Death anxiety and older adults' vulnerability to fraud: the mediating role of materialism.

Death anxiety arousal, provoked by anticipating self-nonexistence, may be used as a fraud tactic by scammers on older adults; however, little is known about how it affects older adults' decision making when confronted with a scam and the mechanisms underlying these effects. This study used a questionnaire survey and experimental design to examine them. In Study 1, 307 older adults in China completed questionnaires. The results showed a positive link between death anxiety and vulnerability to fraud, partially mediated by materialism. In Study 2, 82 older adults in China were randomly assigned to the mortality salience group and control group to examine whether death anxiety arousal can increase older adults' vulnerability to fraud and the mediating role of materialism. The results indicated that death anxiety and materialism increase the risk of consumer products and services fraud; therefore, targeting these risk factors might protect older adults from fraud.

Construction and experimental validation of a necroptosis-related lncRNA signature as a prognostic model and immune-landscape predictor for lung adenocarcinoma.

Necroptosis is a new form of cell death. Since the discovery that long non-coding RNAs can affect the proliferation of lung adenocarcinoma, much has been learned about it, yet those of necroptosis-related long non-coding RNAs (NRlncRNAs) in lung adenocarcinoma (LUAD) remain enigmatic. This study aims to explore novel biomarkers and therapeutic targets for LUAD. The LUAD data was downloaded from The Cancer Genome Atlas, and necroptosis-related genes were retrieved from published literature. Co-expression analysis, univariate Cox analysis, least absolute shrinkage and selection operator regression analysis were used to identify necroptosis-related prognostic long non-coding RNAs. A comprehensive evaluation of tumor immunity for necrosis-related features was performed, and we identified a 9-NRlncRNA signature. Kaplan-Meier and Cox regression analyses confirmed that the signature was an independent predictor of LUAD outcome in the test and train sets (all P < 0.05). The areas of 1-, 2-, and 3-year overall survival under the time-dependent receiver operating characteristics (ROC) curve (AUC) were 0.754, 0.746, and 0.720, respectively. The GSEA results showed that 9 NRlncRNAs were associated with multiple malignancy-associated and immunoregulatory pathways. Based on this model, we found that the immune status and level of response to chemotherapy and targeted therapy were significantly different in the low-risk group compared with the high-risk group. qRT-PCR assay revealed that 9 NRlncRNAs were involved in the regulation of tumor cell proliferation and may affect the expression of programmed cell death 1 (PD1) and CD28 at human immune checkpoints. Our results indicated that the novel signature involving 9 NRlncRNAs (AL031600.2, LINC01281, AP001178.1, AL157823.2, LINC01290, MED4-AS1, AC026355.2, AL606489.1, FAM83A-AS1) can predict the prognosis of LUAD and are associated with the immune response. This will provide new insights into the pathogenesis and development of therapies for LUAD.

Understanding the mechanisms underlying the effects of loneliness on vulnerability to fraud among older adults.

The current study aimed to clarify the relationships among loneliness, susceptibility to persuasion, self-control, and vulnerability to fraud among older adults. Especially, we wanted to investigate whether susceptibility to persuasion mediates the association between loneliness and vulnerability to fraud, and whether self-control moderates the relationship in this process. A moderated mediation model was examined with 252 Chinese older adults (Mage = 67.94, SD = 6.27) who completed questionnaires regarding loneliness, susceptibility to persuasion, self-control, and vulnerability to fraud. The results revealed that loneliness significantly predicted older adults' vulnerability to fraud and susceptibility to persuasion partially mediated this relationship. Moreover, this mediating effect was only significant for older adults with low self-control. These findings enrich our understanding of how loneliness affects older adults' vulnerability to fraud and provide practical guidance for establishing protections against fraud targeting older adults.

A longitudinal study of depressive symptoms and delinquency among Chinese left-behind children.

This study sought to identify the developmental trajectories of depressive symptoms and delinquency in Chinese left-behind children (LBC) over a three-year period, a topic that is less often studied. Overall, 578 Chinese LBC (Mage= 10.63 years; boys = 53.1%) were tested three times on their depressive symptoms and delinquency from grades four through six. Unconditional latent growth modeling revealed no linear change in LBC's depressive symptoms, whereas there was a linear decrease over time in LBC's delinquency. Multiple-group models revealed that the pattern of change in LBC's delinquency differed across parental migration status and gender. Moreover, mother-only migration LBC showed higher initial depressive symptoms and initial delinquency levels than father-only migration LBC. The results provided a more accurate developmental picture by charting patterns of stability and change among Chinese LBC's depressive symptoms and delinquency in the context of parental migration.

Parent-child attachment and good behavior habits among Chinese children: Chain mediation effect of parental involvement and psychological Suzhi.

This study examines the mediation effect of parental involvement and psychological Suzhi between the relationship of parent-child attachment and good behavior habits in Chinese children. The participants comprised 563 children from four Chinese kindergartens (4.41±0.96) whose parents reported measures of parent-child attachment, parental involvement, psychological Suzhi, and good behavior habits in their children. The results indicated that (1) Parental attachment, parental involvement and psychological Suzhi were positively correlated with good behavior habits of young children; (2) Parental involvement and psychological Suzhi mediated the relationship between parent-child attachment and good behavior habits in children separately; (3) Parent-child attachment indirectly affected children's good behavior habits through the path of "parental involvement and psychological Suzhi."

A high-throughput drug screening strategy against coronaviruses.

The emergence and re-emergence of coronaviruses (CoV) continually cause circulating epidemics and pandemics worldwide, such as the on-going outbreak of the novel coronavirus SARS-CoV-2. The resultant disease, coronavirus disease 2019 (COVID-19), has rapidly developed into a worldwide pandemic, leading to severe health and economic burdens. Although the recently announced vaccines against COVID-19 has rekindled hope, there is still a major challenge to urgently meet the global need for rapid treatment of the pandemic. Given the urgency of the CoV outbreak, we propose a strategy to screen potential broad-spectrum drugs against CoV in a high-throughput manner, particularly against SARS-CoV-2. Since the essential functional domains of CoV are extensively homologous, the availability of two types of mild CoV, HCoV-OC43 and MHV, should provide a valuable tool for the rapid identification of promising drugs against CoV without the drawbacks of level three biological confinements. The luciferase reporter gene is introduced into HCoV-OC43 and MHV to indicate viral activity, and hence the antiviral efficiency of screened drugs can be quantified by luciferase activity. Compounds with antiviral activity against both HCoV-OC43 and MHV are further evaluated in SARS-CoV-2 after structural optimizations. This system allows large-scale compounds to be screened to search for broad-spectrum drugs against CoV in a high-throughput manner, providing potential alternatives for clinical management of SARS-CoV-2 or other CoV.

The Shackles of Fear: A Moderated Mediation Model of How Fear of Aging May Increase Older Adults' Vulnerability to Fraud.

Objectives: Older adults are disproportionately vulnerable to frauds of many kinds, and fear of aging has been conjectured to be a primary factor in older adults' vulnerability to fraud; however, no study has examined how and when fear of aging is associated with older adults' vulnerability to fraud.Methods: In this cross-sectional study, a sample of 251 Chinese older adults (M = 68.1, SD = 6.43) completed measures regarding fear of aging, intolerance of uncertainty, self-control, and vulnerability to fraud.Results: The results revealed that intolerance of uncertainty partially mediated the association between fear of aging and vulnerability to fraud. This indirect effect of fear of aging on vulnerability to fraud was only significant for older adults with lower levels of self-control.Conclusions: The association between fear of aging and older adults' vulnerability to fraud through intolerance of uncertainty varies as a function of self-control.Clinical implications: Clinicians may focus on reducing the fear of aging, decreasing intolerance of uncertainty, and enhancing self-control as promising pathways to develop effective interventions and outreach strategies aimed at protecting older adults from fraud.

Subjective Age and Memory Performance Among Older Chinese Adults : A Moderated Mediation Model.

This study aims to examine the mediating role of learning self-efficacy in the relationship between subjective age and memory performance as well as the moderating role of education in these indirect and direct relationships. A study was conducted with 200 older adults aged 60 to 81 years who completed measures of subjective age, learning self-efficacy, education, and memory performance. Analysis revealed that learning self-efficacy partially mediated the association between subjective age and memory performance. Further analysis found that the indirect associations between subjective age and memory through learning self-efficacy vary as a function of education. Implications and suggestions for future research are discussed.

'Feeling younger, remembering better': the effect of experimentally induced subjective age on memory performance among Chinese older adults.

Objectives: This study aimed to explore whether experimentally induced younger subjective age can lead to better memory performance among Chinese older adults.Method: A total of 203 participants aged 60-84 years were randomly assigned to three groups. In the positive and neutral feedback groups, participants were told that their memory performance was better than and equivalent to the same-aged peers after an initial memory task, respectively, in contrast to no feedback in the control group. Participants then completed a second memory measure.Results: The results revealed that participants in the positive feedback group felt younger and showed a significant increase in memory performance, whereas participants in the neutral feedback group felt older but also showed a significant increase in memory performance. For participants in the control group, no significant changes in memory performance were observed.Conclusion: It seems that experimentally induced younger subjective age can lead to better memory performance among older adults, providing a promising strategy to maintain memory functioning in old age.

The impact of effort-reward imbalance on loneliness of the elderly: the multiple mediation effect of social support and control belief in social domain.

Objective: The empirical studies of loneliness have experienced unprecedented growth in the past decades. As such, there is now a growing body of research showing that loneliness is negatively related to physical and mental health. More recently, one of the most widely tested models of effort-reward imbalance (ERI) posits that the imbalance between high effort and low reward elicits strong negative emotions and sustained stress responses. Despite these developments, the mechanism between ERI and loneliness of the elderly remains unclear. In the current study, we explored how ERI influences loneliness via social support and control belief in social domain. Method: We selected a convenience sample aged 53-84 years old (N = 231) to complete a series of standard psychological assessments. Results: Multiple mediation analysis showed that (1) the positive effect of ERI on loneliness was partially mediated by social support (95% IC = -.001 to .078) and control belief in social domain (95% IC = .028 to .154), and (2) the chain mediating effect of both mediators was also significant (95% IC = .037 to .112). Discussion: The study suggests that ERI can influence loneliness through decreasing social support and subsequently reducing control belief in social domain.

Why are older adults victims of fraud? Current knowledge and prospects regarding older adults' vulnerability to fraud.

Older adults are disproportionately targeted by various kinds of fraud, which result in irreversible economic losses and great psychological distress. Over the past years, researchers have conducted systematic research on the prevalence, under-reporting, and research methods of fraud victimization in older adults. Research paradigms regarding fraud victimization among older adults have mainly included cognitive, emotion regulation and motivation, and comprehensive paradigms. Factors shown to influence fraud victimization among older adults include cognitive decline, emotional regulation and motivational changes, their overly trusting nature, psychological vulnerability, social isolation, risk-taking, and a lack of knowledge and information regarding fraud prevention. Based on a review of the literature, future research can benefit from constructing a comprehensive fraud victimization theory, improving research methods, extending existing research, exploring physiological mechanisms of elderly fraud, and strengthening prevention and intervention efforts.

Commonalities and Differences in Psychological Adjustment to Chronic Illnesses Among Older Adults: a Comparative Study Based on the Stress and Coping Paradigm.

BACKGROUND: This study aimed to validate the role of the stress and coping paradigm in the context of psychological adjustment to chronic illnesses among older adults by using the structural equation modeling technique, as well as investigating the differences in structural weights between older adults with arthritis and older adults with hypertension. METHOD: A cross-sectional study was conducted with 325 older adults with chronic illnesses (149 hypertension, 176 arthritis), aged 60-88 years, who completed questions on perceived social support, psychological resources, threat appraisal, self-efficacy, coping strategy, depressive symptoms, and anxiety. RESULTS: The results revealed that older adults with arthritis experienced significantly higher anxiety (t = 2.91, p < 0.01) than those with hypertension, whereas no significant difference in their depressive symptoms was observed (t = 1.61, p > 0.05). Social support, psychological resources, threat appraisal, and self-efficacy had a significant direct relationship with psychological distress (ß = - 0.15, ß = - 0.38, ß = 0.19, ß = - 0.23, respectively). Multi-group analyses showed significant differences in structural weights between older adults with hypertension and those with arthritis (Δχ2 = 41.336, Δdf = 18, p < 0.01). CONCLUSION: The stress and coping paradigm appears to be applicable for adjustment to chronic illnesses by allowing direct paths from social support, psychological resources, threat appraisal, and self-efficacy to psychological distress. The differences in structural weights may offer an intervening angle for clinical practitioners to design targeted interventions for older adults with different types of chronic illnesses.

Credulity rather than general trust may increase vulnerability to fraud in older adults: a moderated mediation model.

The present study aimed to clarify whether it is credulity or general trust that specifically affects vulnerability to fraud, as well as investigating the mediating role of susceptibility to persuasion and the moderating role of greed in this relationship. 254 Chinese older adults completed measures of credulity, general trust, susceptibility to persuasion, greed, and vulnerability to fraud. The results showed that credulity, but not general trust, was positively correlated with vulnerability to fraud, after controlling for demographic covariates. Susceptibility to persuasion partially mediated the effect of credulity on vulnerability to fraud. In addition, this mediating effect of susceptibility to persuasion was only significant in older adults with higher levels of greed. Our findings suggest that credulity, rather than general trust, is a risk factor in vulnerability to fraud among older adults, and may inform the development of supportive interventions to reduce this population's risk of falling victim to fraud.

Subjective age and depressive symptoms among Chinese older adults: A moderated mediation model of perceived control and self-perceptions of aging.

Although subjective age has been shown to play an important role in older adults' experiences of depressive symptoms, the mediating and moderating mechanisms underlying this relationship have not been adequately examined. The present study aimed to investigate the mediating role perceived control plays between subjective age and depressive symptoms, as well as the moderating role self-perceptions of aging plays in this indirect relationship. To examine this, a cross-sectional study was conducted with 609 Chinese older adults, who completed measures of subjective age, perceived control, self-perceptions of aging, and depressive symptoms. The results indicated that: (1) possessing a younger subjective age is significantly associated with less depressive symptoms; (2) perceived control partially mediates the relationship between subjective age and depressive symptoms; and (3) the indirect effect of subjective age on depressive symptoms, through perceived control, is moderated by self-perceptions of aging, while the mediated path is stronger for older adults with less favorable self-perceptions of aging. The findings underscore the importance of identifying the mechanisms that moderate the mediated paths between subjective age and depressive symptoms.

Parent-Child Cohesion, Basic Psychological Needs Satisfaction, and Emotional Adaptation in Left-Behind Children in China: An Indirect Effects Model.

This study aimed to validate an indirect effects model of parent-child cohesion in emotional adaptation (i.e., loneliness and depression) via basic psychological needs satisfaction in Chinese left-behind children as well as the applicability of the model to both genders. A cross-sectional study was conducted and included 1,250 children aged between 9 and 12 years (635 left-behind children and 615 non-left-behind children) from rural primary schools. The results showed that: (1) relative to non-left-behind children, left-behind children exhibited significantly higher loneliness and depression scores and greater disadvantages involving father-child cohesion, mother-child cohesion, and psychological needs satisfaction. (2) Father- and mother-child cohesion were significantly negatively correlated with loneliness and depression and significantly positively correlated with psychological needs satisfaction in left-behind children. (3) Through structural equation modeling showed that psychological needs satisfaction partially mediated the relationship between parent-child cohesion and emotional outcomes in left-behind children. (4) Through multi-group analyses showed significant gender differences in structural weighting between parent-child cohesion and emotional adaptation, in that parent-child cohesion in left-behind boys was a stronger negative predictor of unfavorable emotional outcomes relative to that observed in left-behind girls, while psychological needs satisfaction in left-behind girls was a stronger negative predictor of unfavorable emotional outcomes relative to that observed in left-behind boys. The implications of these findings for interventions directed at Chinese left-behind children were discussed.

Well-being of elderly stroke survivors in Chinese communities: mediating effects of meaning in life.

OBJECTIVES: This study aims to examine the role of meaning in life as a mediator for the relationship of physical functioning, social support, and optimism with well-being among elderly Chinese stroke survivors. METHOD: A cross-sectional study was conducted on 214 community-dwelling older stroke survivors (128 men and 86 women), ranging from 60 to 88 years. The physical functioning, social support, optimism, meaning in life, and subjective well-being of the participants were measured. RESULTS: Structural equation modeling revealed that meaning in life fully mediates the relationship of physical functioning, social support, and optimism with subjective well-being. CONCLUSION: This study examines the role of meaning in life in stroke experience from an existential perspective. The modifiable features of meaning in life may offer an intervening angle for improving the well-being of elderly stroke survivors.

A meta-analysis of the prevalence of depressive symptoms in Chinese older adults.

This study aims to explore the prevalence and influence factors of depressive symptoms in Chinese older adults from 1987 to 2012. The study investigated 81 published papers on depressive symptoms in Chinese older adults using the 30-item Geriatric Depression Scale (GDS-30) or the Center for Epidemiologic Studies Depression Scale (CES-D) as a measuring tool through meta-analysis. A total of 88,417 Chinese older adults were included in this review. The pooled prevalence of depressive symptoms in Chinese older adults was 23.6% (95% CI: 20.3-27.2%). The pooled prevalence of depressive symptoms was greater in women. In addition, the prevalence of depressive symptoms in married older adults was lower than in single adults (i.e., divorced, unmarried or widowed). Depressive morbidity with GDS-30 was significantly higher than with CES-D. The prevalence of depressive symptoms in Chinese older adults presented a downward tendency with increasing educational level. Moreover, the prevalence of depressive symptoms gradually increased with the year of data collection. Significant differences were found in the measurement tools, gender, degree of education and marital status, but none in age.

Birth cohort changes in the depressive symptoms of Chinese older adults: a cross-temporal meta-analysis.

OBJECTIVE: With the dramatic changes in Chinese society and economy, the average depressive symptoms of Chinese older adults might have changed across their birth cohort. This study aims to examine the changes in the depressive symptoms of Chinese older adults by analyzing data from 1987 to 2010. METHODS: The study examines the changes in the Center for Epidemiologic Studies Depression Scale scores of older adults for the past 24 years (1987 to 2010) by using cross-temporal meta-analysis. A total of 35,299 older adults were included in the data. RESULTS: The results show the following. (i) Correlations between the mean scores and data collection year are significantly positive. The mean scores in the depressive symptoms of Chinese older adults show an increase of at least 0.53 standard deviations from 1987 to 2010. (ii) The means of the scores in the depressive symptoms of both male and female older adults exhibit a significant increase in the past 24 years, with the rising tendency of women being considerably higher than that of men. (iii) Depressive symptoms show a significant increase for different age groups in the past 24 years, whereas scores for depressive symptoms have no significant difference in terms of age group. CONCLUSIONS: Social changes play an important role in predicting the changes in the depressive symptoms of older adults.