1.
Angew Chem Int Ed Engl
; 59(52): 23505-23509, 2020 12 21.
Artículo
en Inglés
| MEDLINE
| ID: mdl-32914518
RESUMEN
An endohedrally functionalized self-assembled Fe4 L6 cage complex can catalyze oxa-Pictet-Spengler cyclizations of tryptophols and various aldehyde derivatives, showing strong rate accelerations and size-selectivity. Selective molecular recognition of substrates controls the reactivity, and the cage is capable of binding and activating multiple different species along the multistep reaction pathway. The combination of a functionalized active site, size-selective reactivity, and multistep activation, all from a single host molecule, illustrates the biomimetic nature of the catalysis.