comparison groups.

This study describes and compares fasting plasma amino acid profiles of breast cancer patients near the initiation of chemotherapy with those of healthy age- and body mass index-matched females (HM), as well as young healthy females (HY). Breast cancer patients had significantly greater glutamate and histidine concentrations and significantly lower threonine concentrations compared with HM and HY females independent of protein or caloric intake. These differences may be related to metabolic perturbations associated with the disease.

A comprehensive metabolic evaluation reveals impaired glucose metabolism and dyslipidemia in breast cancer patients early in the disease trajectory.

BACKGROUND & AIMS: Weight gain in breast cancer patients during treatment is prevalent; the metabolic implications of this weight gain are poorly understood. We aimed to characterize glucose metabolism in breast cancer patients near the initiation of chemotherapy. METHODS: Stage I-II breast cancer patients (n = 8) were evaluated near the initiation of chemotherapy and compared with a group of age- and body mass index-matched, as well as a group of young healthy, non-malignant females. Fasting blood samples (analyzed for lipids and cytokines) were taken and an oral glucose tolerance test was performed. Body composition, waist circumference, diet, cardiovascular fitness and muscle strength were evaluated. RESULTS: Breast cancer patients were abdominally obese (mean ± SD: 94.6 ± 14.0 cm), overweight (28.8 ± 6.0 kg/m(2)) and dyslipidemic (triacylglycerides: 1.84 ± 1.17 mM; high-density lipoprotein cholesterol: 1.08 ± 0.23 mM). Compared to non-malignant matched females, fasting glucose and insulin concentrations were similar but fasting c-peptide was greater in patients (2.6 ± 1.2 ng/mL vs. 1.9 ± 0.8 ng/mL, p = 0.005). Glucose was elevated to a greater extent in patients during the oral glucose tolerance test compared with all non-malignant females. During the glucose tolerance test, c-peptide, but not insulin, remained elevated in patients compared with all non-malignant females. No differences in body composition, serum cytokines, nutrition or exercise capacity between patients and matched, non-malignant females emerged. CONCLUSIONS: Breast cancer patients present with unhealthy metabolic features early in the disease trajectory. Future investigations need to examine the underlying mechanisms and the potential longitudinal changes following chemotherapy.

UW WELL-FIT: the impact of supervised exercise programs on physical capacity and quality of life in individuals receiving treatment for cancer.

PURPOSE: The purpose of this study is to report physical function and quality of life data collected from cancer patients who participated in a supervised exercise intervention at the UW WELL-FIT program over 5 years. METHODS: Five hundred seventy-five participants from 18 to 84 years of age (mean, 54 years) were assessed and enrolled in the 24-session program while currently receiving treatment for cancer. Twice weekly, they participated in aerobic exercise, resistance training and stretching exercises for 1 h each time. Pre- and post-assessments were performed to document changes in physical function, while the short form-36 (SF-36) survey assessed changes in quality of life. RESULTS: Three hundred eighty-six participants completed the program, while 171 withdrew at some point over the 24 sessions. Pre- and post-cardiovascular assessments were performed on 305 (78.4%) participants. There was a significant increase in the maximum work rate attained and significant decreases in heart rate response, systolic blood pressure and rate of perceived exertion at the submaximal level (p < 0.01). The summary component scales of SF-36 (physical and mental) were significantly improved as well as all eight subscales (p < 0.01). CONCLUSIONS: The data collected from this program indicate that a comprehensive physical activity program involving cardiovascular exercise, resistance training and flexibility can significantly improve physical function and various quality of life indices for individuals undergoing treatment for cancer.

The effect of fatigue on trunk muscle activation patterns and spine postures during simulated firefighting tasks.

The purpose of this study was to determine the effect of a fatiguing task (3 min intense stair climbing) on the adopted spinal postures and trunk muscular activation patterns during three highly physically demanding simulated firefighting tasks. Following the fatigue protocol, it was observed that individuals adopted significantly greater spinal flexion (16.3 degrees maximum prior to fatigue as compared to 20.1 degrees post fatigue) and displayed reduced abdominal muscle activation as compared to before the fatigue protocol (mean ranging from 16.6% maximum voluntary contraction (MVC) to 30.6% MVC prior to fatigue as compared to ranging from 14.6% MVC to 25.2% MVC post fatigue). The reduced abdominal activation may be due to a reduction in co-contraction during these tasks, which may compromise spinal stability. Reduced co-contraction combined with the increased spinal flexion may increase the risk of sustaining an injury to the low back.

Relationships between lumbar flexibility, sit-and-reach test, and a previous history of low back discomfort in industrial workers.

The sit-and-reach (S&R) test is often included in standard fitness tests (e.g., Canadian Physical Activity, Fitness and Lifestyle Appraisal [CPAFLA]), justified on the assumption that it is an indicator of low back health. Two issues were examined here: Is low back flexibility linked to having a history of low back disorders? And is the S&R test an indicator of low back flexibility? The relationship between S&R test scores, lumbar range of motion, and having a history of low back discomfort was examined in 72 asymptomatic (at test time) industrial workers (70 M, 2 F; mean age 35 ys; height 1.79 m; mass 84.7 kg). The S&R test, among many collected, was performed according to the CPAFLA guidelines. History of low back discomfort (LBD) was categorized based on whether or not time was lost from work. The S&R test was unable to distinguish between those with a history of LBD and those without. Specific lumbar sagittal range of motion could make this distinction. A moderate correlation (r = 0.42) surfaced between S&R and lumbar flexibility. This study suggests that the value of S&R as an indicator of previous back discomfort is questionable and there may be better indicators for inclusion in the CPAFLA.

Previous history of LBP with work loss is related to lingering deficits in biomechanical, physiological, personal, psychosocial and motor control characteristics.

A cross-sectional retrospective study was made of currently asymptomatic workers who perform physically demanding jobs. To further quantify the association between various biomechanical, physiological, personal psychosocial and motor control parameters that linger due to a history of low back disorders. Seventy-two workers were recruited from heavy industry, 26 of whom had a history of disabling low back disorders (LBDs) sufficient to miss work while the others did not. The strength of the study lies in the many detailed variables measured. Having a history of low back disorders was found to be associated with a larger waist girth, a greater potential for low back pain chronicity as predicted from psychosocial questionnaires, perturbed flexion to extension strength and endurance ratios, and widespread motor control deficits across a variety of tasks, some of which resulted in high back loads. In those workers who had missed work due to back disorders, the length of time since their last disabling episode was 261 weeks on average, suggesting that multiple deficits may remain for a period of time. Having a history of LBD is associated with changes in attitudes, in body composition, and in the way people move, load their backs and respond to a variety of motor and stability challenges.