RESUMEN
An 11-year-old girl presented in autumn with an asymptomatic rash on her arms, face, and legs of a 3-week duration. What is your diagnosis?
Asunto(s)
Exantema , Enfermedades Cutáneas Genéticas , Niño , Humanos , Eritema/diagnóstico , Eritema/etiología , Enfermedades Cutáneas Genéticas/diagnósticoRESUMEN
Pyoderma gangrenosum (PG) is an inflammatory neutrophilic dermatosis with variable clinical features. The classic presentation is an ulceration with an erythematous to violaceous undermined border. Extracutaneous manifestations may occur. Associated systemic diseases include inflammatory bowel disease, inflammatory arthritides, and hematologic disorders. The pathophysiologic mechanism of disease is not completely known but likely related to the cumulative impact of inflammation, immune-mediated neutrophilic dysfunction, and genetic predisposition. Incidence is between 3 and 10 people per million but may be greater due to under recognition. In this article, we will discuss the diagnostic criteria, disease subtypes, systemic associations, and workup.
Asunto(s)
Enfermedades Inflamatorias del Intestino , Piodermia Gangrenosa , Humanos , Piodermia Gangrenosa/diagnóstico , Piodermia Gangrenosa/complicaciones , Inflamación/complicaciones , Enfermedades Inflamatorias del Intestino/complicaciones , Enfermedades Inflamatorias del Intestino/diagnóstico , Diagnóstico DiferencialRESUMEN
This case report describes erythematous patches on the face that involved the nasolabial folds, as well as numerous skin-colored homogenous waxy papules on the arms, neck, and trunk.
Asunto(s)
Mucinosis , Escleromixedema , Humanos , Escleromixedema/diagnóstico , Mucinosis/diagnósticoAsunto(s)
Sarcoidosis , Anomalías Cutáneas , Telangiectasia , Humanos , Sarcoidosis/diagnóstico , Telangiectasia/diagnósticoAsunto(s)
Dermatomiositis , Psoriasis , Anticuerpos Monoclonales Humanizados/uso terapéutico , Dermatomiositis/complicaciones , Dermatomiositis/tratamiento farmacológico , Método Doble Ciego , Humanos , Psoriasis/complicaciones , Psoriasis/tratamiento farmacológico , Índice de Severidad de la Enfermedad , Resultado del TratamientoRESUMEN
Numerous drugs have been linked to the induction or exacerbation of systemic cutaneous lupus erythematosus (SCLE). This report presents the third case of the biologic abatacept as an exacerbating medication for SCLE. A 73-year old woman with a remote history of subacute cutaneous lupus and rheumatoid arthritis, well controlled on hydroxychloroquine, presented with worsening annular erythematous, slightly scaly plaques on her forearms and hands. She had been started on abatacept a month prior. She was diagnosed with SCLE exacerbated by abatacept given the clinical findings, time course, and skin biopsy with interface dermatitis. Her skin eruption cleared completely several months later after discontinuing abatacept and switching to tociluzumab, while remaining on hydroxychloroquine. This case highlights the need to consider abatacept as a potential exacerbating medication for SCLE in any patient with a new photodistributed papulosquamous eruption.
Asunto(s)
Abatacept/efectos adversos , Artritis Reumatoide/tratamiento farmacológico , Inhibidores de Puntos de Control Inmunológico/efectos adversos , Lupus Eritematoso Cutáneo/inducido químicamente , Anciano , Anticuerpos Monoclonales Humanizados/uso terapéutico , Biopsia , Sustitución de Medicamentos , Femenino , Estudios de Seguimiento , Humanos , Lupus Eritematoso Cutáneo/diagnóstico , Piel/patología , Resultado del Tratamiento , Privación de TratamientoAsunto(s)
COVID-19 , Dermatología/educación , Internado y Residencia , Solicitud de Empleo , Estados UnidosAsunto(s)
Lupus Eritematoso Discoide/complicaciones , Trastornos por Fotosensibilidad/diagnóstico , Piel/patología , Luz Solar/efectos adversos , Atrofia/diagnóstico , Atrofia/etiología , Atrofia/patología , Biopsia , Cara , Femenino , Humanos , Lupus Eritematoso Discoide/inmunología , Lupus Eritematoso Discoide/patología , Trastornos por Fotosensibilidad/inmunología , Trastornos por Fotosensibilidad/patología , Piel/inmunología , Piel/efectos de la radiación , Adulto JovenRESUMEN
Unilateral hyperhidrosis of neurological origin has been associated with head trauma, cerebral palsy, spinal cord injury, peripheral neuropathy, lesions of the hypothalamus, and cerebral or brainstem strokes. In this report, we describe a 61-year-old man with isolated sweating on the left side of his entire body. A right-sided brainstem meningioma producing mass effect is suspected as the underlying etiology.