Asunto(s)
Antibacterianos , Fluoroquinolonas , Gonorrea , Neisseria gonorrhoeae , Humanos , Antibacterianos/uso terapéutico , Antibacterianos/administración & dosificación , Gonorrea/tratamiento farmacológico , Gonorrea/microbiología , Fluoroquinolonas/uso terapéutico , Fluoroquinolonas/administración & dosificación , Neisseria gonorrhoeae/efectos de los fármacos , Neisseria gonorrhoeae/genética , Masculino , Femenino , Artritis Infecciosa/tratamiento farmacológico , Artritis Infecciosa/microbiología , Adulto , Administración Oral , Persona de Mediana Edad , Pruebas de Sensibilidad MicrobianaRESUMEN
OBJECTIVE: The prevalence of drug-resistant Neisseria gonorrhoeae (NG) infections is increasing. Studies report the prevalence of NG strains presenting A2059G/C2611T (rRNA23S) and S91F (parC) mutations conferring resistance to azithromycin and ciprofloxacin. METHODS: We conducted a prospective cohort study evaluating first void-urine urines, rectal, and oropharyngeal swabs collected from a cohort of patients in a tertiary hospital in Madrid between October 2022 and January 2023. Samples were screened by Allplex 7-STI Essential Assay (Seegene). Drug resistances were performed by Allplex NG-DR Assay (Seegene). RESULTS: A total of 1,415 patients were included, of which 112 had a positive sample for NG infection. One patient had a C2611T mutation (0.9%) and neither patient showed A2059G mutation. We found 67 (59.8%) S91F-positive patients. Forty-four patients (39.3%) not had any mutations. CONCLUSIONS: We report a low-prevalence of mutations A2059G/C2611T to macrolides and a high-prevalence to S91F in NG infections. Molecular methods for the detection of NG resistance could be useful in direct non-culturable samples.