RESUMEN
Chiari malformation type I (CM-1) is a disease in which part of the cerebellum and brainstem invades into the spinal canal beyond the foramen magnum. Patients with CM-1 can present with various symptoms; however, most cases of CM-1 are asymptomatic. Symptomatic cases are distributed bimodally in children and middle-aged adults, but occur very rarely in elderly individuals. We experienced a case of CM-1 onset after the age of 60 years that followed a favorable postoperative course. We report the potential mechanism of asymptomatic CM-1 in elderly patients along with a review of the literature.
Asunto(s)
Malformación de Arnold-Chiari , Adulto , Niño , Anciano , Persona de Mediana Edad , Humanos , Malformación de Arnold-Chiari/cirugía , Cerebelo , Tronco EncefálicoRESUMEN
ABSTRACT: Plaque-type blue nevus is a rare variant of blue nevi that was first described in 1954. This article presents clinical, macroscopic, histopathological, and genetic findings for a case of large plaque-type blue nevus expanding into the mammary gland tissue as well as the skin of the right breast. A 63-year-old woman presented with a congenital, large, blue-colored macule limited to the hypochondriac area of the right breast. A nodule 8 mm in diameter was also present in the mammary gland tissue. Magnetic resonance imaging was unable to detect diffuse melanin deposition in the mammary gland tissue, but pigmentation in the whole mammary parenchyma was observed in the cut surfaces of the mastectomy specimen. Histopathology revealed a sparse distribution of dendritic melanocytes in whole sections of the mammary fibrous tissue and partial sections of the dermis. The histopathological criteria for atypical cellular blue nevus were fulfilled for the mammary tumor. Nodal blue nevus was diagnosed in the sentinel lymph node. Sanger sequencing confirmed the GNAQ Q209P mutation, which was also identified in all 4 literature cases of plaque-type blue nevus, but rarely in conventional blue nevi and uveal melanoma. It should be noted that plaque-type blue nevus can expand into the mammary gland tissue, even if the pigmented lesion does not exist on the overlying breast skin. The mammary condition can be the origin of primary mammary melanocytic tumors. Mosaicism of the GNAQ Q209P mutation can be a characteristic genetic alteration to extensive blue nevi, including plaque-type blue nevus.
Asunto(s)
Neoplasias de la Mama/patología , Subunidades alfa de la Proteína de Unión al GTP Gq-G11/genética , Nevo Azul/patología , Neoplasias Cutáneas/patología , Neoplasias de la Mama/genética , Femenino , Humanos , Persona de Mediana Edad , Mutación , Nevo Azul/genética , Neoplasias Cutáneas/genéticaRESUMEN
ABSTRACT: This study aimed to identify the clinical and histopathological characteristics of secondary extramammary Paget disease (EMPD) with underlying anorectal adenocarcinoma so as to differentiate it from primary cutaneous EMPD. Seventeen and 8 cases of primary and secondary EMPD with anorectal adenocarcinoma, respectively, were retrieved from the pathology archive and the clinical and histopathological features reviewed. The tumor samples from 21 cases were totally resected specimens, whereas 3 and 1 of secondary and primary cases were punch biopsied, respectively. All 8 (100%) cases of secondary EMPD presented evenly distributed perianal lesions. By contrast, 4 of 17 (23.5%) primary EMPD cases had perianal skin lesions and displayed an uneven, asymmetrical distribution around the anus. Fibroepithelioma of Pinkus-like changes and subepidermal mucin deposits with no or few invasive tumor cells were observed in 6 (75%) and 3 (37.5%) of the 8 secondary EMPD cases, respectively, although 3 secondary case samples were small biopsy specimens. Both the histopathological changes were not observed in any of the 17 primary EMPD cases. Evenly circumferential perianal distribution, fibroepithelioma of Pinkus-like changes, and subepidermal mucin deposits without invasive tumor cells were characteristic to cases of secondary EMPD with anorectal adenocarcinoma. These clinicopathological features could be used to differentiate between secondary and primary EMPD.
Asunto(s)
Adenocarcinoma/patología , Neoplasias del Ano/patología , Neoplasias Fibroepiteliales/patología , Enfermedad de Paget Extramamaria/patología , Neoplasias del Recto/patología , Neoplasias Cutáneas/patología , Anciano , Anciano de 80 o más Años , Canal Anal/patología , Femenino , Humanos , Masculino , Persona de Mediana Edad , Mucinas/metabolismo , Enfermedad de Paget Extramamaria/metabolismo , Neoplasias Cutáneas/metabolismoAsunto(s)
Adenocarcinoma Papilar , Receptor Tipo 2 de Factor de Crecimiento de Fibroblastos , Neoplasias Cutáneas , Neoplasias de las Glándulas Sudoríparas , Adenocarcinoma Papilar/diagnóstico , Humanos , Inmunohistoquímica , Receptor Tipo 2 de Factor de Crecimiento de Fibroblastos/genética , Neoplasias Cutáneas/diagnóstico , Neoplasias de las Glándulas Sudoríparas/diagnósticoRESUMEN
We have measured the components of the throughfall under fir trees (Abies firma) in the field around Mt. Oyama, where the forest appears to be declining, for the period 1994-1998. Exposure experiments of a simulated acid fog to fir twigs were performed under field conditions. There was a similarity between the acid response in the field and that in the laboratory. In both studies, the severe leaching of calcium ions from the needle surface was caused by exposure to acid fog. We also applied acid fog to fir seedlings over 1 year and observed a decrease in the growth of the seedlings due to this application in the dormant season. These results suggest that the severe leaching of calcium ions due to acid fog may cause the deficiency of calcium and be responsible for the decline of the fir trees.